| TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation. | TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation.
Wu F, Xu J, Jin X, Zhu Y, Gao W, Liu M, Zhang Y, Qian W, Huang X, Zhao D, Feng G, Hou S, Xi X., Free PMC Article | 10/17/2024 |
| Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1alpha. | Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α.
Peng Y, Qian H, Xu WP, Xiao MC, Ding CH, Liu F, Hong HY, Liu SQ, Zhang X, Xie WF., Free PMC Article | 07/1/2024 |
| TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4alpha stability. | TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.
Xiao MC, Jiang N, Chen LL, Liu F, Liu SQ, Ding CH, Wu SH, Wang KQ, Luo YY, Peng Y, Yan FZ, Zhang X, Qian H, Xie WF. | 04/25/2024 |
| Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination. | Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
Wang L, Li H, Huang A, Zhao Y, Xiao C, Dong J, Liu X, Shao N. | 12/21/2023 |
| TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt. | TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt.
Hosseinalizadeh H, Mohamadzadeh O, Kahrizi MS, Razaghi Bahabadi Z, Klionsky DJ, Mirzei H., Free PMC Article | 02/4/2023 |
| Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway. | Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.
Lu B, Li J, Gui M, Yao L, Fan M, Zhou X, Fu D., Free PMC Article | 09/10/2022 |
| Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma. | Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.
Quan L, Ren G, Liu L, Huang W, Li M. | 07/16/2022 |
| Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia. | Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.
Ding C, Zhang C, Kopp R, Kuney L, Meng Q, Wang L, Xia Y, Jiang Y, Dai R, Min S, Yao WD, Wong ML, Ruan H, Liu C, Chen C., Free PMC Article | 01/29/2022 |
| TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma. | TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.
Seong BKA, Dharia NV, Lin S, Donovan KA, Chong S, Robichaud A, Conway A, Hamze A, Ross L, Alexe G, Adane B, Nabet B, Ferguson FM, Stolte B, Wang EJ, Sun J, Darzacq X, Piccioni F, Gray NS, Fischer ES, Stegmaier K., Free PMC Article | 01/8/2022 |
| Knockdown of TRIM8 Attenuates IL-1beta-induced Inflammatory Response in Osteoarthritis Chondrocytes Through the Inactivation of NF-kappaB Pathway. | Knockdown of TRIM8 Attenuates IL-1β-induced Inflammatory Response in Osteoarthritis Chondrocytes Through the Inactivation of NF-κB Pathway.
Liu R, Wu H, Song H., Free PMC Article | 07/24/2021 |
| De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. | De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.
Weng PL, Majmundar AJ, Khan K, Lim TY, Shril S, Jin G, Musgrove J, Wang M, Ahram DF, Aggarwal VS, Bier LE, Heinzen EL, Onuchic-Whitford AC, Mann N, Buerger F, Schneider R, Deutsch K, Kitzler TM, Klämbt V, Kolb A, Mao Y, Moufawad El Achkar C, Mitrotti A, Martino J, Beck BB, Altmüller J, Benz MR, Yano S, Mikati MA, Gunduz T, Cope H, Shashi V, Undiagnosed Diseases Network, Trachtman H, Bodria M, Caridi G, Pisani I, Fiaccadori E, AbuMaziad AS, Martinez-Agosto JA, Yadin O, Zuckerman J, Kim A, UCLA Clinical Genomics Center, John-Kroegel U, Tyndall AV, Parboosingh JS, Innes AM, Bierzynska A, Koziell AB, Muorah M, Saleem MA, Hoefele J, Riedhammer KM, Gharavi AG, Jobanputra V, Pierce-Hoffman E, Seaby EG, O'Donnell-Luria A, Rehm HL, Mane S, D'Agati VD, Pollak MR, Ghiggeri GM, Lifton RP, Goldstein DB, Davis EE, Hildebrandt F, Sanna-Cherchi S., Free PMC Article | 02/20/2021 |
| Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis. | Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.
