| Pan-Cancer Proteomics Analysis Reveals Wiskott-Aldrich Syndrome Protein as a Potential Regulator of Programmed Death-Ligand 1. | Pan-Cancer Proteomics Analysis Reveals Wiskott-Aldrich Syndrome Protein as a Potential Regulator of Programmed Death-Ligand 1.
Hu L, Liu D, Zheng D, Lu J, Yuan X, Li Y, Shi F, Shi X, He QY, Li Q, Zhang CZ. | 10/28/2024 |
| Spectrum of WAS gene mutations in Vietnamese patients with Wiskott-Aldrich syndrome. | Spectrum of WAS gene mutations in Vietnamese patients with Wiskott-Aldrich syndrome.
Chuong HQ, Xinh PT, Tram DB, Ha NTT, Nguyen TM, Anh PNL, Van ND, Anh NHM, Dung PC, Nghia H, Vu HA. | 04/30/2024 |
| Association of Wiskott-Aldrich syndrome protein (WASp) in epigenetic regulation of B cell differentiation in non-small-cell lung cancer (NSCLC). | Association of Wiskott-Aldrich syndrome protein (WASp) in epigenetic regulation of B cell differentiation in non-small-cell lung cancer (NSCLC).
Chandnani N, Mandal A, Gupta I, Mukherjee O, Rakshit S, Shanmugam G, George M, Sarkar K. | 03/29/2024 |
| Role of Wiskott Aldrich syndrome protein in haematological malignancies: genetics, molecular mechanisms and therapeutic strategies. | Role of Wiskott Aldrich syndrome protein in haematological malignancies: genetics, molecular mechanisms and therapeutic strategies.
R P, Shanmugam G, Rakshit S, Sarkar K. | 01/29/2024 |
| Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction. | Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction.
Velnati S, Centonze S, Rossino G, Purghè B, Antona A, Racca L, Mula S, Ruffo E, Malacarne V, Malerba M, Manfredi M, Graziani A, Baldanzi G., Free PMC Article | 05/19/2023 |
| Identification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott-Aldrich syndrome. | Identification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott-Aldrich syndrome.
Ji X, Hou X, Guo X, Sun Y, Ma F, Hao J., Free PMC Article | 12/31/2022 |
| WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. | WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
Han SS, Wen KK, García-Rubio ML, Wold MS, Aguilera A, Niedzwiedz W, Vyas YM., Free PMC Article | 07/9/2022 |
| Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation. | Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation.
He M, Saeed MB, Record J, Keszei M, Gonçalves Pinho L, Vasconcelos-Fontes L, D'Aulerio R, Vieira R, Oliveira MMS, Geyer C, Bohaumilitzky L, Thiemann M, Deordieva E, Buedts L, Matias Lopes JP, Pershin D, Hammarström L, Xia Y, Zhao X, Cunningham-Rundles C, Thrasher AJ, Burns SO, Cotta-de-Almeida V, Liu C, Shcherbina A, Vandenberghe P, Westerberg LS. | 05/7/2022 |
| WASP integrates substrate topology and cell polarity to guide neutrophil migration. | WASP integrates substrate topology and cell polarity to guide neutrophil migration.
Brunetti RM, Kockelkoren G, Raghavan P, Bell GRR, Britain D, Puri N, Collins SR, Leonetti MD, Stamou D, Weiner OD., Free PMC Article | 02/19/2022 |
| Clinical and genetic analysis of 2 rare cases of Wiskott-Aldrich syndrome from Chinese minorities: Two case reports. | Clinical and genetic analysis of 2 rare cases of Wiskott-Aldrich syndrome from Chinese minorities: Two case reports.
Liu H, Wang Y, Li Y, Tao L, Zhang Y, He X, Zhou Y, Liu X, Wang Y, Li L., Free PMC Article | 05/8/2021 |
| WASP functions in immune defense and homeostasis through the regulation of actin cytoskeleton-dependent cellular processes as well as processes uncoupled with actin polymerization like nuclear transcription programs. (Review) | The role of WASp in T cells and B cells.
Sun X, Wei Y, Lee PP, Ren B, Liu C. | 04/25/2020 |
| We provide molecular evidence that the hyperactivity of X-linked neutropenia neutrophils is caused by WASp in a constitutively open conformation due to contingent phosphorylation of the critical tyrosine-293 and plasma membrane localization. | Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive.
Keszei M, Record J, Kritikou JS, Wurzer H, Geyer C, Thiemann M, Drescher P, Brauner H, Köcher L, James J, He M, Baptista MA, Dahlberg CI, Biswas A, Lane DP, Song W, Pütsep K, Vandenberghe P, Snapper SB, Westerberg LS., Free PMC Article | 09/28/2019 |
| This study shows that WASp plays a critical role in thymic output, which highly correlates with the subcellular location and level of F-actin in T cells. | Defective thymic output in WAS patients is associated with abnormal actin organization.
