| Molecular crosstalk between CUEDC2 and ERalpha influences the clinical outcome by regulating mitosis in breast cancer. | Molecular crosstalk between CUEDC2 and ERα influences the clinical outcome by regulating mitosis in breast cancer.
Roy S, Saha S, Dhar D, Chakraborty P, Singha Roy K, Mukherjee C, Gupta A, Bhattacharyya S, Roy A, Sengupta S, Roychoudhury S, Nath S. | 11/19/2022 |
| Kawasaki disease: SOCS2-AS1/miR-324-5p/CUEDC2 axis regulates the progression of human umbilical vein endothelial cells. | Kawasaki disease: SOCS2-AS1/miR-324-5p/CUEDC2 axis regulates the progression of human umbilical vein endothelial cells.
Zhao J, Chen D. | 10/8/2022 |
| MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. | MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness.
Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. | 02/19/2022 |
| Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance. | Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.
Xu S, Huang S, Li D, Zou Q, Yuan Y, Yang Z. | 10/16/2021 |
| Expression of CUE domain containing 2 protein in serous ovarian cancer tissue: predicting disease-free and overall survival of patients. | Expression of CUE domain containing 2 protein in serous ovarian cancer tissue: predicting disease-free and overall survival of patients.
Lingyun H, Ailing L, Yali L, Yanqin Y, Jing N., Free PMC Article | 06/19/2021 |
| LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. | LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway.
Mu M, Niu W, Zhang X, Hu S, Niu C., Free PMC Article | 12/12/2020 |
| CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia | CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.
Wu QY, Zhu YY, Liu Y, Wei F, Tong YX, Cao J, Zhou P, Niu MS, Li ZY, Zeng LY, Li F, Xu KL., Free PMC Article | 11/30/2019 |
| review of CUEDC2 expression in various tumors, and discussion of several fundamental signaling pathways that are impacted by CUEDC2 [review] | CUEDC2: multifunctional roles in carcinogenesis.
Xiao JB, Leng AM, Zhang YQ, Wen Z, He J, Ye GN. | 08/10/2019 |
| High Expression of CUEDC2 is associated with invasion and metastasis in colorectal cancer. | Expression of CUEDC2 in colorectal cancer with different invasion and migration abilities.
Hu S, Hu Z, Li S, He C, Wu Y, Teng D, Yan Y, Li H, Xing X, Zou G, Li Y, Yang Y, Wang Y, Du X., Free PMC Article | 06/15/2019 |
| the present study demonstrated that CUEDC2 downregulation prevented DOXinduced cardiotoxicity in H9c2 cells. Therefore, CUEDC2 may be a promising target for the prevention of DOXinduced cardiotoxicity. | Downregulation of CUEDC2 prevents doxorubicin‑induced cardiotoxicity in H9c2 cells.
Zhang X, Li J, Cheng Y, Yi J, Liu X, Cheng W., Free PMC Article | 10/20/2018 |
| MicroRNA hsa-miR-324-5p suppresses H5N1 virus replication by targeting the viral PB1 and host CUEDC2. | MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2.
Kumar A, Kumar A, Ingle H, Kumar S, Mishra R, Verma MK, Biswas D, Kumar NS, Mishra A, Raut AA, Takaoka A, Kumar H., Free PMC Article | 09/22/2018 |
| Low CUEDC2 expression is associated with glioma. | CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway.
Li F, Tang C, Jin D, Guan L, Wu Y, Liu X, Wu X, Wu QY, Gao D., Free PMC Article | 07/21/2018 |
| findings show a correlation between the aberrant expression of CUEDC2, and GLUT3 and LDHA in clinical hepatocellular carcinoma samples, further demonstrating a link between CUEDC2 and the Warburg effect during cancer development | CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P., Free PMC Article | 01/27/2018 |
| Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome. | CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.
Sun L, Bai L, Lin G, Wang R, Liu Y, Cai J, Guo Y, Zhu Z, Xie C., Free PMC Article | 07/16/2016 |
| CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis. | Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.
Chen Y, Wang SX, Mu R, Luo X, Liu ZS, Liang B, Zhuo HL, Hao XP, Wang Q, Fang DF, Bai ZF, Wang QY, Wang HM, Jin BF, Gong WL, Zhou T, Zhang XM, Xia Q, Li T. | 04/18/2015 |
| High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment. | CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
Zhang H, Chang G, Wang J, Lin Y, Ma L, Pang T. | 01/11/2014 |
| In response to UV irradiation, CUEDC2 undergoes ERK1/2-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC/C(Cdh1)-mediated cyclin A destruction, cyclin-dependent kinase 2 inactivation, and G1 arrest. | Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation.
Zhang WN, Zhou J, Zhou T, Li AL, Wang N, Xu JJ, Chang Y, Man JH, Pan X, Li T, Li WH, Mu R, Liang B, Chen L, Jin BF, Xia Q, Gong WL, Zhang XM, Wang L, Li HY., Free PMC Article | 09/28/2013 |
| a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway | CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.
Zhang WN, Wang L, Wang Q, Luo X, Fang DF, Chen Y, Pan X, Man JH, Xia Q, Jin BF, Li WH, Li T, Liang B, Chen L, Gong WL, Yu M, Li AL, Zhou T, Li HY., Free PMC Article | 05/12/2012 |
| CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 during mitosis. | Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.
Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY, Zhang XM. | 10/1/2011 |
| key factor in endocrine resistance in breast cancer | Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.
Pan X, Zhou T, Tai YH, Wang C, Zhao J, Cao Y, Chen Y, Zhang PJ, Yu M, Zhen C, Mu R, Bai ZF, Li HY, Li AL, Liang B, Jian Z, Zhang WN, Man JH, Gao YF, Gong WL, Wei LX, Zhang XM. | 08/20/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| These results identify a key post-translational mechanism that controls progesterone receptor protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation. | CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.
Zhang PJ, Zhao J, Li HY, Man JH, He K, Zhou T, Pan X, Li AL, Gong WL, Jin BF, Xia Q, Yu M, Shen BF, Zhang XM., Free PMC Article | 01/21/2010 |