| An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain. | An orally available Ca(v)2.2 calcium channel inhibitor for the treatment of neuropathic pain.
Kutzsche J, Guzman GA, Willuweit A, Kletke O, Wollert E, Gering I, Jürgens D, Breitkreutz J, Stark H, Beck-Sickinger AG, Klöcker N, Hidalgo P, Willbold D. | 05/13/2024 |
| Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization. | Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization.
Xue Y, Li M, Hu J, Song Y, Guo W, Miao C, Ge D, Hou Y, Wang X, Huang X, Liu T, Zhang X, Huang Q., Free PMC Article | 10/8/2022 |
| High expression of N-type calcium channel indicates a favorable prognosis in gliomas. | High expression of N-type calcium channel indicates a favorable prognosis in gliomas.
Li G, Roy B, Huang X, Mu Y, Yuan J, Xia Y, Song Y, Peng Z., Free PMC Article | 07/23/2022 |
| Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2. | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca(V)2.2.
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y. | 02/19/2022 |
| CACNA1B facilitates breast cancer cell growth and migration by regulating cyclin D1 and EMT: the implication of CACNA1B in breast cancer. | CACNA1B facilitates breast cancer cell growth and migration by regulating cyclin D1 and EMT: the implication of CACNA1B in breast cancer.
Jin YM, Ye Y, Bao WQ, Tong Y, Ni SB, Liu JP, Zhao B. | 02/19/2022 |
| CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways. | Ca(V)2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways.
Silveirinha VC, Lin H, Tanifuji S, Mochida S, Cottrell GS, Cimarosti H, Stephens GJ. | 09/25/2021 |
| Structure of human Cav2.2 channel blocked by the painkiller ziconotide. | Structure of human Ca(v)2.2 channel blocked by the painkiller ziconotide.
Gao S, Yao X, Yan N., Free PMC Article | 08/21/2021 |
| CACNA1B gene variants in adult-onset isolated focal dystonia. | CACNA1B gene variants in adult-onset isolated focal dystonia.
Cocoș R, Raicu F, Băjenaru OL, Olaru I, Dumitrescu L, Popescu BO., Free PMC Article | 07/24/2021 |
| Bi-allelic Loss-of-Function CACNA1B Mutations are associated with Progressive Epilepsy-Dyskinesia. | Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G, Deciphering Developmental Disorders Study, UK10K Consortium, NIHR BioResource, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA., Free PMC Article | 02/8/2020 |
| Cav2.2 alpha1 subunit alone could form a complex with the AMPAR in heterologous cells. The cell-surface AMPAR was increased by co-expression of Cav2.2 alpha1 subunit. | Neuronal calcium channel α(1) subunit interacts with AMPA receptor, increasing its cell surface localisation.
Seo BA, Lee JH, Kim HM, Kang MG. | 05/5/2018 |
| CACNA1B protein expressions in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. CACNA1B mRNA and protein expression levels were higher in NSCLC tumorous tissues than in nontumorous tissues. | CACNA1B (Ca(v)2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Zhou X, Wang W, Zhang S, Wang X, Tang Z, Gu J, Li J, Huang J., Free PMC Article | 02/18/2017 |
| These results do not support a causal association between the CACNA1B c.4166G>A; (p.R1389H) variant and M-D. | The CACNA1B R1389H variant is not associated with myoclonus-dystonia in a large European multicentric cohort.
Mencacci NE, R'bibo L, Bandres-Ciga S, Carecchio M, Zorzi G, Nardocci N, Garavaglia B, Batla A, Bhatia KP, Pittman AM, Hardy J, Weissbach A, Klein C, Gasser T, Lohmann E, Wood NW., Free PMC Article | 06/4/2016 |
| the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in Cav1.2 and Cav2.1. | Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.
Zhou MH, Bavencoffe A, Pan HL., Free PMC Article | 04/23/2016 |
| AP-1 binding motifs, present only in exon 37a, enhance intracellular trafficking of exon 37a-containing Ca(V)2.2 to the axons and plasma membrane of rat dorsal root ganglia neurons | Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs.
Macabuag N, Dolphin AC., Free PMC Article | 02/6/2016 |
| CACNA1B mutation is linked to unique myoclonus-dystonia syndrome. | CACNA1B mutation is linked to unique myoclonus-dystonia syndrome.
Groen JL, Andrade A, Ritz K, Jalalzadeh H, Haagmans M, Bradley TE, Jongejan A, Verbeek DS, Nürnberg P, Denome S, Hennekam RC, Lipscombe D, Baas F, Tijssen MA., Free PMC Article | 09/26/2015 |
| The first disease connection for Cav2.2 channels [review] | The first disease connection for Cav2.2 channels.
Weiss N. | 09/12/2015 |
| The interaction between LC1 and the N-type channel (CaV2.2 channel) was demonstrated. | CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation.
Gandini MA, Henríquez DR, Grimaldo L, Sandoval A, Altier C, Zamponi GW, Felix R, González-Billault C. | 06/27/2015 |
| with membrane-localized CaV beta subunits, CaV2.2 channels are subject to Gbetagamma-mediated voltage-dependent inhibition, whereas cytosol-localized beta subunits confer more effective PIP2-mediated voltage-independent regulation | Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized β subunit.
Keum D, Baek C, Kim DI, Kweon HJ, Suh BC., Free PMC Article | 06/6/2015 |
| Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. | γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins.
Cuny H, de Faoite A, Huynh TG, Yasuda T, Berecki G, Adams DJ., Free PMC Article | 10/13/2012 |
| new mechanistic perspectives, and reveal unexpected variations in determinants, underlying inhibition of Ca(V)1.2/Ca(V)2.2 channels by distinct RGK GTPases. | Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.
Yang T, Puckerin A, Colecraft HM., Free PMC Article | 09/22/2012 |
| Ca(2+) exits the channel through the Cav2.2. | Nanodomain Ca²⁺ of Ca²⁺ channels detected by a tethered genetically encoded Ca²⁺ sensor.
Tay LH, Dick IE, Yang W, Mank M, Griesbeck O, Yue DT., Free PMC Article | 07/28/2012 |
| polymorphisms and haplotypes in the human CACNA1B gene show significant differences between cerebral infarction and control patients | The haplotype of the CACNA1B gene associated with cerebral infarction in a Japanese population.
Yamaguchi M, Nakayama T, Fu Z, Sato N, Soma M, Morita A, Hinohara S, Doba N, Mizutani T. | 05/7/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The orientation of the Ca(v)beta subunit relative to the alpha(1)2.2 subunit is critical, and suggests additional points of contact between these subunits are required for Ca(v)beta to regulate channel activity. | Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.
Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesCase-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.
Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM. Strong synaptic transmission impact by copy number variations in schizophrenia.
Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PM, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, Otieno FG, Davidson M, Weiser M, Reichenberg A, Davis KL, Friedman JI, Cappola TP, Margulies KB, Rader DJ, Grant SF, Buxbaum JD, Gur RE, Hakonarson H. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Wellcome Trust Case Control Consortium, Owen MJ, O'Donovan MC. | 01/11/2009 |