| GSG2 promotes progression of human endometrial cancer by regulating PD-1/PD-L1 expression via PI3K-AKT pathway. | GSG2 promotes progression of human endometrial cancer by regulating PD-1/PD-L1 expression via PI3K-AKT pathway.
Chen H, Liu S, Wu S, Nong X, Liu N, Li L. | 06/10/2024 |
| Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3alpha-p27 cascade. | Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.
Zhu K, Ma X, Guan X, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R., Free PMC Article | 06/5/2024 |
| GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway. | GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway.
Zhang F, Huang C., Free PMC Article | 04/11/2024 |
| GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1. | GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1.
Tang Y, Dai G, Yang Y, Liu H., Free PMC Article | 08/7/2023 |
| Effects and mechanisms of GSG2 in esophageal cancer progression. | Effects and mechanisms of GSG2 in esophageal cancer progression.
Geng C, Wang Q, Xing PF, Wang M, Tong SD, Zhou JY. | 07/7/2023 |
| Knockdown of GSG2 inhibits the development and progression of non-small cell lung cancer in vitro and in vivo. | Knockdown of GSG2 inhibits the development and progression of non-small cell lung cancer in vitro and in vivo.
Zhang F, Qiu B, Ji Y, Zhang H, Song P, Sun N, Zhao L, Lv F, Yin L, Gao Y, Xue Q, Gao S, He J., Free PMC Article | 01/11/2023 |
| Knockdown of GSG2 Suppresses the Progression of Colorectal Cancer Cells. | Knockdown of GSG2 Suppresses the Progression of Colorectal Cancer Cells.
Yu W, Liu W, Feng Y, Zhu C. | 03/19/2022 |
| GSG2 knockdown suppresses cholangiocarcinoma progression by regulating cell proliferation, apoptosis and migration. | GSG2 knockdown suppresses cholangiocarcinoma progression by regulating cell proliferation, apoptosis and migration.
Zhou J, Nie W, Yuan J, Zhang Z, Mi L, Wang C, Huang R., Free PMC Article | 11/6/2021 |
| Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages. | Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages.
Wang P, Hua X, Sun Y, Li H, Bryner YH, Hsung RP, Dai J. | 10/30/2021 |
| Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation. | Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation.
Quadri R, Sertic S, Ghilardi A, Rondelli D, Gallo GR, Del Giacco L, Muzi-Falconi M., Free PMC Article | 08/7/2021 |
| GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12). | GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).
Chen Y, Fu D, Zhao H, Cheng W, Xu F., Free PMC Article | 08/7/2021 |
| Knockdown of GSG2 inhibits prostate cancer progression in vitro and in vivo. | Knockdown of GSG2 inhibits prostate cancer progression in vitro and in vivo.
Yu F, Lin Y, Xu X, Liu W, Tang D, Zhou X, Wang G, Zheng Y, Xie A., Free PMC Article | 03/13/2021 |
| HASPIN is involved in the progression of gallbladder carcinoma. | HASPIN is involved in the progression of gallbladder carcinoma.
Zhu D, Gu X, Lin Z, Yu D, Wang J, Li L. | 12/12/2020 |
| Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. | Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition.
Huang M, Feng X, Su D, Wang G, Wang C, Tang M, Paulucci-Holthauzen A, Hart T, Chen J., Free PMC Article | 11/28/2020 |
| Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis. | Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis.
Hadders MA, Hindriksen S, Truong MA, Mhaskar AN, Wopken JP, Vromans MJM, Lens SMA., Free PMC Article | 10/24/2020 |
| GSG2 upregulation was associated with pancreatic cancer progression. | Haspin knockdown can inhibit progression and development of pancreatic cancer in vitro and vivo.
Han X, Kuang T, Ren Y, Lu Z, Liao Q, Chen W. | 06/20/2020 |
| The results indicate a kinase-dependent role for Haspin in antagonizing Wapl and protecting centromeric cohesion in mitosis. | A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.
Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F., Free PMC Article | 01/5/2019 |
| The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. | Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
Goto Y, Yamagishi Y, Shintomi-Kawamura M, Abe M, Tanno Y, Watanabe Y. | 07/14/2018 |
| The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. | The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis.
Zhou L, Liang C, Chen Q, Zhang Z, Zhang B, Yan H, Qi F, Zhang M, Yi Q, Guan Y, Xiang X, Zhang X, Ye S, Wang F. | 07/14/2018 |
| Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP | High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.
Lew YJ, Rinella N, Qin J, Chiang J, Moore AT, Porco TC, Roorda A, Duncan JL., Free PMC Article | 12/30/2017 |
| This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors | Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
Lavogina D, Kestav K, Chaikuad A, Heroven C, Knapp S, Uri A., Free PMC Article | 04/15/2017 |
| Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool. | Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
Bekier ME, Mazur T, Rashid MS, Taylor WR., Free PMC Article | 04/9/2016 |
| Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing. | Modulation of the chromatin phosphoproteome by the Haspin protein kinase.
Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R., Free PMC Article | 10/24/2015 |
| Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling | Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.
Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM., Free PMC Article | 01/12/2013 |
| Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis | A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.
Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM., Free PMC Article | 10/22/2011 |