Li W, Sun X, Wang J, Zhao Q, Dai R, Wang Y, Zhou L, Westerberg L, Ding Y, Zhao X, Liu C., Free PMC Article | 07/6/2019 |
| the expression of WASP and WIP is frequently low or absent in anaplastic large cell lymphoma (ALCL) compared to other T cell lymphomas. | Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.
Menotti M, Ambrogio C, Cheong TC, Pighi C, Mota I, Cassel SH, Compagno M, Wang Q, Dall'Olio R, Minero VG, Poggio T, Sharma GG, Patrucco E, Mastini C, Choudhari R, Pich A, Zamo A, Piva R, Giliani S, Mologni L, Collings CK, Kadoch C, Gambacorti-Passerini C, Notarangelo LD, Anton IM, Voena C, Chiarle R., Free PMC Article | 05/11/2019 |
| This is the first study to associate somatically acquired WASP mutations with juvenile myelomonocytic leukemia (JMML)and increases insight in the complexity of the genomic landscape of JMML that shows low recurrent mutations concomitant with general hyperactivation of RAS pathway signaling. | Somatic mutations activating Wiskott-Aldrich syndrome protein concomitant with RAS pathway mutations in juvenile myelomonocytic leukemia patients.
Coppe A, Nogara L, Pizzuto MS, Cani A, Cesaro S, Masetti R, Locatelli F, Te Kronnie G, Basso G, Bortoluzzi S, Bresolin S. | 04/27/2019 |
| A novel, private, hemizygous splice site mutation in WAS gene (c.360 + 1G > C). | A novel splice site mutation in WAS gene in patient with Wiskott-Aldrich syndrome and chronic colitis: a case report.
Esmaeilzadeh H, Bordbar MR, Dastsooz H, Silawi M, Fard MAF, Adib A, Kafashan A, Tabatabaei Z, Sadeghipour F, Faghihi MA., Free PMC Article | 04/20/2019 |
| High WASP expression is associated with atherosclerotic plaques. | Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.
Ganesan R, Henkels KM, Wrenshall LE, Kanaho Y, Di Paolo G, Frohman MA, Gomez-Cambronero J., Free PMC Article | 04/20/2019 |
| WAS gene defect is an important basis for the diagnosis of WAS and related diseases | [Analysis of Correlation of WAS Gene Mutations with Clinical Phenotype].
Zheng YJ, Lu Q, Yao YH, He HL, Li JQ, Xiao PF, Hu SY. | 04/6/2019 |
| The data presented improve our understanding of the Cdc42-WASP interface and also add to the body of information available for Cdc42-effector complex formation, therapeutic targeting of which has promise for Ras-driven cancers. | Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.
Tetley GJN, Szeto A, Fountain AJ, Mott HR, Owen D., Free PMC Article | 03/9/2019 |
| study indicates that anti-inflammatory macrophage function and mucosal immune tolerance require both WASP and DOCK8, and that IL-10 signalling modulates a WASP-DOCK8 complex | WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB., Free PMC Article | 12/22/2018 |
| A novel WASP mutation (I290T) was found in an X-linked neutropenia patient and in his heterozygous mother. This mutation was located in the GTPase-binding domain. | Phenotype-based gene analysis allowed successful diagnosis of X-linked neutropenia associated with a novel WASp mutation.
Kobayashi M, Yokoyama K, Shimizu E, Yusa N, Ito M, Yamaguchi R, Imoto S, Miyano S, Tojo A. | 11/10/2018 |
| In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients. | Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
Lee PP, Lobato-Márquez D, Pramanik N, Sirianni A, Daza-Cajigal V, Rivers E, Cavazza A, Bouma G, Moulding D, Hultenby K, Westerberg LS, Hollinshead M, Lau YL, Burns SO, Mostowy S, Bajaj-Elliott M, Thrasher AJ., Free PMC Article | 09/15/2018 |
| Despite the lack of typical clinical manifestations of WAS, low expression of WASP could be associated with the pathogenesis of a subtype of inflammatory bowel disease patients. | Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene.
Ohya T, Yanagimachi M, Iwasawa K, Umetsu S, Sogo T, Inui A, Fujisawa T, Ito S., Free PMC Article | 08/18/2018 |
| expression of WASP inversely correlates with BCR-ABL1 levels and the progression of the disease in Chronic myeloid leukemia patients. downregulation of WASP contributes to the resistance to apoptosis and to BCR-ABL1-induced tumorigenesis. | BCR-ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy.
Pereira WO, De Carvalho DD, Zenteno ME, Ribeiro BF, Jacysyn JF, Sardinha LR, Zanichelli MA, Hamerschlak N, Jones GE, Pagnano KB, Castro FA, Calle Y, Amarante-Mendes GP., Free PMC Article | 06/9/2018 |
| The coverage and depth of WASP were extremely low. | Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing.
He X, Zou R, Zhang B, You Y, Yang Y, Tian X., Free PMC Article | 06/9/2018 |