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    WNT1 Wnt family member 1 [ Homo sapiens (human) ]

    Gene ID: 7471, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Exome sequencing identified mutations in the WNT1 and COL1A2 genes in osteogenesis imperfecta cases.

    Exome sequencing identified mutations in the WNT1 and COL1A2 genes in osteogenesis imperfecta cases.
    Mehta P, Vishvkarma R, Gupta S, Chattopadhyay N, Rajender S.

    04/10/2024
    Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases.

    Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases.
    Shree Harini K, Ezhilarasan D.

    07/13/2023
    KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway.

    KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway.
    Li Y, Wang Y, Zou Q, Li S, Zhang F.

    06/29/2023
    Genotypic and Phenotypic Spectrum and Pathogenesis of WNT1 Variants in a Large Cohort of Patients With OI/Osteoporosis.

    Genotypic and Phenotypic Spectrum and Pathogenesis of WNT1 Variants in a Large Cohort of Patients With OI/Osteoporosis.
    Hu J, Lin X, Gao P, Zhang Q, Zhou B, Wang O, Jiang Y, Xia W, Xing X, Li M., Free PMC Article

    06/22/2023
    Association of Membranous WNT-1 and Nuclear mTOR with Endometrial Cancer Grade.

    Association of Membranous WNT-1 and Nuclear mTOR with Endometrial Cancer Grade.
    Pietrus M, Pitynski K, Waligora M, Milian-Ciesielska K, Ludwin A, Socha MW, Skrzypek K., Free PMC Article

    05/22/2023
    Osteoporosis related to WNT1 variants: a not infrequent cause of osteoporosis.

    Osteoporosis related to WNT1 variants: a not infrequent cause of osteoporosis.
    Peris P, Monegal A, Mäkitie RE, Guañabens N, González-Roca E.

    01/28/2023
    Suppression of Wnt/beta-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.

    Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease.
    Macyczko JR, Wang N, Zhao J, Ren Y, Lu W, Ikezu TC, Zhao N, Liu CC, Bu G, Li Y., Free PMC Article

    12/31/2022
    In silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis.

    In silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis.
    Mondal A, Paul D, Dastidar SG, Saha T, Goswami AM., Free PMC Article

    09/24/2022
    WNT1 expression influences the development of dysplasia of the hip via regulating RBPMS2/NOG-BMP2/4-GDF5- WISP2 pathway.

    WNT1 expression influences the development of dysplasia of the hip via regulating RBPMS2/NOG-BMP2/4-GDF5- WISP2 pathway.
    Xu J, Ye W, Li H, Xu L.

    08/27/2022
    MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells.

    MiR-140 targets Wnt1 to inhibit the proliferation and enhance drug sensitivity in osteosarcoma cells.
    Zhi W, Feng Q, Mingzhu Z.

    07/16/2022
    Wnt/beta-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinoma.

    Wnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinoma.
    Kal S, Chakraborty S, Karmakar S, Ghosh MK.

    02/19/2022
    MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1).

    MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1).
    Song GL, Xiao M, Wan XY, Deng J, Ling JD, Tian YG, Li M, Yin J, Zheng RY, Tang Y, Liu GY., Free PMC Article

    02/19/2022
    Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and beta-catenin Expression in Operable Non-small Cell Lung Cancer.

    Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer.
    Wrona A, Sejda A, Dziadziuszko R, Jassem J., Free PMC Article

    12/11/2021
    Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm.

    Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm.
    Markouli C, De Deckersberg EC, Dziedzicka D, Regin M, Franck S, Keller A, Gheldof A, Geens M, Sermon K, Spits C., Free PMC Article

    12/4/2021
    Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/beta-catenin signaling pathway.

    Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway.
    Zhang B, Li R, Wang W, Zhou X, Luo B, Zhu Z, Zhang X, Ding A., Free PMC Article

    11/13/2021
    Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid beta1-42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling.

    Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid β1-42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling.
    Sedighi M, Baluchnejadmojarad T, Afshin-Majd S, Amiri M, Aminzade M, Roghani M.

    08/28/2021
    The role of WNT1 mutant variant (WNT1(c.677C>T) ) in osteogenesis imperfecta.

    The role of WNT1 mutant variant (WNT1(c.677C>T) ) in osteogenesis imperfecta.
    Zhang B, Li R, Wang W, Zhou X, Luo B, Zhu Z, Zhang X, Ding A., Free PMC Article

    07/3/2021
    LINC00476 Suppresses the Progression of Non-Small Cell Lung Cancer by Inducing the Ubiquitination of SETDB1.

    LINC00476 Suppresses the Progression of Non-Small Cell Lung Cancer by Inducing the Ubiquitination of SETDB1.
    Cui G, Fu X, Wang W, Chen X, Liu S, Cao P, Zhao S.

    05/1/2021
    M2-like tumor-associated macrophages-secreted Wnt1 and Wnt3a promotes dedifferentiation and metastasis via activating beta-catenin pathway in thyroid cancer.

    M2-like tumor-associated macrophages-secreted Wnt1 and Wnt3a promotes dedifferentiation and metastasis via activating β-catenin pathway in thyroid cancer.
    Lv J, Feng ZP, Chen FK, Liu C, Jia L, Liu PJ, Yang CZ, Hou F, Deng ZY.

    02/20/2021
    PYGB Promoted Tumor Progression by Regulating Wnt/beta-Catenin Pathway in Gastric Cancer.

    PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer.
    Xia B, Zhang K, Liu C., Free PMC Article

    01/9/2021
    WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/beta-catenin pathway.

    WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway.
    Li B, Guo X, Li N, Chen Q, Shen J, Huang X, Huang G, Wang F., Free PMC Article

    01/2/2021
    Long non-coding RNA MIR503HG serves as a tumor suppressor in non-small cell lung cancer mediated by wnt1.

    Long non-coding RNA MIR503HG serves as a tumor suppressor in non-small cell lung cancer mediated by wnt1.
    Lin H, Li P, Zhang N, Cao L, Gao YF, Ping F.

    12/19/2020
    The expression and regulation of Wnt1 in tooth movement-initiated mechanotransduction.

    The expression and regulation of Wnt1 in tooth movement-initiated mechanotransduction.
    Ei Hsu Hlaing E, Ishihara Y, Odagaki N, Wang Z, Ikegame M, Kamioka H.

    12/5/2020
    Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord.

    Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord.
    González P, González-Fernández C, Campos-Martín Y, Mollejo M, Carballosa-Gautam M, Marcillo A, Norenberg M, Rodríguez FJ., Free PMC Article

    11/21/2020
    Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation.

    Defective WNT signaling may protect from articular cartilage deterioration - a quantitative MRI study on subjects with a heterozygous WNT1 mutation.
    Lehtovirta S, Mäkitie RE, Casula V, Haapea M, Niinimäki J, Niinimäki T, Peuna A, Lammentausta E, Mäkitie O, Nieminen MT.

    09/26/2020
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