| Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia. | Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia.
Andrews JL, Zalesky A, Nair S, Sullivan RP, Green MJ, Pantelis C, Newell KA, Fernandez F., Free PMC Article | 11/29/2023 |
| Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration. | Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration.
Kalafatakis I, Papagianni F, Theodorakis K, Karagogeos D., Free PMC Article | 03/27/2023 |
| LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-kappaB and JAK2/STAT3. | LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3.
Zhu J, Zhu Z, Ren Y, Dong Y, Li Y, Yang X., Free PMC Article | 11/6/2021 |
| LINGO1 is a regulator of BK channels. | LINGO1 is a regulatory subunit of large conductance, Ca(2+)-activated potassium channels.
Dudem S, Large RJ, Kulkarni S, McClafferty H, Tikhonova IG, Sergeant GP, Thornbury KD, Shipston MJ, Perrino BA, Hollywood MA., Free PMC Article | 06/6/2020 |
| LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators. | LINGO1, C7orf31 and VEGFA are prognostic genes of primary glioblastoma: analysis of gene expression microarray.
Liu S, Xu Y, Zhang S. | 07/6/2019 |
| We identified homozygous missense variants in LINGO1, p.(Arg290His) in family F162 and p.(Tyr288Cys) in family PKMR65. Both variants were predicted to be pathogenic, and segregated with the phenotype in the respective families. Molecular modeling of LINGO1 suggests that both variants interfere with the glycosylation of the protein. | Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay.
Ansar M, Riazuddin S, Sarwar MT, Makrythanasis P, Paracha SA, Iqbal Z, Khan J, Assir MZ, Hussain M, Razzaq A, Polla DL, Taj AS, Holmgren A, Batool N, Misceo D, Iwaszkiewicz J, de Brouwer APM, Guipponi M, Hanquinet S, Zoete V, Santoni FA, Frengen E, Ahmed J, Riazuddin S, van Bokhoven H, Antonarakis SE. | 12/22/2018 |
| LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Chinese population. | Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson's disease and multiple system atrophy in a Chinese population.
Chen Y, Cao B, Yang J, Wei Q, Ou RW, Zhao B, Song W, Guo X, Shang H. | 09/10/2016 |
| LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells. | Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target.
Town J, Pais H, Harrison S, Stead LF, Bataille C, Bunjobpol W, Zhang J, Rabbitts TH., Free PMC Article | 08/20/2016 |
| Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR). | LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
Meabon JS, De Laat R, Ieguchi K, Wiley JC, Hudson MP, Bothwell M., Free PMC Article | 06/27/2015 |
| The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients. | Increased LINGO1 in the cerebellum of essential tremor patients.
Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH, Rajput A, Calon F. | 06/27/2015 |
| Lingo-1 signaling is altered in the schizophrenia brain. | Novel implications of Lingo-1 and its signaling partners in schizophrenia.
Fernandez-Enright F, Andrews JL, Newell KA, Pantelis C, Huang XF., Free PMC Article | 03/7/2015 |
| LINGO-1 can directly bind to ErbB2, block ErbB2 translocation into lipid rafts, and inhibit its phosphorylation. | LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts.
Lee X, Shao Z, Sheng G, Pepinsky B, Mi S. | 01/24/2015 |
| This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor. | Update on genetics of essential tremor.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Lorenzo-Betancor O, Pastor P, Agúndez JA. | 06/7/2014 |
| LINGO1 variants are associated with essential tremor in Chinese Han female patients. | Genetic analysis of the leucine-rich repeat and lg domain containing Nogo receptor-interacting protein 1 gene in essential tremor.
Liang H, Song Z, Deng X, Xu H, Zhu A, Zheng W, Zhao Y, Deng H. | 05/31/2014 |
| This study demonistrated that theLINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis. | LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis.
García-Martín E, Lorenzo-Betancor O, Martínez C, Pastor P, Benito-León J, Millán-Pascual J, Calleja P, Díaz-Sánchez M, Pisa D, Turpín-Fenoll L, Alonso-Navarro H, Ayuso-Peralta L, Torrecillas D, Lorenzo E, Plaza-Nieto JF, Agúndez JA, Jiménez-Jiménez FJ., Free PMC Article | 08/10/2013 |
| LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity. | LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
Zhang Z, Xu X, Xiang Z, Yu Z, Feng J, He C., Free PMC Article | 06/29/2013 |
| Results of a meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and risk of essential tremor (ET) and familial ET, while rs9652490 polymorphism is only associated with the risk for familial ET. | LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808.
Jiménez-Jiménez FJ, García-Martín E, Lorenzo-Betancor O, Pastor P, Alonso-Navarro H, Agúndez JA. | 02/16/2013 |
| the N-terminal region containing the leucine-rich repeats along with the transmembrane and cytoplasmic domains of LINGO-1 are not required for self-interaction or interaction with amyloid precursor protein | The leucine-rich repeats of LINGO-1 are not required for self-interaction or interaction with the amyloid precursor protein.
Stein T, Walmsley AR. | 01/26/2013 |
| the present meta-analysis does not support the notion that LINGO1 rs9652490 SNP is a major genetic risk factor for parkinson disease.[meta-analysis] | Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson's disease: twelve studies and a meta-analysis.
Wu Y, Wang X, Xu W, Liu W, Fang F, Ding J, Song Y, Chen S. | 11/17/2012 |
| This study showed that LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease. | LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease: results of a meta-analysis.
Agúndez JA, Lorenzo-Betancor O, Pastor P, García-Martín E, Luengo A, Alonso-Navarro H, Jiménez-Jiménez FJ. | 10/13/2012 |
| LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions | LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
Jepson S, Vought B, Gross CH, Gan L, Austen D, Frantz JD, Zwahlen J, Lowe D, Markland W, Krauss R., Free PMC Article | 09/22/2012 |
| There were no significant differences in frequencies for all alleles between the essential tremor (ET) group and controls; however, an association of genotype A/G of the SNP rs9652490 with the familial ET phenotype was found. | Screening of 10 SNPs of LINGO1 gene in patients with essential tremor in the Latvian population.
Radovica I, Inashkina I, Smeltere L, Vitols E, Jankevics E. | 09/15/2012 |
| Single nucleotide polymorphism(SNP)s of LINGO1 play a role in the development of Parkinson's disease in the Italian population. | Association study between the LINGO1 gene and Parkinson's disease in the Italian population.
Annesi F, De Marco EV, Rocca FE, Nicoletti A, Pugliese P, Nicoletti G, Arabia G, Tarantino P, De Mari M, Lamberti P, Gallerini S, Marconi R, Epifanio A, Morgante L, Cozzolino A, Barone P, Torchia G, Zappia M, Annesi G, Quattrone A. | 06/23/2012 |
| LINGO1 variants are not a major risk factor for developing familial essential tremor in this population, which suggests the existence of other genetic risk factors responsible for familial essential tremor in this movement disorder clinic population. | Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
Lorenzo-Betancor O, García-Martín E, Cervantes S, Agúndez JA, Jiménez-Jiménez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P. | 05/19/2012 |
| while there were no significant differences in the Lingo1 minor allele frequency and genotype frequency between Chinese essential tremor and controls, pooled analysis showed a higher proportion of GG genotype in tremor patients | Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians.
Wu YW, Rong TY, Li HH, Xiao Q, Fei QZ, Tan EK, Ding JQ, Chen SD. | 12/31/2011 |