| Genetic polymorphism of WNT9A is functionally associated with thumb osteoarthritis in the Chinese population. | Genetic polymorphism of WNT9A is functionally associated with thumb osteoarthritis in the Chinese population.
Dai J, Jiang H, Cheng Z, Li Y, Yang Z, Cheng C, Tang X. | 02/8/2024 |
| WNT9A Affects Late-Onset Acute Respiratory Distress Syndrome and 28-Day Survival: Evidence from a Three-Step Multiomics Study. | WNT9A Affects Late-Onset Acute Respiratory Distress Syndrome and 28-Day Survival: Evidence from a Three-Step Multiomics Study.
Chen J, Tang J, Nie M, Li Y, Wurfel MM, Meyer NJ, Wei Y, Zhao Y, Frank AJ, Thompson BT, Christiani DC, Chen F, Zhang R., Free PMC Article | 08/2/2023 |
| Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene. | Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.
Boer CG, Yau MS, Rice SJ, Coutinho de Almeida R, Cheung K, Styrkarsdottir U, Southam L, Broer L, Wilkinson JM, Uitterlinden AG, Zeggini E, Felson D, Loughlin J, Young M, Capellini TD, Meulenbelt I, van Meurs JB., Free PMC Article | 07/2/2022 |
| Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. | Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice.
Teufel S, Köckemann P, Fabritius C, Wolff LI, Bertrand J, Pap T, Hartmann C., Free PMC Article | 10/16/2021 |
| Compared with normal tubular cells, tubular cells of humans with a variety of nephropathies expressed high levels of Wnt9a that colocalized with p16(INK4A). Wnt9a expression level correlated with the extent of renal fibrosis, decline of eGFR, and expression of p16(INK4A).In a proximal tubular epithelial cell line and primary renal tubular cells, Wnt9a upregulated p16(INK4A). | Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells.
Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu J, Zhang Y, Li H, Liu Y, Hou FF, Zhou L., Free PMC Article | 09/21/2019 |
| We demonstrate that the epidermal growth factor receptor (EGFR) is required as a cofactor for Wnt9a-Fzd9b signalling. EGFR-mediated phosphorylation of one tyrosine residue on the Fzd9b intracellular tail in response to Wnt9a promotes internalization of the Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction | EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells.
Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D., Free PMC Article | 07/13/2019 |
| This manipulation increased one type of sensory hair cell (tall HCs) at the expense of another (short HCs) that is usually located furthest from the Wnt9a source. The extraneous tall HCs that replaced short HCs showed some physiological properties and neuronal connections consistent with a fate switch. | Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea.
Munnamalai V, Sienknecht UJ, Duncan RK, Scott MK, Thawani A, Fantetti KN, Atallah NM, Biesemeier DJ, Song KH, Luethy K, Traub E, Fekete DM., Free PMC Article | 09/30/2017 |
| Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency. | In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.
Rudy SF, Brenner JC, Harris JL, Liu J, Che J, Scott MV, Owen JH, Komarck CM, Graham MP, Bellile EL, Bradford CR, Prince ME, Carey TE., Free PMC Article | 10/22/2016 |
| expression is enhanced in idiopathic carpal tunnel syndrome | Enhanced expression of Wnt9a in the flexor tenosynovium in idiopathic carpal tunnel syndrome.
Yamanaka Y, Menuki K, Zenke Y, Hirasawa H, Sakai A. | 11/28/2015 |
| Silencing Wnt9A increased the expression of CHST11 in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A siRNA and exogenous BMP4 on the CHST11 promoter | Regulation of chondroitin-4-sulfotransferase (CHST11) expression by opposing effects of arylsulfatase B on BMP4 and Wnt9A.
Bhattacharyya S, Feferman L, Tobacman JK., Free PMC Article | 08/29/2015 |
| These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A | Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3.
Bhattacharyya S, Feferman L, Tobacman JK., Free PMC Article | 10/11/2014 |
| Transgenic wnt9a is required for palatal extension wherein the chondrocytes form a proliferative front, undergo morphological change and intercalate to form the ethmoid plate. | Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis.
Dougherty M, Kamel G, Grimaldi M, Gfrerer L, Shubinets V, Ethier R, Hickey G, Cornell RA, Liao EC., Free PMC Article | 02/2/2013 |
| Using DirectDNA sequencing analysis, we detected ATBF1, CYLD, PARK2 and WNT9A mutations in stomach and colorectal cancers | Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability.
An CH, Kim SS, Kang MR, Kim YR, Kim HS, Yoo NJ, Lee SH. | 01/8/2011 |
| Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects. | Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia.
Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, Younesi V, Jeddi-Tehrani M, Sharifian RA, Khoshnoodi J, Razavi SM, Rabbani H, Shokri F. | 03/29/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.
Lee DY, Kim H, Ku SY, Kim SH, Choi YM, Kim JG. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. | 06/24/2009 |
| These results suggests the expression level of human Wnt9a in MCF-7 that breast cancer may play a role in adjusting the rate of cellular proliferation. | Knocking down Wnt9a mRNA levels increases cellular proliferation.
Xiang Y, Lin G, Zhang Q, Tan Y, Lu G. | 01/21/2010 |
| cDNA gene expression array of Wnt signaling pathway target genes demonstrated significant changes, including 4.5-fold induction of Wnt 9A and suppression of Dickkopf 3 and RHOU genes. | Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes.
Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK. | 01/21/2010 |
| 5'-flanking promoter region was significantly divergent between human WNT9A and rodent Wnt9a genes. | Comparative genomics on Wnt9a orthologs.
Katoh Y, Katoh M. | 01/21/2010 |
| Found clustered with WNT3A on 1q42. . | Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster.
Katoh M. | 01/21/2010 |