| ALS-associated VRK1 R321C mutation causes proteostatic imbalance and mitochondrial defects in iPSC-derived motor neurons. | ALS-associated VRK1 R321C mutation causes proteostatic imbalance and mitochondrial defects in iPSC-derived motor neurons.
Oliveira D, Assoni AF, Alves LM, Sakugawa A, Melo US, Teles E Silva AL, Sertie AL, Caires LC, Goulart E, Ghirotto B, Carvalho VM, Ferrari MR, Zatz M. | 07/1/2024 |
| VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells. | VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells.
Navarro-Carrasco E, Monte-Serrano E, Campos-Díaz A, Rolfs F, de Goeij-de Haas R, Pham TV, Piersma SR, González-Alonso P, Jiménez CR, Lazo PA., Free PMC Article | 06/7/2024 |
| VRK1 promotes DNA-induced type I interferon production. | VRK1 promotes DNA-induced type I interferon production.
Fan Z, Wang X, Cheng H, Pan M. | 04/10/2024 |
| Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin. | Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin.
Navarro-Carrasco E, Campos-Díaz A, Monte-Serrano E, Rolfs F, de Goeij-de Haas R, Pham TV, Piersma SR, Jiménez CR, Lazo PA. | 03/6/2024 |
| Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage. | Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage.
Du N, Zhang B, Zhang Y., Free PMC Article | 08/9/2023 |
| VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases. | VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases.
Lazo PA, Morejón-García P. | 06/26/2023 |
| Downregulating vaccinia-related kinase 1 by luteolin suppresses ovarian cancer cell proliferation by activating the p53 signaling pathway. | Downregulating vaccinia-related kinase 1 by luteolin suppresses ovarian cancer cell proliferation by activating the p53 signaling pathway.
Chang X, Tamauchi S, Yoshida K, Yoshihara M, Yokoi A, Shimizu Y, Ikeda Y, Yoshikawa N, Kiyono T, Yamamoto Y, Kajiyama H. | 06/7/2023 |
| Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis. | Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis.
Tan L, Wang L, Liu J, Yu Y. | 03/8/2023 |
| VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma. | VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma.
Shields JA, Meier SR, Bandi M, Mulkearns-Hubert EE, Hajdari N, Ferdinez MD, Engel JL, Silver DJ, Shen B, Zhang W, Hubert CG, Mitchell K, Shakya S, Zhao SC, Bejnood A, Zhang M, Tjin Tham Sjin R, Wilker E, Lathia JD, Andersen JN, Chen Y, Li F, Weber B, Huang A, Emmanuel N., Free PMC Article | 11/5/2022 |
| VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. | VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.
So J, Mabe NW, Englinger B, Chow KH, Moyer SM, Yerrum S, Trissal MC, Marques JG, Kwon JJ, Shim B, Pal S, Panditharatna E, Quinn T, Schaefer DA, Jeong D, Mayhew DL, Hwang J, Beroukhim R, Ligon KL, Stegmaier K, Filbin MG, Hahn WC., Free PMC Article | 10/15/2022 |
| Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase. | Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase.
Linville AC, Rico AB, Teague H, Binsted LE, Smith GL, Albarnaz JD, Wiebe MS., Free PMC Article | 06/18/2022 |
| Inhibition of VRK1 suppresses proliferation and migration of vascular smooth muscle cells and intima hyperplasia after injury via mTORC1/beta-catenin axis. | Inhibition of VRK1 suppresses proliferation and migration of vascular smooth muscle cells and intima hyperplasia after injury via mTORC1/β-catenin axis.
Sun X, Zhao W, Wang Q, Zhao J, Yang D, Yang Y., Free PMC Article | 06/18/2022 |
| Altered action potential waveform and shorter axonal initial segment in hiPSC-derived motor neurons with mutations in VRK1. | Altered action potential waveform and shorter axonal initial segment in hiPSC-derived motor neurons with mutations in VRK1.
