| A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding. | A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.
Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM., Free PMC Article | 01/11/2023 |
| CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis. | CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.
Ma L, Li H, Lin Y, Wang G, Xu Q, Chen Y, Xiao K, Rao X. | 09/11/2021 |
| DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo. | DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo.
Wang X, Broxmeyer HE., Free PMC Article | 06/19/2021 |
| DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. | DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death.
Low HB, Wong ZL, Wu B, Kong LR, Png CW, Cho YL, Li CW, Xiao F, Xin X, Yang H, Loo JM, Lee FYX, Tan IBH, DasGupta R, Shen HM, Schwarz H, Gascoigne NRJ, Goh BC, Xu X, Zhang Y., Free PMC Article | 05/8/2021 |
| Chemotherapy increased DUSP9 expression and decreased DUSP16 expression in a HIF1-dependent manner. | Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment.
Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y, Semenza GL. | 08/31/2019 |
| The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported. | A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation.
Liu X, Zhang CS, Lu C, Lin SC, Wu JW, Wang ZX., Free PMC Article | 08/13/2016 |
| The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci. | DUSP16 ablation arrests the cell cycle and induces cellular senescence.
Zhang H, Zheng H, Mu W, He Z, Yang B, Ji Y, Hui L. | 06/11/2016 |
| analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha | Structural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solution.
Kumar GS, Zettl H, Page R, Peti W., Free PMC Article | 12/28/2013 |
| PPARdelta-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK signaling. | PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling.
Ham SA, Kang ES, Lee H, Hwang JS, Yoo T, Paek KS, Park C, Kim JH, Lim DS, Seo HG. | 12/28/2013 |
| Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. | A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.
Bose AK, Janes KA., Free PMC Article | 08/31/2013 |
| Data indicate that LRP6, BCL2L14, DUSP16, CREBL2, and CDKN1B were involed in centromeric (12p11.21-12p13.2) deletion in ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia (BCP-ALL). | Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.
Al-Shehhi H, Konn ZJ, Schwab CJ, Erhorn A, Barber KE, Wright SL, Gabriel AS, Harrison CJ, Moorman AV. | 05/25/2013 |
| MKP-7, a negative regulator of JNK, regulates VCAM-1 expression in activated endothelial cells through IRF-1 but not GATA6. | MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1.
Nizamutdinova IT, Kim YM, Lee JH, Chang KC, Kim HJ. | 06/30/2012 |
| DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. | Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases.
Finch AR, Caunt CJ, Perrett RM, Tsaneva-Atanasova K, McArdle CA., Free PMC Article | 06/9/2012 |
| DUSP16 is a new epigenetically regulated determinant of JNK activation in BL. | DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma.
Lee S, Syed N, Taylor J, Smith P, Griffin B, Baens M, Bai M, Bourantas K, Stebbing J, Naresh K, Nelson M, Tuthill M, Bower M, Hatzimichael E, Crook T., Free PMC Article | 08/9/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| MKP-7 down-regulates ERK-dependent gene expression by blocking nuclear accumulation of phospho-ERK. | MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.
Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H. | 03/22/2010 |
| identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration | SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.
Pi X, Wu Y, Ferguson JE 3rd, Portbury AL, Patterson C., Free PMC Article | 01/21/2010 |
| context-dependent role for DUSP16 on cell transformation and apoptosis. | MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.
Hoornaert I, Marynen P, Goris J, Sciot R, Baens M. | 01/21/2010 |
| MKP7 binds beta-arrestin 2 via amino acids 394-443 of MKP7, the same region that interacts with JIP-1 | Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2.
Willoughby EA, Collins MK. | 01/21/2010 |
| activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation | Phosphorylation of Ser-446 determines stability of MKP-7.
Katagiri C, Masuda K, Urano T, Yamashita K, Araki Y, Kikuchi K, Shima H. | 01/21/2010 |