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    ARID1A AT-rich interaction domain 1A [ Homo sapiens (human) ]

    Gene ID: 8289, updated on 5-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ARID1A-Deficient Tumors Acquire Immunogenic Neoantigens during the Development of Resistance to Targeted Therapy.

    ARID1A-Deficient Tumors Acquire Immunogenic Neoantigens during the Development of Resistance to Targeted Therapy.
    Okada M, Yamasaki S, Nakazato H, Hirahara Y, Ishibashi T, Kawamura M, Shimizu K, Fujii SI.

    10/25/2024
    ARID1A restrains EMT and stemness of ovarian cancer cells through the Hippo pathway.

    ARID1A restrains EMT and stemness of ovarian cancer cells through the Hippo pathway.
    Xu S, Zhu C, Xu Q, An Z, Xu S, Xuan G, Lin C, Tang C., Free PMC Article

    10/1/2024
    ARID1A in Gynecologic Precancers and Cancers.

    ARID1A in Gynecologic Precancers and Cancers.
    Morgan JE, Jaferi N, Shonibare Z, Huang GS.

    07/31/2024
    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.

    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
    Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC.,

    07/2/2024
    Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma.

    Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma.
    Li S, Meersma GJ, Kupryjanczyk J, de Jong S, Wisman GBA., Free PMC Article

    06/20/2024
    Prognostic role of transcription factor ARID1A in patients with endometrial cancer of no specific molecular profile (NSMP) subtype.

    Prognostic role of transcription factor ARID1A in patients with endometrial cancer of no specific molecular profile (NSMP) subtype.
    Onoprienko A, Hofstetter G, Muellauer L, Dorittke T, Polterauer S, Grimm C, Bartl T.

    06/12/2024
    ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response.

    ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response.
    Bakr A, Della Corte G, Veselinov O, Kelekçi S, Chen MM, Lin YY, Sigismondo G, Iacovone M, Cross A, Syed R, Jeong Y, Sollier E, Liu CS, Lutsik P, Krijgsveld J, Weichenhan D, Plass C, Popanda O, Schmezer P., Free PMC Article

    06/11/2024
    Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real-world study.

    Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real-world study.
    Ottaiano A, Santorsola M, Diana A, Belli A, Lentini Graziano ML, Orefice J, Patrone R, Di Mauro A, Scognamiglio G, Tatangelo F, De Bellis M, Piccirillo M, Fiore F, Stilo S, Tarotto L, Correra M, Di Lorenzo S, Capuozzo M, Avallone A, Silvestro L, Bianco A, Granata V, Federico P, Montesarchio V, Daniele B, Izzo F, Nasti G., Free PMC Article

    04/24/2024
    Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma.

    Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma.
    Xiao M, Cui X, Xu C, Xin L, Zhao J, Yang S, Hong B, Tan Y, Zhang J, Li X, Li J, Kang C, Fang C., Free PMC Article

    04/18/2024
    ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.

    ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
    Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A.,

    04/16/2024
    Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.

    Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.
    D'Ambrosio A, Bressan D, Ferracci E, Carbone F, Mulè P, Rossi F, Barbieri C, Sorrenti E, Fiaccadori G, Detone T, Vezzoli E, Bianchi S, Sartori C, Corso S, Fukuda A, Bertalot G, Falqui A, Barbareschi M, Romanel A, Pasini D, Chiacchiera F., Free PMC Article

    03/20/2024
    The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.

    The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.
    Zhang J, Chen F, Tang M, Xu W, Tian Y, Liu Z, Shu Y, Yang H, Zhu Q, Lu X, Peng B, Liu X, Xu X, Gullerova M, Zhu WG.

    03/5/2024
    ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.

    ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.
    Nguyen V, Schrank TP, Major MB, Weissman BE., Free PMC Article

    02/23/2024
    ARID1A loss induces P4HB to activate fibroblasts to support lung cancer cell growth, invasion, and chemoresistance.

    ARID1A loss induces P4HB to activate fibroblasts to support lung cancer cell growth, invasion, and chemoresistance.
    Huang R, Wu D, Zhang K, Hu G, Liu Y, Jiang Y, Wang C, Zheng Y., Free PMC Article

    02/16/2024
    The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis.

    The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis.
    Li JJ, Lee CS., Free PMC Article

    02/6/2024
    ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma.

    ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma.
    Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, Xu Y, Gao X, Dong G, Xia X, Guan Y, Zhang L, Wen Z, Liang J., Free PMC Article

    01/17/2024
    ARID1A loss activates MAPK signaling via DUSP4 downregulation.

    ARID1A loss activates MAPK signaling via DUSP4 downregulation.
    Mandal J, Yu ZC, Shih IM, Wang TL., Free PMC Article

    12/28/2023
    Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer.

    Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer.
    Anabel Sinberger L, Zahavi T, Sonnenblick A, Salmon-Divon M., Free PMC Article

    12/1/2023
    Explore the alterations of downstream molecular pathways caused by ARID1A mutation/knockout in human endometrial cancer cells.

    Explore the alterations of downstream molecular pathways caused by ARID1A mutation/knockout in human endometrial cancer cells.
    Xing B, Zhang X, Gu X, Xiang L, Wang C, Jin Y.

    11/30/2023
    Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma.

    Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma.
    Xing T, Li L, Chen Y, Ju G, Li G, Zhu X, Ren Y, Zhao J, Cheng Z, Li Y, Xu D, Liang J., Free PMC Article

    11/27/2023
    Clinicopathologic Features and the Loss of ARID1A Expression in Ovarian Seromucinous Borderline Tumors and Seromucinous Carcinomas.

    Clinicopathologic Features and the Loss of ARID1A Expression in Ovarian Seromucinous Borderline Tumors and Seromucinous Carcinomas.
    Ok Atılgan A, Özen Ö, Haberal Reyhan AN, Ayhan A.

    10/20/2023
    Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.

    Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.
    Chen XY, Li B, Wang Y, Jin J, Yang Y, Huang LH, Yang MD, Zhang J, Wang BY, Shao ZM, Ni T, Huang SL, Hu XC, Tao ZH., Free PMC Article

    09/21/2023
    ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications.

    ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications.
    Jin F, Yang Z, Shao J, Tao J, Reißfelder C, Loges S, Zhu L, Schölch S.

    09/12/2023
    CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.

    CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.
    Kobayashi K, Saito Y, Kage H, Fukuoka O, Yamamura K, Mukai T, Oda K, Yamasoba T.

    09/6/2023
    Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.

    Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
    Xu C, Huang KK, Law JH, Chua JS, Sheng T, Flores NM, Pizzi MP, Okabe A, Tan ALK, Zhu F, Kumar V, Lu X, Benitez AM, Lian BSX, Ma H, Ho SWT, Ramnarayanan K, Anene-Nzelu CG, Razavi-Mohseni M, Abdul Ghani SAB, Tay ST, Ong X, Lee MH, Guo YA, Ashktorab H, Smoot D, Li S, Skanderup AJ, Beer MA, Foo RSY, Wong JSH, Sanghvi K, Yong WP, Sundar R, Kaneda A, Prabhakar S, Mazur PK, Ajani JA, Yeoh KG, So JB, Tan P, Singapore Gastric Cancer Consortium.

    08/10/2023
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