| HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to promote WNT signaling. | HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to promote WNT signaling.
Broniarczyk J, Trejo-Cerro O, Massimi P, Kavčič N, Myers MP, Banks L., Free PMC Article | 08/23/2024 |
| Circular RNA SNX27 Facilitates Gastric Cancer Progression By Sponging miR-638. | Circular RNA SNX27 Facilitates Gastric Cancer Progression By Sponging miR-638.
Xi Y, Gai Y, Zhang W, Wang M, Liu Q, Bi Y., Free PMC Article | 08/22/2024 |
| HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation. | HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
Broniarczyk JK, Massimi P, Trejo-Cerro O, Myers MP, Banks L., Free PMC Article | 12/10/2022 |
| Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis. | Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis.
Li H, Liu B, Xu X, Li S, Zhang D, Liu Q. | 11/19/2022 |
| Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus. | Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus.
Chandra M, Collins BM, Jackson LP., Free PMC Article | 04/16/2022 |
| Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse. | Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse.
González-Mancha N, Rodríguez-Rodríguez C, Alcover A, Merida I., Free PMC Article | 03/12/2022 |
| SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. | SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry.
Yang B, Jia Y, Meng Y, Xue Y, Liu K, Li Y, Liu S, Li X, Cui K, Shang L, Cheng T, Zhang Z, Hou Y, Yang X, Yan H, Duan L, Tong Z, Wu C, Liu Z, Gao S, Zhuo S, Huang W, Gao GF, Qi J, Shang G., Free PMC Article | 01/29/2022 |
| Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling. | Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling.
Mao L, Liao C, Qin J, Gong Y, Zhou Y, Li S, Liu Z, Deng H, Deng W, Sun Q, Mo X, Xue Y, Billadeau DD, Dai L, Li G, Jia D., Free PMC Article | 09/25/2021 |
| Sorting Nexin 27 as a potential target in G proteincoupled receptor recycling for cancer therapy (Review). | Sorting Nexin 27 as a potential target in G protein‑coupled receptor recycling for cancer therapy (Review).
Bao Z, Zhou S, Zhou H., Free PMC Article | 07/10/2021 |
| Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. | Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS.
González-Mancha N, Mérida I., Free PMC Article | 02/20/2021 |
| Sorting nexin 27 (SNX27) variants associated with seizures, developmental delay, behavioral disturbance, and subcortical brain abnormalities. | Sorting nexin 27 (SNX27) variants associated with seizures, developmental delay, behavioral disturbance, and subcortical brain abnormalities.
Parente DJ, Morris SM, McKinstry RC, Brandt T, Gabau E, Ruiz A, Shinawi M. | 02/6/2021 |
| The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27. | The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27.
Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT., Free PMC Article | 11/21/2020 |
| SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling. | SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT., Free PMC Article | 10/24/2020 |
| SNX27 directly interacts with DRA in early endosomes at the apical pole of intestinal Caco2 cells and mediates its direct recycling to facilitate high activity in lipid rafts in the apical plasma membrane. | SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells.
Bannert K, Berlin P, Reiner J, Lemcke H, David R, Engelmann R, Lamprecht G. | 08/1/2020 |
| High SNX27 expression is associated with breast cancer metastasis. | SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.
Sharma P, Parveen S, Shah LV, Mukherjee M, Kalaidzidis Y, Kozielski AJ, Rosato R, Chang JC, Datta S., Free PMC Article | 08/1/2020 |
| Authors define an additional, non-catalytic function of OTULIN in the regulation of SNX27-retromer assembly and recycling to the cell surface. | Regulation of the endosomal SNX27-retromer by OTULIN.
Stangl A, Elliott PR, Pinto-Fernandez A, Bonham S, Harrison L, Schaub A, Kutzner K, Keusekotten K, Pfluger PT, El Oualid F, Kessler BM, Komander D, Krappmann D., Free PMC Article | 01/11/2020 |
| these data have demonstrate that SNX27 plays a crucial role in breast cancer growth in vitro and in vivo | Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo.
Zhang J, Li K, Zhang Y, Lu R, Wu S, Tang J, Xia Y, Sun J., Free PMC Article | 12/28/2019 |
| HTLV-1 Tax-1 alters GLUT1 localization via its interaction with SNX27. We demonstrate that over expression of Tax-1 in cells causes a reduction of GLUT1 on the plasma membrane. Furthermore, we show that knockdown of SNX27 results in increased virion release and decreased HTLV-1 infectivity. | HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1.
Al-Saleem J, Dirksen WP, Martinez MP, Shkriabai N, Kvaratskhelia M, Ratner L, Green PL., Free PMC Article | 12/14/2019 |
| crystal structure of human SNX27 PX domain by X-ray crystallography | Crystal Structure of the PX Domain of SNX27.
Li Y, Liao S, Li F, Zhu Z. | 07/27/2019 |
| This study broadens our understanding of SNX27 as an integrator of lipid-based signals with the control of transcription and metabolic pathways. | SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes.
Tello-Lafoz M, Rodríguez-Rodríguez C, Kinna G, Loo LS, Hong W, Collins BM, Teasdale RD, Mérida I., Free PMC Article | 07/13/2019 |
| data reveal a role for SNX27 in glutamine uptake and amino acid-stimulated mTORC1 activation via modulation of ASCT2 intracellular trafficking | Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2.
Yang Z, Follett J, Kerr MC, Clairfeuille T, Chandra M, Collins BM, Teasdale RD., Free PMC Article | 02/2/2019 |
| Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS | Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I. | 04/7/2018 |
| Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation. | SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.
Meraviglia V, Ulivi AF, Boccazzi M, Valenza F, Fratangeli A, Passafaro M, Lecca D, Stagni F, Giacomini A, Bartesaghi R, Abbracchio MP, Ceruti S, Rosa P. | 01/6/2018 |
| The viral oncoprotein E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells. | Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways.
Ganti K, Massimi P, Manzo-Merino J, Tomaić V, Pim D, Playford MP, Lizano M, Roberts S, Kranjec C, Doorbar J, Banks L., Free PMC Article | 09/30/2017 |
| This study defines specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain. | A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.
Clairfeuille T, Mas C, Chan AS, Yang Z, Tello-Lafoz M, Chandra M, Widagdo J, Kerr MC, Paul B, Mérida I, Teasdale RD, Pavlos NJ, Anggono V, Collins BM. | 05/13/2017 |