| Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose. | Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
Carrier DJ, van Roermund CWT, Schaedler TA, Rong HL, IJlst L, Wanders RJA, Baldwin SA, Waterham HR, Theodoulou FL, Baker A., Free PMC Article | 11/21/2020 |
| Peroxisomal ATP-binding cassette transporter COMATOSE is required for the accumulation of benzoylated secondary metabolites in Arabidopsis seeds, including benzoylated glucosinolates and substituted hydroxybenzoylcholines. | Peroxisomal ATP-binding cassette transporter COMATOSE and the multifunctional protein abnormal INFLORESCENCE MERISTEM are required for the production of benzoylated metabolites in Arabidopsis seeds.
Bussell JD, Reichelt M, Wiszniewski AA, Gershenzon J, Smith SM., Free PMC Article | 10/25/2014 |
| Data indicate that CGI-58 (At4g24160) interacts with PXA1 into peroxisomes for their subsequent metabolism by beta-oxidation, including fatty acids and lipophilic hormone precursors of the jasmonate and auxin biosynthetic pathways. | The α/β hydrolase CGI-58 and peroxisomal transport protein PXA1 coregulate lipid homeostasis and signaling in Arabidopsis.
Park S, Gidda SK, James CN, Horn PJ, Khuu N, Seay DC, Keereetaweep J, Chapman KD, Mullen RT, Dyer JM., Free PMC Article | 02/1/2014 |
| Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity | Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity.
Nyathi Y, Zhang X, Baldwin JM, Bernhardt K, Johnson B, Baldwin SA, Theodoulou FL, Baker A. | 10/13/2012 |
| The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity. | The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
Nyathi Y, De Marcos Lousa C, van Roermund CW, Wanders RJ, Johnson B, Baldwin SA, Theodoulou FL, Baker A., Free PMC Article | 10/23/2010 |
| PED3 promotes seed germination by suppressing polygalacturonase inhibiting proteins under the control of ABI5. | A peroxisomal ABC transporter promotes seed germination by inducing pectin degradation under the control of ABI5.
Kanai M, Nishimura M, Hayashi M. | 10/4/2010 |
| pxa1 plants accumulate free fatty acids in dark-treated leaves. Extended dark conditions are lethal for pxa1 plants. | The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness.
Kunz HH, Scharnewski M, Feussner K, Feussner I, Flügge UI, Fulda M, Gierth M., Free PMC Article | 01/21/2010 |
| Results demonstrate that COMATOSE functions can be separated by mutagenesis and the structural model provides a framework for interpretation of phenotypic data. | Mutations in the Arabidopsis peroxisomal ABC transporter COMATOSE allow differentiation between multiple functions in planta: insights from an allelic series.
Dietrich D, Schmuths H, De Marcos Lousa C, Baldwin JM, Baldwin SA, Baker A, Theodoulou FL, Holdsworth MJ., Free PMC Article | 01/21/2010 |
| pxa1 mutants are sucrose-dependent and IBA resistant following germination, probably because of a failure to import beta-oxidation substrates into peroxisomes. | The Arabidopsis pxa1 mutant is defective in an ATP-binding cassette transporter-like protein required for peroxisomal fatty acid beta-oxidation.
Zolman BK, Silva ID, Bartel B., Free PMC Article | 03/28/2008 |
| Beta-oxidation could play a role in the mobilization of lipids in both pollen and female tissues. Expression of CTS in either male or female tissues was sufficient to support pollen tube growth in vivo. | The COMATOSE ATP-binding cassette transporter is required for full fertility in Arabidopsis.
Footitt S, Dietrich D, Fait A, Fernie AR, Holdsworth MJ, Baker A, Theodoulou FL., Free PMC Article | 01/21/2010 |
| CTS has a role following after-ripening within pathways related to the progression of germination prior to radicle emergence. | Analysis of the role of COMATOSE and peroxisomal beta-oxidation in the determination of germination potential in Arabidopsis.
Footitt S, Marquez J, Schmuths H, Baker A, Theodoulou FL, Holdsworth M. | 01/21/2010 |
| The role of the transporter COMATOSE in the biosynthesis of Jasmonic acid in A. thaliana leaves is described. [COMATOSE] [CTS] | Jasmonic acid levels are reduced in COMATOSE ATP-binding cassette transporter mutants. Implications for transport of jasmonate precursors into peroxisomes.
Theodoulou FL, Job K, Slocombe SP, Footitt S, Holdsworth M, Baker A, Larson TR, Graham IA., Free PMC Article | 01/21/2010 |