| Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease. | Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease.
Fu X, Qu L, Xu H, Xie J. | 04/3/2024 |
| NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation. | NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation.
Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W., Free PMC Article | 04/5/2023 |
| Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells. | Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells.
Tang YL, Zhu L, Yang HF, Tao Y, Lu W, Cheng H. | 03/8/2023 |
| UBA6 and NDFIP1 regulate the degradation of ferroportin. | UBA6 and NDFIP1 regulate the degradation of ferroportin.
Traeger L, Wiegand SB, Sauer AJ, Corman BHP, Peneyra KM, Wunderer F, Fischbach A, Bagchi A, Malhotra R, Zapol WM, Bloch DB., Free PMC Article | 04/16/2022 |
| Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients. | Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients.
López-Cotarelo P, González-Jiménez A, Agudo-Jiménez T, Abarca-Zabalía J, Aladro Y, Pilo B, Comabella M, Espino-Paisán L, Urcelay E., Free PMC Article | 01/29/2022 |
| We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages. We show that allosteric activation by NDFIP1 or engineered ubiquitin variants is largely mediated by relief of WW domain linker autoinhibition. | Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.
Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA., Free PMC Article | 06/13/2020 |
| we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells | MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression.
Peng J, Liu H, Liu C., Free PMC Article | 11/3/2018 |
| the expression of Ndfipl reduced expression of a-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models. | Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson's disease model.
Xing LF, Guo HP, Wang DT, Sun LH, Pan SY. | 02/4/2017 |
| Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin secretion. These effects were associated with an increase in the cellular content of JunB, a potent inhibitor of ER stress and apoptosis. | Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y. | 04/16/2016 |
| Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi. | Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
Kang Y, Guo J, Yang T, Li W, Zhang S. | 04/2/2016 |
| Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus. | Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS., Free PMC Article | 05/30/2015 |
| In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes. | Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.
Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS., Free PMC Article | 02/21/2015 |
| Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation. | Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.
Wang Y, Tong X, Ye X. | 01/26/2013 |
| Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes. | Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS., Free PMC Article | 05/14/2011 |
| PTEN/Akt and MAP kinase signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 | Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Mund T, Pelham HR., Free PMC Article | 07/26/2010 |
| Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1. | Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS., Free PMC Article | 01/21/2010 |
| Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them. | Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
Mund T, Pelham HR., Free PMC Article | 01/21/2010 |
| Ndfip1 is required for the exosomal secretion of Nedd4 family proteins | Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS. | 01/21/2010 |