| Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. | Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel Ö, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF., Free PMC Article | 08/16/2024 |
| Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. | Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly.
Gross A, Müller J, Chrustowicz J, Strasser A, Gottemukkala KV, Sherpa D, Schulman BA, Murray PJ, Alpi AF., Free PMC Article | 06/5/2024 |
| Two Novel Variants of WDR26 in Chinese Patients with Intellectual Disability. | Two Novel Variants of WDR26 in Chinese Patients with Intellectual Disability.
Hu J, Xu M, Zhu X, Zhang Y., Free PMC Article | 09/3/2022 |
| Skraban-Deardorff syndrome: Six new cases of WDR26-related disease and expansion of the clinical phenotype. | Skraban-Deardorff syndrome: Six new cases of WDR26-related disease and expansion of the clinical phenotype.
Cospain A, Schaefer E, Faoucher M, Dubourg C, Carré W, Bizaoui V, Assoumani J, Van Maldergem L, Piton A, Gérard B, Tran Mau-Them F, Bruel AL, Faivre L, Demurger F, Pasquier L, Odent S, Fradin M, Lavillaureix A. | 02/5/2022 |
| Expanding the clinical phenotype of the ultra-rare Skraban-Deardorff syndrome: Two novel individuals with WDR26 loss-of-function variants and a literature review. | Expanding the clinical phenotype of the ultra-rare Skraban-Deardorff syndrome: Two novel individuals with WDR26 loss-of-function variants and a literature review.
Pavinato L, Trajkova S, Grosso E, Giorgio E, Bruselles A, Radio FC, Pippucci T, Dimartino P, Tartaglia M, Petlichkovski A, De Rubeis S, Buxbaum J, Ferrero GB, Keller R, Brusco A. | 09/4/2021 |
| GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Sherpa D, Chrustowicz J, Qiao S, Langlois CR, Hehl LA, Gottemukkala KV, Hansen FM, Karayel O, von Gronau S, Prabu JR, Mann M, Alpi AF, Schulman BA., Free PMC Article | 06/26/2021 |
| WD40 Repeat Protein 26 Negatively Regulates Formyl Peptide Receptor-1 Mediated Wound Healing in Intestinal Epithelial Cells. | WD40 Repeat Protein 26 Negatively Regulates Formyl Peptide Receptor-1 Mediated Wound Healing in Intestinal Epithelial Cells.
Hasegawa M, Parkos CA, Nusrat A., Free PMC Article | 11/21/2020 |
| haploinsufficiency of WDR26 contributes to the pathology of 1q41q42 microdeletion syndrome. | WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features.
Skraban CM, Wells CF, Markose P, Cho MT, Nesbitt AI, Au PYB, Begtrup A, Bernat JA, Bird LM, Cao K, de Brouwer APM, Denenberg EH, Douglas G, Gibson KM, Grand K, Goldenberg A, Innes AM, Juusola J, Kempers M, Kinning E, Markie DM, Owens MM, Payne K, Person R, Pfundt R, Stocco A, Turner CLS, Verbeek NE, Walsh LE, Warner TC, Wheeler PG, Wieczorek D, Wilkens AB, Zonneveld-Huijssoon E, Deciphering Developmental Disorders Study, Kleefstra T, Robertson SP, Santani A, van Gassen KLI, Deardorff MA., Free PMC Article | 08/5/2017 |
| It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism. | Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.
Castro-Castro A, Muriel O, Del Pozo MA, Bustelo XR., Free PMC Article | 06/24/2017 |
| WDR26 affected beta-catenin levels. WDR26/Axin binding is involved in the ubiquitination of beta-catenin. | WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.
Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H., Free PMC Article | 05/7/2017 |
| WDR26 serves as a scaffold that fosters assembly of a specific signaling complex consisting of Gbetagamma, PI3Kbeta and AKT2 in breast cancer. | Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion.
Ye Y, Tang X, Sun Z, Chen S., Free PMC Article | 02/18/2017 |
| The WDR26 gene was differentially methylated in monozygotic twins discordant for depressive disorder. | Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins.
Córdova-Palomera A, Fatjó-Vilas M, Gastó C, Navarro V, Krebs MO, Fañanás L., Free PMC Article | 01/16/2016 |
| WDR26 functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes. | WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.
Sun Z, Smrcka AV, Chen S., Free PMC Article | 08/31/2013 |
| WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration | The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
Sun Z, Tang X, Lin F, Chen S., Free PMC Article | 02/25/2012 |
| these data suggest that MIP2 may participate in the progression of cell proliferation in H9c2 cells. | Overexpression of MIP2, a novel WD-repeat protein, promotes proliferation of H9c2 cells.
Wei X, Song L, Jiang L, Wang G, Luo X, Zhang B, Xiao X. | 05/3/2010 |
| The results of this study indicated that WDR26 was up-regulated by oxidative stress and played a key role in H2O2-induced SH-SY5Y cell death, which may be mediated by the down-regulation of AP-1 transcriptional activity. | A novel WD-40 repeat protein WDR26 suppresses H2O2-induced cell death in neural cells.
Zhao J, Liu Y, Wei X, Yuan C, Yuan X, Xiao X. | 01/21/2010 |
| WDR26 may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction. | WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway.
Zhu Y, Wang Y, Xia C, Li D, Li Y, Zeng W, Yuan W, Liu H, Zhu C, Wu X, Liu M. | 01/21/2010 |