| Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells. | Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells.
Güleç Taşkıran AE, Hüsnügil HH, Soltani ZE, Oral G, Menemenli NS, Hampel C, Huebner K, Erlenbach-Wuensch K, Sheraj I, Schneider-Stock R, Akyol A, Liv N, Banerjee S. | 10/1/2024 |
| Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients. | Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients.
Tahoun M, Sadaka AS. | 10/1/2024 |
| Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition. | Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition.
Talaia G, Bentley-DeSousa A, Ferguson SM., Free PMC Article | 09/24/2024 |
| A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy. | A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy.
Tudorica DA, Basak B, Puerta Cordova AS, Khuu G, Rose K, Lazarou M, Holzbaur ELF, Hurley JH., Free PMC Article | 05/23/2024 |
| Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. | Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.
Gaur P, Rajendran Y, Srivastava B, Markandey M, Fishbain-Yoskovitz V, Mohapatra G, Suhail A, Chaudhary S, Tyagi S, Yadav SC, Pandey AK, Merbl Y, Bajaj A, Ahuja V, Srikanth C., Free PMC Article | 04/24/2024 |
| [Silencing SIRT1 reduces 5-fluorouracil resistance of cholangiocarcinoma cells by inhibiting the FOXO1/Rab7 autophagy pathway]. | [Silencing SIRT1 reduces 5-fluorouracil resistance of cholangiocarcinoma cells by inhibiting the FOXO1/Rab7 autophagy pathway].
Xin C, Wang X, Li X, Chen Y, Wang X, Ning J, Yang S, Wang Z., Free PMC Article | 05/5/2023 |
| Lipophagy-related gene RAB7A is involved in immune regulation and malignant progression in hepatocellular carcinoma. | Lipophagy-related gene RAB7A is involved in immune regulation and malignant progression in hepatocellular carcinoma.
Liu Y, Ma J, Wang X, Liu P, Cai C, Han Y, Zeng S, Feng Z, Shen H. | 04/21/2023 |
| Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167. | Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167.
Ghilarducci K, Cabana VC, Harake A, Cappadocia L, Lussier MP., Free PMC Article | 08/6/2022 |
| Polarized alpha-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers. | Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.
Alam P, Holst MR, Lauritsen L, Nielsen J, Nielsen SSE, Jensen PH, Brewer JR, Otzen DE, Nielsen MS., Free PMC Article | 06/18/2022 |
| Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. | Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D, Fu M, Ma L, Song Y, Zhang W, Zhan Q., Free PMC Article | 03/12/2022 |
| Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis. | Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Yang Y, Wang J, Zhang Y, Hu X, Li L, Chen P., Free PMC Article | 01/29/2022 |
| Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond. | Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond.
Borchers AC, Langemeyer L, Ungermann C., Free PMC Article | 11/13/2021 |
| TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7. | TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
Hu J, Ding X, Tian S, Chu Y, Liu Z, Li Y, Li X, Wang G, Wang L, Wang Z., Free PMC Article | 10/16/2021 |
| Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. | Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression.
Yeh YC, Lin YP, Kramer H, Parekh AB., Free PMC Article | 08/14/2021 |
| Post-translational modifications: How to modulate Rab7 functions. | Post-translational modifications: How to modulate Rab7 functions.
Modica G, Lefrancois S., Free PMC Article | 07/17/2021 |
| TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. | TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
Xie J, Heim EN, Crite M, DiMaio D., Free PMC Article | 05/22/2021 |
| LRP6 regulates Rab7-mediated autophagy through the Wnt/beta-catenin pathway to modulate trophoblast cell migration and invasion. | LRP6 regulates Rab7-mediated autophagy through the Wnt/β-catenin pathway to modulate trophoblast cell migration and invasion.
Li L, Peng W, Zhou Q, Wan JP, Wang XT, Qi HB. | 05/1/2021 |
| Rab7 Is Associated with Poor Prognosis of Gastric Cancer and Promotes Proliferation, Invasion, and Migration of Gastric Cancer Cells. | Rab7 Is Associated with Poor Prognosis of Gastric Cancer and Promotes Proliferation, Invasion, and Migration of Gastric Cancer Cells.
Liu H, Xu J, Yao Q, Zhang Z, Guo Q, Lin J., Free PMC Article | 05/1/2021 |
| IKKbeta activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. | IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Peng X, Yang L, Ma Y, Li X, Yang S, Li Y, Wu B, Tang S, Zhang F, Zhang B, Liu J, Li H. | 04/17/2021 |
| Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation. | Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation.
Saveri P, De Luca M, Nisi V, Pisciotta C, Romano R, Piscosquito G, Reilly MM, Polke JM, Cavallaro T, Fabrizi GM, Fossa P, Cichero E, Lombardi R, Lauria G, Magri S, Taroni F, Pareyson D, Bucci C., Free PMC Article | 02/27/2021 |
| Alteration of the late endocytic pathway in Charcot-Marie-Tooth type 2B disease. | Alteration of the late endocytic pathway in Charcot-Marie-Tooth type 2B disease.
Romano R, Rivellini C, De Luca M, Tonlorenzi R, Beli R, Manganelli F, Nolano M, Santoro L, Eskelinen EL, Previtali SC, Bucci C., Free PMC Article | 02/20/2021 |
| A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export. | A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.
van den Boomen DJH, Sienkiewicz A, Berlin I, Jongsma MLM, van Elsland DM, Luzio JP, Neefjes JJC, Lehner PJ., Free PMC Article | 11/28/2020 |
| Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. | Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH., Free PMC Article | 09/19/2020 |
| Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting Rab7 inactivation via TBC1D15, a Rab7-GAP. | Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells.
Meneses-Salas E, García-Melero A, Kanerva K, Blanco-Muñoz P, Morales-Paytuvi F, Bonjoch J, Casas J, Egert A, Beevi SS, Jose J, Llorente-Cortés V, Rye KA, Heeren J, Lu A, Pol A, Tebar F, Ikonen E, Grewal T, Enrich C, Rentero C., Free PMC Article | 07/11/2020 |
| GTP-bound Rab7 is phosphorylated on S72 by leucine-rich repeat kinase 1 at the endosomal membrane resulting in recruitment of the dynein-dynactin complex to Rab7-positive vesicles. This, in turn, facilitates the dynein-driven transport of EGFR-containing endosomes toward the perinuclear region. | LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP.
Hanafusa H, Yagi T, Ikeda H, Hisamoto N, Nishioka T, Kaibuchi K, Shirakabe K, Matsumoto K. | 07/4/2020 |