Li L, He Y, He XJ, Bi MR, Qi YH, Zhu WW. | 02/6/2021 |
| TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. | TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
Venuto S, Monteonofrio L, Cozzolino F, Monti M, Appolloni I, Mazza T, Canetti D, Giambra V, Panelli P, Fusco C, Squeo GM, Croce AI, Pucci P, Malatesta P, Soddu S, Merla G, Micale L. | 10/10/2020 |
| The findings uncover a previously unknown regulatory mechanism of type I interferon production in Plasmacytoid dendritic cells by which TRIM8 and Pin1 oppositely regulate the stability of interferon regulatory factor 7. | TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells.
Maarifi G, Smith N, Maillet S, Moncorgé O, Chamontin C, Edouard J, Sohm F, Blanchet FP, Herbeuval JP, Lutfalla G, Levraud JP, Arhel NJ, Nisole S., Free PMC Article | 05/16/2020 |
| TRIM8 is a novel gene responsible for epileptic encephalopathy, possibly associated with nephrotic syndrome. | Further delineation of the clinical spectrum of de novo TRIM8 truncating mutations.
Assoum M, Lines MA, Elpeleg O, Darmency V, Whiting S, Edvardson S, Devinsky O, Heinzen E, Hernan RR, Antignac C, Deleuze JF, Des Portes V, Bertholet-Thomas A, Belot A, Geller E, Lemesle M, Duffourd Y, Thauvin-Robinet C, Thevenon J, Chung W, Lowenstein DH, Faivre L. | 09/28/2019 |
| In the current study the authors identified TRIM8, RING E3 Ligase, as a novel regulator of autophagy during DNA damage response. | TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death.
Roy M, Tomar D, Singh K, Lakshmi S, Prajapati P, Bhatelia K, Gohel D, Singh R. | 09/21/2019 |
| TRIM8 knockdown effectively protected lipopolysaccharide-induced acute liver failure against inflammation and oxidative stress largely dependent on the promotion of AMPKalpha pathway. | Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity.
Xiaoli L, Wujun Z, Jing L. | 09/14/2019 |
| TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. | TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ., Free PMC Article | 10/28/2017 |
| we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC. | TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.
Mastropasqua F, Marzano F, Valletti A, Aiello I, Di Tullio G, Morgano A, Liuni S, Ranieri E, Guerrini L, Gasparre G, Sbisà E, Pesole G, Moschetta A, Caratozzolo MF, Tullo A., Free PMC Article | 07/29/2017 |
| A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain. | De Novo Truncating Mutation of TRIM8 Causes Early-Onset Epileptic Encephalopathy.
Sakai Y, Fukai R, Matsushita Y, Miyake N, Saitsu H, Akamine S, Torio M, Sasazuki M, Ishizaki Y, Sanefuji M, Torisu H, Shaw CA, Matsumoto N, Hara T. | 05/27/2017 |
| Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. | TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.
Micale L, Fusco C, Fontana A, Barbano R, Augello B, De Nittis P, Copetti M, Pellico MT, Mandriani B, Cocciadiferro D, Parrella P, Fazio VM, Dimitri LM, D'Angelo V, Novielli C, Larizza L, Daga A, Merla G., Free PMC Article | 02/27/2016 |
| These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma | TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma.
Caratozzolo MF, Valletti A, Gigante M, Aiello I, Mastropasqua F, Marzano F, Ditonno P, Carrieri G, Simonnet H, D'Erchia AM, Ranieri E, Pesole G, Sbisà E, Tullo A., Free PMC Article | 08/8/2015 |
| Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway. | Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway.
Tomar D, Sripada L, Prajapati P, Singh R, Singh AK, Singh R., Free PMC Article | 05/4/2013 |
| TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein. | TRIM8 modulates p53 activity to dictate cell cycle arrest.
Caratozzolo MF, Micale L, Turturo MG, Cornacchia S, Fusco C, Marzano F, Augello B, D'Erchia AM, Guerrini L, Pesole G, Sbisà E, Merla G, Tullo A. | 09/15/2012 |
| Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. | Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.
Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB, Wang YY., Free PMC Article | 01/28/2012 |