Bos R, Rihan K, Quintana P, El-Bazzal L, Bernard-Marissal N, Da Silva N, Jabbour R, Mégarbané A, Bartoli M, Brocard F, Delague V. | 05/21/2022 |
| VRK1 promotes proliferation, migration, and invasion of gastric carcinoma cells by activating beta-catenin. | VRK1 promotes proliferation, migration, and invasion of gastric carcinoma cells by activating β-catenin.
Wang L, Zhai R, Shen H, Song G, Wan F, Li Q. | 10/16/2021 |
| The human VRK1 chromatin kinase in cancer biology. | The human VRK1 chromatin kinase in cancer biology.
Campillo-Marcos I, García-González R, Navarro-Carrasco E, Lazo PA. | 08/7/2021 |
| HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. | HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation.
Ryu HG, Jung Y, Lee N, Seo JY, Kim SW, Lee KH, Kim DY, Kim KT., Free PMC Article | 06/26/2021 |
| VRK1 variants in two Portuguese unrelated patients with childhood-onset motor neuron disease. | VRK1 variants in two Portuguese unrelated patients with childhood-onset motor neuron disease.
Silva DP, Soeiro E Sá M, Silveira F, Pinto S, Gromicho M, Sousa AB, Leão M, De Carvalho M. | 06/12/2021 |
| Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells. | Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells.
Yokobori K, Miyauchi Y, Williams JG, Negishi M., Free PMC Article | 04/3/2021 |
| VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes. | VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.
Martín-Doncel E, Rojas AM, Cantarero L, Lazo PA., Free PMC Article | 10/31/2020 |
| Motor neuron diseases caused by a novel VRK1 variant - A genotype/phenotype study. | Motor neuron diseases caused by a novel VRK1 variant - A genotype/phenotype study.
Sedghi M, Moslemi AR, Olive M, Etemadifar M, Ansari B, Nasiri J, Emrahi L, Mianesaz HR, Laing NG, Tajsharghi H., Free PMC Article | 09/26/2020 |
| VRK1 takes part in the regulatory function of Ras-PI3K pathway on H2A(T120ph) | Ras-PI3K pathway promotes osteosarcoma progression via regulating VRK1-mediated H2A phosphorylation at threonine 120.
Xu X, Yu H. | 04/18/2020 |
| Findings support vaccinia-related kinase 1 as a causative gene for adult-onset distal hereditary motor neuropathy, and indicate its relevance for evaluation of individuals with similar motor impairment. | Identification of a homozygous VRK1 mutation in two patients with adult-onset distal hereditary motor neuropathy.
Greenbaum L, Barel O, Nikitin V, Hersalis-Eldar A, Kol N, Reznik-Wolf H, Dominissini D, Pras E, Dori A. | 04/11/2020 |
| This study reports the molecular characterization of VRK1 in complex with AMP-PNP, a non-hydrolyzable adenosine triphosphate (ATP)-analog, using NMR titration followed by the co-crystal structure determined upto 2.07 A resolution. | Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog.
Ngow YS, Rajan S, Ye H, Yoon HS., Free PMC Article | 03/28/2020 |
| Evidence for a role of VRK1 in regulating Cajal bodies assembly in motor neurons. The observed motor neurons defects are consistent with a length dependent axonopathy affecting lower and upper motor neurons. | Loss of Cajal bodies in motor neurons from patients with novel mutations in VRK1.
El-Bazzal L, Rihan K, Bernard-Marissal N, Castro C, Chouery-Khoury E, Desvignes JP, Atkinson A, Bertaux K, Koussa S, Lévy N, Bartoli M, Mégarbané A, Jabbour R, Delague V. | 03/14/2020 |
| The protective DNA damage response induced by ionizing radiation is impaired by the combination of olaparib with depletion of VRK1, and can be used to reduce doses of radiation and their associated toxicity | Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.
Campillo-Marcos I, Lazo PA., Free PMC Article | 12/21/2019 |