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    CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 829, updated on 5-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.

    Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
    Zhang C, Wei G, Zhu X, Chen X, Ma X, Hu P, Liu W, Yang W, Ruan T, Zhang W, Wu C, Tao K., Free PMC Article

    01/21/2023
    Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.

    Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
    Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J., Free PMC Article

    01/22/2022
    A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.

    A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.
    Funk J, Merino F, Schaks M, Rottner K, Raunser S, Bieling P., Free PMC Article

    10/9/2021
    in CAPZA1-overexpressing gastric epithelial cells infected with H. pylori, autolysosome formation is inhibited and CagA escapes autophagic degradation.

    CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.
    Tsugawa H, Mori H, Matsuzaki J, Sato A, Saito Y, Imoto M, Suematsu M, Suzuki H., Free PMC Article

    03/7/2020
    Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells.

    CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.
    Huang D, Cao L, Zheng S., Free PMC Article

    12/16/2017
    Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2.

    Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.
    Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI., Free PMC Article

    10/22/2016
    mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.

    Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end.
    Bombardier JP, Eskin JA, Jaiswal R, Corrêa IR Jr, Xu MQ, Goode BL, Gelles J., Free PMC Article

    07/2/2016
    The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.

    Prognostic value of CAPZA1 overexpression in gastric cancer.
    Lee YJ, Jeong SH, Hong SC, Cho BI, Ha WS, Park ST, Choi SK, Jung EJ, Ju YT, Jeong CY, Kim JW, Lee CW, Yoo J, Ko GH., Free PMC Article

    11/2/2013
    CAPAZA1 is over expressed in malignant melanoma.

    Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
    Sun D, Zhou M, Kowolik CM, Trisal V, Huang Q, Kernstine KH, Lian F, Shen B., Free PMC Article

    10/29/2011
    Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management.

    Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.
    Mahoney DJ, Safdar A, Parise G, Melov S, Fu M, MacNeil L, Kaczor J, Payne ET, Tarnopolsky MA., Free PMC Article

    01/21/2010
    Cd2 antigen is linked to this protein via CMS and CIN85.

    Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.
    Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH.

    01/21/2010
    CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein

    The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.
    Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW., Free PMC Article

    01/21/2010
    V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein

    V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.
    Taoka M, Ichimura T, Wakamiya-Tsuruta A, Kubota Y, Araki T, Obinata T, Isobe T.

    01/21/2010
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