| Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). | Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
Pavlović N, Kelam N, Racetin A, Filipović N, Pogorelić Z, Prusac IK, Vukojević K., Free PMC Article | 09/3/2024 |
| M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. | M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer.
Ran XM, Yang J, Wang ZY, Xiao LZ, Deng YP, Zhang KQ., Free PMC Article | 08/14/2024 |
| Hypermethylated ITGA8 Facilitate Bladder Cancer Cell Proliferation and Metastasis. | Hypermethylated ITGA8 Facilitate Bladder Cancer Cell Proliferation and Metastasis.
Ma X, Zhang L, Liu L, Ruan D, Wang C. | 01/26/2024 |
| LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma. | LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma.
Li X, Zhu G, Li Y, Huang H, Chen C, Wu D, Cao P, Shi R, Su L, Zhang R, Liu H, Chen J., Free PMC Article | 03/16/2023 |
| Bi-allelic pathogenic variants in ITGA8 cause slowly progressive renal disease of unknown etiology. | Bi-allelic pathogenic variants in ITGA8 cause slowly progressive renal disease of unknown etiology.
Gómez-Conde S, Dunand O, Hummel A, Morinière V, Gauthier M, Mesnard L, Heidet L. | 03/3/2023 |
| Glucocorticoids increase the risk of preterm premature rupture of membranes possibly by inducing ITGA8 gene expression in the amnion. | Glucocorticoids increase the risk of preterm premature rupture of membranes possibly by inducing ITGA8 gene expression in the amnion.
Okazaki Y, Taniguchi K, Miyamoto Y, Kinoshita S, Nakabayashi K, Kaneko K, Hamada H, Satoh T, Murashima A, Hata K. | 10/22/2022 |
| ITGA8 positive cells in the conventional outflow tissue exhibit Schlemm's canal endothelial cell properties. | ITGA8 positive cells in the conventional outflow tissue exhibit Schlemm's canal endothelial cell properties.
Wang Y, Wang W, Yang X, Chen W, Yang X, Pan X, Xu P, Zhu W, Han Y, Chen X. | 07/10/2021 |
| Integrin alpha8beta1 is the most fibroblast specific integrin and its contribution to fibrosis remains controversial. Recently, we demonstrated that alpha8beta1 plays a role in liver fibrosis in 4 different settings of mouse models; 3 with a neutralizing monoclonal antibody and one with Tam-inducible knockout mice. The mechanisms for the pro-fibrotic roles are through myofibroblast differentiation and TGF-beta activation. | Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis.
Nishimichi N, Tsujino K, Kanno K, Sentani K, Kobayashi T, Chayama K, Sheppard D, Yokosaki Y., Free PMC Article | 02/4/2021 |
| ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients | ITGA2B and ITGA8 are predictive of prognosis in clear cell renal cell carcinoma patients.
Lu X, Wan F, Zhang H, Shi G, Ye D. | 02/18/2017 |
| In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. | Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
Kohl S, Hwang DY, Dworschak GC, Hilger AC, Saisawat P, Vivante A, Stajic N, Bogdanovic R, Reutter HM, Kehinde EO, Tasic V, Hildebrandt F., Free PMC Article | 11/22/2014 |
| Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. | Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
Humbert C, Silbermann F, Morar B, Parisot M, Zarhrate M, Masson C, Tores F, Blanchet P, Perez MJ, Petrov Y, Khau Van Kien P, Roume J, Leroy B, Gribouval O, Kalaydjieva L, Heidet L, Salomon R, Antignac C, Benmerah A, Saunier S, Jeanpierre C., Free PMC Article | 04/5/2014 |
| the ITGA8 gene might have gender-specific roles in the development of schizophrenia. | A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta-Apha W, Yoshida M, Tamiya G, Sasada T, Eguchi N, Okazaki K, Shirakawa O, Someya T, Hishimoto A. | 03/30/2013 |
| Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. | Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.
Kitchen CM, Cowan SL, Long X, Miano JM., Free PMC Article | 02/23/2013 |
| The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. | [Expression and significance of integrins subunits in laryngeal squamous cell carcinoma].
Ni R, Shen X, Wu H, Zhu W, Ni J, Huang Z, Song Y, Gao X. | 08/27/2011 |
| alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. | Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.
Benoit YD, Larrivée JF, Groulx JF, Stankova J, Vachon PH, Beaulieu JF. | 09/20/2010 |
| In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. | Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.
Benoit YD, Lussier C, Ducharme PA, Sivret S, Schnapp LM, Basora N, Beaulieu JF., Free PMC Article | 01/21/2010 |
| These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. | Molecular basis of the recognition of nephronectin by integrin alpha8beta1.
Sato Y, Uemura T, Morimitsu K, Sato-Nishiuchi R, Manabe R, Takagi J, Yamada M, Sekiguchi K., Free PMC Article | 01/21/2010 |
| A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. | A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease.
Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A, Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease.
Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A, Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 04/3/2008 |
| expressed in developing kidney | Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.
Valerius MT, Patterson LT, Feng Y, Potter SS., Free PMC Article | 01/21/2010 |
| genomic analysis of the human integrin subunit alpha8 gene | Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8).
Ekwa-Ekoka C, Diaz GA, Carlson C, Hasegawa T, Samudrala R, Lim KC, Yabu JM, Levy B, Schnapp LM. | 01/21/2010 |
| Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. | Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.
Bieritz B, Spessotto P, Colombatti A, Jahn A, Prols F, Hartner A. | 01/21/2010 |
| Mammary carcinoma cells do express alpha8 integrin. | Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.
Scherberich A, Tucker RP, Degen M, Brown-Luedi M, Andres AC, Chiquet-Ehrismann R. | 01/21/2010 |