| FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe. | FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe.
Jennings L, Walters HA, McCraw TJ, Turner JL, Mason JM., Free PMC Article | 01/3/2024 |
| Molecular insight into the PCNA-binding mode of FBH1. | Molecular insight into the PCNA-binding mode of FBH1.
Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG., Free PMC Article | 05/12/2023 |
| Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1-dependent regulation of Rad51. Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER. | PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.
Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND., Free PMC Article | 03/24/2018 |
| study does not provide evidence for the contribution of rare non-synonymous FBXO18 variations to the genetic etiol - ogy of schizophrenia in the Japanese population. | Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.
Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T. | 02/24/2018 |
| FBH1 acts as a negative regulator of RAD51 function in human cells | FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID. | 02/13/2016 |
| FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination. | FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID., Free PMC Article | 02/8/2014 |
| FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation. | FBH1 protects melanocytes from transformation and is deregulated in melanomas.
Jeong YT, Cermak L, Guijarro MV, Hernando E, Pagano M., Free PMC Article | 10/26/2013 |
| The study reports a mechanism that controls the degradation of FBH1 after DNA damage. | The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.
Bacquin A, Pouvelle C, Siaud N, Perderiset M, Salomé-Desnoulez S, Tellier-Lebegue C, Lopez B, Charbonnier JB, Kannouche PL., Free PMC Article | 09/21/2013 |
| FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks. | FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS. | 06/22/2013 |
| Ubiquitylation affects FBH1 interaction with the RAD51 nucleoprotein filament, but not its translocase and helicase activities. | Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.
Masuda-Ozawa T, Hoang T, Seo YS, Chen LF, Spies M., Free PMC Article | 06/15/2013 |
| FBH1 helicase activity is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress. | FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.
Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung P, Schildkraut CL, Pagano M., Free PMC Article | 03/30/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| Data show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box. | Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
Fugger K, Mistrik M, Danielsen JR, Dinant C, Falck J, Bartek J, Lukas J, Mailand N., Free PMC Article | 01/21/2010 |
| These findings suggest that the hFBH1 helicase is a functional human orthologue of budding yeast Srs2 that also possesses self-regulation properties necessary to execute its recombination functions. | The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.
Chiolo I, Saponaro M, Baryshnikova A, Kim JH, Seo YS, Liberi G., Free PMC Article | 01/21/2010 |
| hFBH1 exhibited DNA-dependent ATPase and DNA unwinding activities that displace duplex DNA in the 3' to 5' direction. | The novel human DNA helicase hFBH1 is an F-box protein.
Kim J, Kim JH, Lee SH, Kim DH, Kang HY, Bae SH, Pan ZQ, Seo YS. | 01/21/2010 |