| RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer. | RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer.
Di Donato M, Di Zazzo E, Salvati A, Sorrentino C, Giurato G, Fiore D, Proto MC, Rienzo M, Casamassimi A, Gazzerro P, Bifulco M, Castoria G, Weisz A, Nassa G, Abbondanza C., Free PMC Article | 10/30/2023 |
| Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation. | Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation.
Di Zazzo E, Rienzo M, Casamassimi A, De Rosa C, Medici N, Gazzerro P, Bifulco M, Abbondanza C., Free PMC Article | 03/28/2023 |
| PRDM2 negatively regulated the expression of c-Myc in somatotroph adenomas, and testified the synergism between PRDM2 gene therapy and c-Myc inhibitor in vitro experiment | The absence of PRDM2 involved the tumorigenesis of somatotroph adenomas through regulating c-Myc.
Wei D, Yiyuan C, Qian L, Jianhua L, Yazhuo Z, Hua G. | 04/11/2020 |
| The authors have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein. | Repression of Akt3 gene transcription by the tumor suppressor RIZ1.
Liu Q, Qu X, Xie X, He P, Huang S., Free PMC Article | 12/22/2018 |
| Promoter hypermethylation may play an important role in the epigenetic silencing of RIZ1 expression in human glioma tissues and glioblastoma cell lines. | Methylation Status of the RIZ1 Gene Promoter in Human Glioma Tissues and Cell Lines.
Zhang C, Meng W, Wang J, Lu Y, Hu G, Hu L, Ma J. | 04/14/2018 |
| the Pro704 p-/- allele of RIZ is significantly more common in CML patients with Loss of hematological response than good responders (p = .001). We showed that LOH p-/- homozygosity of RIZ1 was common event in BC than proline p+/+ homozygosity and proline p+/+ homozygosity more common feature in CP phase CML. | A deletion polymorphism in the RIZ gene is associated with increased progression of imatinib treated chronic myeloid leukemia patients.
Mir R, Najar IA, Guru S, Javaid J, Yadav P, Masroor M, Zuberi M, Farooq S, Bhat M, Gupta N, Ray PC, Saxena A. | 01/13/2018 |
| Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications | RIZ1 and histone methylation status in pituitary adenomas.
Xue Y, Chen R, Du W, Yang F, Wei X. | 07/29/2017 |
| RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas. | RIZ1: a potential tumor suppressor in glioma.
Zhang C, Zhu Q, He H, Jiang L, Qiang Q, Hu L, Hu G, Jiang Y, Ding X, Lu Y., Free PMC Article | 08/13/2016 |
| Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma. | Aberrant Methylation of the 1p36 Tumor Suppressor Gene RIZ1 in Renal Cell Carcinoma.
Ge P, Yu X, Wang ZC, Lin J. | 02/20/2016 |
| PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas. | Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.
Gao H, Wang F, Lan X, Li C, Feng J, Bai J, Cao L, Gui S, Hong L, Zhang Y., Free PMC Article | 01/30/2016 |
| Results suggest that high expression of SMYD3 is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 and RIZ1. | Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma.
Dong SW, Zhang H, Wang BL, Sun P, Wang YG, Zhang P. | 11/7/2015 |
| PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. | Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells.
Tan SX, Hu RC, Liu JJ, Tan YL, Liu WE., Free PMC Article | 02/28/2015 |
| The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1. | Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma by RIZ1 upregulation.
Dong SW, Li D, Xu C, Sun P, Wang YG, Zhang P., Free PMC Article | 03/15/2014 |
| RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas. | Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) dysregulation in human malignant meningiomas.
Liu ZY, Wang JY, Liu HH, Ma XM, Wang CL, Zhang XP, Tao YQ, Lu YC, Liao JC, Hu GH. | 08/3/2013 |
| Reduction of RIZ1 expression aggravates the progression of liver fluke-related cholangiocarcinoma | Contribution of RIZ1 to regulation of proliferation and migration of a liver fluke-related cholangiocarcinoma cell.
Khaenam P, Niibori A, Okada S, Jearanaikoon P, Araki N, Limpaiboon T. | 04/20/2013 |
| Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype | Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype.
Shimura H, Mori N, Wang YH, Okada M, Motoji T. | 12/22/2012 |
| Data suggest that promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human esophageal squamous cell carcinoma. | Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma.
Dong SW, Zhang P, Liu YM, Cui YT, Wang S, Liang SJ, He Z, Sun P, Wang YG., Free PMC Article | 04/28/2012 |
| Acting as a negative regulator of RIZ1 function, PRFM2 mediates effect of cell proliferation by estrogen via regulation of cell survival and differentiating gene expression. | Identification of a functional estrogen-responsive enhancer element in the promoter 2 of PRDM2 gene in breast cancer cell lines.
Abbondanza C, De Rosa C, D'Arcangelo A, Pacifico M, Spizuoco C, Piluso G, Di Zazzo E, Gazzerro P, Medici N, Moncharmont B, Puca GA. | 04/28/2012 |
| RIZ1 may be a potential tumor suppressor in human esophageal squamous cell cancer. | Decreased expression of retinoblastoma protein-interacting zinc-finger gene 1 in human esophageal squamous cell cancer by DNA methylation.
Dong SW, Cui YT, Zhong RR, Liang DC, Liu YM, Wang YG, He Z, Wang S, Liang SJ, Zhang P. | 03/17/2012 |
| RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity. | Anticancer activity of the PR domain of tumor suppressor RIZ1.
Sun W, Qiao L, Liu Q, Chen L, Ling B, Sammynaiken R, Yang J., Free PMC Article | 06/25/2011 |
| Results suggest that the RIZ1 gene is inactivated in MDS and AML in part by methylation, whereas another mechanism should be involved in others. | Aberrant methylation of the RIZ1 gene in myelodysplastic syndrome and acute myeloid leukemia.
Mori N, Yoshinaga K, Tomita K, Ohwashi M, Kondoh T, Shimura H, Wang YH, Shiseki M, Okada M, Motoji T. | 06/18/2011 |
| promoter methylation and H3K9 modifications work together to silence the RIZ1 gene in hepatocellular carcinoma (HCC). | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications.
Zhang C, Li H, Wang Y, Liu W, Zhang Q, Zhang T, Zhang X, Han B, Zhou G. | 02/5/2011 |
| RIZ1 promoter methylation is not a common event in neuroblastoma. | Suppression of RIZ in biologically unfavourable neuroblastomas.
Geli J, Kiss N, Kogner P, Larsson C. | 01/29/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators. | 12/5/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruïne AP, Goldbohm RA, van den Brandt PA, van Engeland M, Weijenberg MP., Free PMC Article | 12/5/2010 |