| HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum. | HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum.
Golloshi K, Mitchell W, Kumar D, Malik S, Parikh S, Aljudi AA, Castellino SM, Chandrakasan S. | 06/28/2024 |
| Long non-coding RNA FLVCR1-AS1 functions as a ceRNA to aggravate cervical cancer cell growth by the miR-381-3p/MAGT1 axis. | Long non-coding RNA FLVCR1-AS1 functions as a ceRNA to aggravate cervical cancer cell growth by the miR-381-3p/MAGT1 axis.
Zhang J, Yang X, Ni H. | 11/12/2022 |
| Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer. | Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer.
Li L, Zhang X, Li Y, Xiao B, Pei S, Jiang H, Zhang X., Free PMC Article | 07/23/2022 |
| Identification of a novel MAGT1 mutation supports a diagnosis of XMEN disease. | Identification of a novel MAGT1 mutation supports a diagnosis of XMEN disease.
Watson CM, Nadat F, Ahmed S, Crinnion LA, O'Riordan S, Carter C, Savic S., Free PMC Article | 05/7/2022 |
| MAGT1 is required for HeLa cell proliferation through regulating p21 expression, S-phase progress, and ERK/p38 MAPK MYC axis. | MAGT1 is required for HeLa cell proliferation through regulating p21 expression, S-phase progress, and ERK/p38 MAPK MYC axis.
Bi C, Zhang X, Chen Y, Dong Y, Shi Y, Lei Y, Lv D, Cao X, Li W, Shi H., Free PMC Article | 04/23/2022 |
| CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes. | CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes.
Brault J, Liu T, Bello E, Liu S, Sweeney CL, Meis RJ, Koontz S, Corsino C, Choi U, Vayssiere G, Bosticardo M, Dowdell K, Lazzarotto CR, Clark AB, Notarangelo LD, Ravell JC, Lenardo MJ, Kleinstiver BP, Tsai SQ, Wu X, Dahl GA, Malech HL, De Ravin SS., Free PMC Article | 01/15/2022 |
| miR-199a-5p targeted regulation of MAGT1 expression in the functional depletion of CD8(+)T cells in HBV infection. | miR-199a-5p targeted regulation of MAGT1 expression in the functional depletion of CD8(+)T cells in HBV infection.
Mo Q, Yuan Z, Ning L, Wang G, Luo Q, Diao B. | 08/28/2021 |
| TRPM7 and MagT1 regulate the proliferation of osteoblast-like SaOS-2 cells through different mechanisms. | TRPM7 and MagT1 regulate the proliferation of osteoblast-like SaOS-2 cells through different mechanisms.
Zocchi M, Scrimieri R, Locatelli L, Cazzaniga A, Fedele G, Maier JAM, Castiglioni S. | 02/13/2021 |
| microRNA-199a-5p suppresses glioma progression by inhibiting MAGT1. | microRNA-199a-5p suppresses glioma progression by inhibiting MAGT1.
Wang G, Li Y, Li J, Zhang D, Luo C, Zhang B, Sun X. | 09/12/2020 |
| Authors observed that MAGT1-dependent glycosylation is sensitive to Mg(2+) levels and that reduced Mg(2+) impairs immune-cell function via the loss of specific glycoproteins. Findings reveal that defects in protein glycosylation and gene expression underlie immune defects in an inherited disease due to MAGT1 deficiency. | Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes.
Matsuda-Lennikov M, Biancalana M, Zou J, Ravell JC, Zheng L, Kanellopoulou C, Jiang P, Notarangelo G, Jing H, Masutani E, Oler AJ, Olano LR, Schulz BL, Lenardo MJ., Free PMC Article | 05/16/2020 |
| This study demonstrates that the simultaneous downregulation of TRPM7 and MagT1 inhibits cell growth and activates autophagy, which is required in the early phases of osteoblastogenesis. | The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation.
Castiglioni S, Romeo V, Locatelli L, Zocchi M, Zecchini S, Maier JAM. | 04/11/2020 |
| TRPM7 and MagT1 are upregulated in osteogenic differentiation and silencing either one accelerates osteogenic differentiation, partly through the activation of autophagy. .. These results underpin the contribution of magnesium, TRPM7 and MagT1 to autophagy and osteoblastogenesis. | TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro.
Castiglioni S, Romeo V, Locatelli L, Cazzaniga A, Maier JAM., Free PMC Article | 10/19/2019 |
| MAGT1 expression is defective in CD8+positive T cells of chronic hepatitis B patients. | MAGT1-mediated disturbance of Mg(2+) homeostasis lead to exhausted of HBV-infected NK and CD8(+) T cells.
Diao B, Huang X, Guo S, Yang C, Liu G, Chen Y, Wu Y., Free PMC Article | 07/6/2019 |
| evaluation of MAGT1 and AKAP13 expression in clinical hepatocellular carcinoma tissues by immunohistochemistry suggested that both proteins were strongly expressed in tumor tissues with significantly higher average immunoreactive scores of Remmele and Stegner (IRS) than in non-tumor tissues | Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.
Molee P, Adisakwattana P, Reamtong O, Petmitr S, Sricharunrat T, Suwandittakul N, Chaisri U., Free PMC Article | 10/1/2016 |
| A 0.8 kb intronic duplication in MAGT1 and a single base pair deletion in the last exon of ATRX were identified in a family with five males demonstrating intellectual disability (ID) and unusual skin findings (e.g., generalized pruritus). | Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.
Qiao Y, Mondal K, Trapani V, Wen J, Carpenter G, Wildin R, Price EM, Gibbons RJ, Eichmeyer J, Jiang R, DuPont B, Martell S, Lewis SM, Robinson WP, O'Driscoll M, Wolf FI, Zwick ME, Rajcan-Separovic E. | 08/9/2014 |
| A deficiency in magnesium transporter 1 (MAGT1), an Mg(2+)-specific transporter, leads to the absence of a T cell antigen receptor-stimulated Mg(2+)flux and an attenuation of T cell activation. | Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency.
Li FY, Lenardo MJ, Chaigne-Delalande B., Free PMC Article | 05/5/2012 |
| Data show that gene expression of the Mg(2+) selective transporter MagT1 is upregulated in TRPM7(-/-) cells. | The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7.
Deason-Towne F, Perraud AL, Schmitz C., Free PMC Article | 10/8/2011 |
| MagT1 is universally expressed in all tissues and its expression level is up-regulated in low extracellular Mg(2+). Knockdown of either MagT1 or TUSC3 protein significantly lowers the total and free intracellular Mg(2+) concentrations in cell lines. | Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.
Zhou H, Clapham DE., Free PMC Article | 01/21/2010 |
| study shows that mutations in two OTase-subunit genes, N33/TUSC3 and IAP result in autosomal-recessive nonsyndromic mental retardation | Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation.
Molinari F, Foulquier F, Tarpey PS, Morelle W, Boissel S, Teague J, Edkins S, Futreal PA, Stratton MR, Turner G, Matthijs G, Gecz J, Munnich A, Colleaux L., Free PMC Article | 01/21/2010 |
| identifed a novel gene that encodes a protein involved with Mg2+-evoked transport, MagT1; results suggest that MagT1 may provide a selective and regulated pathway for Mg2+ transport in epithelial cells[MagT1] | Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.
Goytain A, Quamme GA., Free PMC Article | 01/21/2010 |