| CST-polymerase alpha-primase solves a second telomere end-replication problem. | CST-polymerase α-primase solves a second telomere end-replication problem.
Takai H, Aria V, Borges P, Yeeles JTP, de Lange T., Free PMC Article | 04/3/2024 |
| A novel mutation of CTC1 leads to telomere shortening in a chinese family with interstitial lung disease. | A novel mutation of CTC1 leads to telomere shortening in a chinese family with interstitial lung disease.
Liu L, Luo H, Sheng Y, Kang X, Peng H, Luo H, Fan LL., Free PMC Article | 03/14/2024 |
| CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension. | CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.
Wang H, Ma T, Zhang X, Chen W, Lan Y, Kuang G, Hsu SJ, He Z, Chen Y, Stewart J, Bhattacharjee A, Luo Z, Price C, Feng X., Free PMC Article | 06/13/2023 |
| Reconstitution of a telomeric replicon organized by CST. | Reconstitution of a telomeric replicon organized by CST.
Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR., Free PMC Article | 09/3/2022 |
| Structures of the human CST-Polalpha-primase complex bound to telomere templates. | Structures of the human CST-Polα-primase complex bound to telomere templates.
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ., Free PMC Article | 09/3/2022 |
| Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology. | Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology.
Dos Santos GA, Viana NI, Pimenta R, de Camargo JA, Guimaraes VR, Romão P, Candido P, Ghazarian V, Reis ST, Leite KRM, Srougi M. | 05/7/2022 |
| Primary Ovarian Failure in Addition to Classical Clinical Features of Coats Plus Syndrome in a Female Carrying 2 Truncating Variants of CTC1. | Primary Ovarian Failure in Addition to Classical Clinical Features of Coats Plus Syndrome in a Female Carrying 2 Truncating Variants of CTC1.
Riquelme J, Takada S, van Dijk T, Peña F, Boogaard MW, van Duyvenvoorde HA, Pico-Knijnenburg I, Wit JM, van der Burg M, Mericq V, Losekoot M. | 04/9/2022 |
| The DNA-binding protein CST associates with the cohesin complex and promotes chromosome cohesion. | The DNA-binding protein CST associates with the cohesin complex and promotes chromosome cohesion.
Schuck PL, Ball LE, Stewart JA., Free PMC Article | 12/11/2021 |
| Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress. | Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress.
Ackerson SM, Gable CI, Stewart JA., Free PMC Article | 12/4/2021 |
| Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1. | Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1.
Choudhury A, Mohammad T, Samarth N, Hussain A, Rehman MT, Islam A, Alajmi MF, Singh S, Hassan MI., Free PMC Article | 11/13/2021 |
| Ophthalmic findings and a novel CTC1 gene mutation in coats plus syndrome: a case report. | Ophthalmic findings and a novel CTC1 gene mutation in coats plus syndrome: a case report.
Liang T, Zhang X, Xu Y, Zhao P. | 09/4/2021 |
| CST in maintaining genome stability: Beyond telomeres. | CST in maintaining genome stability: Beyond telomeres.
Lyu X, Sang PB, Chai W., Free PMC Article | 08/21/2021 |
| Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. | Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA.
Lyu X, Lei KH, Biak Sang P, Shiva O, Chastain M, Chi P, Chai W., Free PMC Article | 04/24/2021 |
| CST functions in two distinct aspects of genome-wide DNA replication, namely, origin licensing and replisome assembly. CST interacts with additional replisome components, MCM and AND-1. | Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association.
Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA., Free PMC Article | 02/29/2020 |
| Impaired interaction between CTC1(L1142H) :STN1 and DNA Pol-alpha results in increased telomerase recruitment to telomeres and further telomere elongation, revealing that C:S binding to DNA Pol-alpha is required to fully repress telomerase activity. | CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.
Gu P, Jia S, Takasugi T, Smith E, Nandakumar J, Hendrickson E, Chang S., Free PMC Article | 10/12/2019 |
| Results show that disease-causing CTC1 mutations induce spontaneous chromosome breakage and severe chromosome fragmentation that are further elevated by replication stress, leading to global genome instabilities. | Pathogenic CTC1 mutations cause global genome instabilities under replication stress.
Wang Y, Chai W., Free PMC Article | 08/10/2019 |
| Findings indicate the OB-fold domain contributes to efficient CST telomere replication complex component 1 (Ctc1) telomere localization and chromosome end maintenance. | Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.
Shastrula PK, Rice CT, Wang Z, Lieberman PM, Skordalakes E., Free PMC Article | 07/27/2019 |
| Studies indicate telomere-binding proteins CTC1-STN1-TEN1 (CST) dysfunction and mutation is associated with several genetic diseases and cancers [Review]. | Emerging roles of CST in maintaining genome stability and human disease.
Stewart JA, Wang Y, Ackerson SM, Schuck PL., Free PMC Article | 02/2/2019 |
| CTC1 pathogenic variants can present with unusual manifestations of progeria accompanied with recurrent bone fractures. | CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures.
Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J., Free PMC Article | 01/26/2019 |
| CTC1-STN1 terminates TERT while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. | CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.
Feng X, Hsu SJ, Bhattacharjee A, Wang Y, Diao J, Price CM., Free PMC Article | 12/22/2018 |
| CTC1/STN1/TEN1 (CST) deficiency diminishes HU-induced RAD51 foci formation. | Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.
Chastain M, Zhou Q, Shiva O, Fadri-Moskwik M, Whitmore L, Jia P, Dai X, Huang C, Ye P, Chai W., Free PMC Article | 11/18/2017 |
| The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells. | The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.
Huang C, Jia P, Chastain M, Shiva O, Chai W., Free PMC Article | 10/7/2017 |
| TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance. | CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.
Feng X, Hsu SJ, Kasbek C, Chaiken M, Price CM., Free PMC Article | 09/16/2017 |
| HBV DNAPTP1 downregulated the expression of SWI5 and CTC1 at translation level. | Downregulation of SWI5 and CTC1 genes: hepatitis B virus DNA polymerase transactivated protein 1-mediated inhibition of DNA repair.
Yao XK, Pan ZP, Li Y, Lun YZ, Chi Q, Jiang SJ, Wang F, Sui W. | 09/24/2016 |
| Coats plus syndrome also known as cerebroretinal microangiopathy with calcifications and cysts, is an autosomal recessive pleomorphic disorder caused by the CTS telomere maintenance complex component 1 gene. | Genetics and molecular biology of brain calcification.
Deng H, Zheng W, Jankovic J. | 03/12/2016 |