| USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression. | USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression.
Liu B, Zhang X, Zhou Y, Liu H, Wang Z, Fu Y, Gao Q, Cheng X, Sun Q, Ju Z. | 11/7/2024 |
| USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway. | USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway.
Hu C, Zhang W, Jia Y, Zhao J, Chen Q, Hao C, Yu Y., Free PMC Article | 10/30/2024 |
| Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer. | Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Zhou Y, Li H, Zhang Y, Zhao E, Huang C, Pan X, Shu F, Liu Z, Tang N, Li F, Liao W. | 04/25/2024 |
| USP4 regulates TUT1 ubiquitination status in concert with SART3. | USP4 regulates TUT1 ubiquitination status in concert with SART3.
Kim J, Taketomi T, Yamada A, Uematsu Y, Ueda K, Chiba T, Tsuruta F. | 02/23/2024 |
| FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. | FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
Xu J, Guo R, Wen N, Li L, Yi Y, Chen J, He Z, Yang J, Xiao ZJ, Niu M., Free PMC Article | 01/10/2024 |
| USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1. | USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.
Zhang H, Han Y, Xiao W, Gao Y, Sui Z, Ren P, Meng F, Tang P, Yu Z., Free PMC Article | 11/14/2023 |
| High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients. | High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients.
Scheiflinger A, Al-Gboore S, Jank BJ, Brkic F, Kadletz-Wanke L, Kenner L, Heiduschka G, Schnoell J., Free PMC Article | 08/20/2023 |
| Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells. | Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.
Yun SI, Kwak C, Lee SY, Shin S, Oh C, Kim JS, Rhee HW, Kim KK. | 04/14/2023 |
| The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-kappaB Signaling by Regulating PRL-3 Expression. | The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-κB Signaling by Regulating PRL-3 Expression.
Tao Y, You W. | 11/19/2022 |
| Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Ubiquitination-Related Signature in Glioma and Identified USP4 as a Novel Biomarker. | Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Ubiquitination-Related Signature in Glioma and Identified USP4 as a Novel Biomarker.
Tang Q, Chen Z, Xie J, Mo C, Lu J, Zhang Q, Wang Z, Wu W, Wang H., Free PMC Article | 07/16/2022 |
| Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRbeta and affect PDGF-BB-induced STAT3 signalling. | Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling.
Sarri N, Wang K, Tsioumpekou M, Castillejo-López C, Lennartsson J, Heldin CH, Papadopoulos N., Free PMC Article | 02/5/2022 |
| Ubiquitin-specific protease 4 predicts an unfavorable prognosis and promotes malignant behaviors in vitro in pancreatic cancer. | Ubiquitin-specific protease 4 predicts an unfavorable prognosis and promotes malignant behaviors in vitro in pancreatic cancer.
Wang Y, Zhou L, Lu J, Jiang B, Liu C, Liang Z, Zhou W, Guo J. | 03/13/2021 |
| The Effects of the Transforming Growth Factor-beta1 (TGF-beta1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. | The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures.
Huang Y, Wang Y, Wang X, Lin L, Wang P, Sun J, Jiang L., Free PMC Article | 01/9/2021 |
| modifications of USP15 and USP4 by phosphorylation are important for the regulation of their localization required for cellular function in the spliceosome. | Phosphorylation of USP15 and USP4 Regulates Localization and Spliceosomal Deubiquitination.
Das T, Kim EE, Song EJ. | 06/20/2020 |
| a novel H19/miR-148a/USP4 axis which promoted liver fibrosis via TGF-beta pathway in both hepatic stellate cells and hepatocytes, is reported. | H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes.
Zhu J, Luo Z, Pan Y, Zheng W, Li W, Zhang Z, Xiong P, Xu D, Du M, Wang B, Yu J, Zhang J, Liu J. | 04/18/2020 |
| functions as a pivotal suppressor in nonalcoholic fatty liver disease | Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Metabolic Dysfunctions in Nonalcoholic Fatty Liver Disease in Mice.
Zhao Y, Wang F, Gao L, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Pu J. | 12/28/2019 |
| USP4 directly interacts with and deubiquitinates TGFR-1 to increase TGF-beta signaling-induced epithelial-mesenchymal transition, promoting hepatocellular carcinoma metastasis. | Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition.
Qiu C, Liu Y, Mei Y, Zou M, Zhao Z, Ye M, Wu X., Free PMC Article | 11/23/2019 |
| the up-regulated USP4 plays an oncogenic role in melanoma by simultaneously suppressing stress-induced cell apoptosis and facilitating tumour metastasis. | Up-regulated deubiquitinase USP4 plays an oncogenic role in melanoma.
Guo W, Ma J, Pei T, Zhao T, Guo S, Yi X, Liu Y, Wang S, Zhu G, Jian Z, Gao T, Li C, Liao W, Shi Q., Free PMC Article | 10/26/2019 |
| cyclophilin A (CypA) was identified as an important molecule for USP4-mediated oncogenic activity in hepatocellular carcinoma. | Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression via cyclophilin A stabilization and deubiquitination.
Li T, Yan B, Ma Y, Weng J, Yang S, Zhao N, Wang X, Sun X., Free PMC Article | 08/3/2019 |
| USP4 expression was significantly down-regulated in lung adenocarcinoma. USP4 expression might be a favorable biomarker in terms of overall survival and recurrence-free survival in the lung adenocarcinoma patients. | USP4 expression independently predicts favorable survival in lung adenocarcinoma.
Zhong M, Jiang Q, Jin R. | 06/8/2019 |
| We show here that mutating the active site cysteine of human USP4 and yeast Ubp8 to alanine increases the affinity of the DUB for mono- or diubiquitin by 10-150-fold. | Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
Morrow ME, Morgan MT, Clerici M, Growkova K, Yan M, Komander D, Sixma TK, Simicek M, Wolberger C., Free PMC Article | 06/8/2019 |
| Study provide a novel mechanistic insight into the growth-regulatory role of TRPS1-USP4-HDAC2 axis by providing evidence that TRPS1 recruits USP4 to deubiquitinate and stabilize HDAC2. This is the first example of the non-transcription factor function of GATA transcription factor which affects the ubiquitination and transcription repressive function of HDAC2, acetylation of H4K16, and the deubiquitinase function of USP4. | Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth.
Wang Y, Zhang J, Wu L, Liu W, Wei G, Gong X, Liu Y, Ma Z, Ma F, Thiery JP, Chen L., Free PMC Article | 05/25/2019 |
| Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues. | Ubiquitin-specific protease 4 improves the prognosis of the patients in esophageal cancer.
Yao R, Pu J, Fan R, Zhu W, Ding X, Shen X, Zhang T. | 06/9/2018 |
| The data indicate that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease. | Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells.
Guo Z, Xu P, Ge S, Zhang C, Zheng X, Xu J, Liu Z, Li B, Ge S., Free PMC Article | 05/19/2018 |
| These results identify USP4 as a novel regulator of Dvl in Wnt/beta-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation | Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled.
Zhou F, Li F, Fang P, Dai T, Yang B, van Dam H, Jia J, Zheng M, Zhang L. | 12/16/2017 |