| RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks. | RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.
Moore CE, Yalcindag SE, Czeladko H, Ravindranathan R, Wijesekara Hanthi Y, Levy JC, Sannino V, Schindler D, Ciccia A, Costanzo V, Elia AEH., Free PMC Article | 04/12/2023 |
| Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease. | Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.
Joseph SA, Taglialatela A, Leuzzi G, Huang JW, Cuella-Martin R, Ciccia A., Free PMC Article | 04/3/2021 |
| ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. | ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
Adeyemo AA, Zaghloul NA, Chen G, Doumatey AP, Leitch CC, Hostelley TL, Nesmith JE, Zhou J, Bentley AR, Shriner D, Fasanmade O, Okafor G, Eghan B Jr, Agyenim-Boateng K, Chandrasekharappa S, Adeleye J, Balogun W, Owusu S, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C, South Africa Zulu Type 2 Diabetes Case-Control Study, Collins F, Dunston G, Rotimi CN., Free PMC Article | 12/14/2019 |
| Nuclear RNR-alpha antagonizes cell proliferation by directly inhibiting ZRANB3 | Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3.
Fu Y, Long MJC, Wisitpitthaya S, Inayat H, Pierpont TM, Elsaid IM, Bloom JC, Ortega J, Weiss RS, Aye Y., Free PMC Article | 05/11/2019 |
| PCNA and ATP-dependency serve as a multi-layered regulatory mechanism that modulates ZRANB3 activity at replication forks. | Structural insights into the function of ZRANB3 in replication stress response.
Sebesta M, Cooper CDO, Ariza A, Carnie CJ, Ahel D., Free PMC Article | 12/22/2018 |
| A large number of SNF2 family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review] | Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.
Poole LA, Cortez D., Free PMC Article | 12/16/2017 |
| depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability | Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A., Free PMC Article | 10/28/2017 |
| Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance. | Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.
Vujanovic M, Krietsch J, Raso MC, Terraneo N, Zellweger R, Schmid JA, Taglialatela A, Huang JW, Holland CL, Zwicky K, Herrador R, Jacobs H, Cortez D, Ciccia A, Penengo L, Lopes M., Free PMC Article | 09/30/2017 |
| Here is described a substrate recognition domain within ZRANB3 that is needed for it to recognize forked DNA structures, hydrolyze ATP, catalyze fork remodeling, and act as a structure-specific endonuclease. | Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3).
Badu-Nkansah A, Mason AC, Eichman BF, Cortez D., Free PMC Article | 09/3/2016 |
| AH2 is recruited to stalled replication forks and that cells depleted of AH2 are hypersensitive to replication stresses. | The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.
Yuan J, Ghosal G, Chen J., Free PMC Article | 10/27/2012 |
| ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest. | Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ., Free PMC Article | 10/27/2012 |
| a role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability. | ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.
Weston R, Peeters H, Ahel D., Free PMC Article | 09/29/2012 |
| structural and functional differences between AH2 and HARP suggest that different annealing helicases have distinct functions in the cell. | Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif.
Yusufzai T, Kadonaga JT., Free PMC Article | 02/3/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |