| UDP-glucose ceramide glucosyltransferase specifically upregulated in plasmacytoid dendritic cells regulates type I interferon production upon CpG stimulation. | UDP-glucose ceramide glucosyltransferase specifically upregulated in plasmacytoid dendritic cells regulates type I interferon production upon CpG stimulation.
Sato Y, Osada E, Ushiki T, Maeda T, Manome Y. | 10/16/2024 |
| Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding alpha-Synuclein, beta-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression. | Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.
Brazdis RM, von Zimmermann C, Lenz B, Kornhuber J, Mühle C., Free PMC Article | 04/2/2024 |
| Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models. | Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.
La Monica S, Vacondio F, Eltayeb K, Lodola A, Volta F, Viglioli M, Ferlenghi F, Galvani F, Galetti M, Bonelli M, Fumarola C, Cavazzoni A, Flammini L, Verzè M, Minari R, Petronini PG, Tiseo M, Mor M, Alfieri R., Free PMC Article | 03/20/2024 |
| Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides. | Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR., Free PMC Article | 09/25/2023 |
| Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease. | Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.
Komuro M, Nagane M, Endo R, Nakamura T, Miyamoto T, Niwa C, Fukuyama T, Harashima H, Aihara N, Kamiie J, Suzuki R, Yamashita T. | 03/19/2022 |
| UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway. | UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway.
Zhang F, Zhang H. | 02/12/2022 |
| beta-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model. | β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model.
Takeda S, Terazawa S, Shimoda H, Imokawa G., Free PMC Article | 10/16/2021 |
| Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide. | Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.
Honda T, Motoyoshi K, Kasahara J, Yamagata K, Takahashi H, Nakamura H, Murayama T. | 04/17/2021 |
| UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells. | UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells.
Schömel N, Gruber L, Alexopoulos SJ, Trautmann S, Olzomer EM, Byrne FL, Hoehn KL, Gurke R, Thomas D, Ferreirós N, Geisslinger G, Wegner MS., Free PMC Article | 12/5/2020 |
| UGCG influences glutamine metabolism of breast cancer cells. | UGCG influences glutamine metabolism of breast cancer cells.
Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS., Free PMC Article | 11/21/2020 |
| the GCS inhibitor lucerastat provides a viable mechanism to reduce Gb3 accumulation and lysosome volume, suitable for all Fabry patients regardless of genotype | Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types.
Welford RWD, Mühlemann A, Garzotti M, Rickert V, Groenen PMA, Morand O, Üçeyler N, Probst MR., Free PMC Article | 03/30/2019 |
| findings suggest that complex formation between SMS1 and GCS is part of a critical mechanism controlling the metabolic fate of Cer in the Golgi. | Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.
Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, Saeki T, Kumasaka T, Koizumi T, Arai S, Wada I, Yokoyama K, Sugiura T, Yamashita A., Free PMC Article | 03/23/2019 |
| Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG) and multidrug resistance protein 1 (MDR1) overexpression and multidrug resistance development [Review]. | The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1).
Wegner MS, Gruber L, Mattjus P, Geisslinger G, Grösch S., Free PMC Article | 08/25/2018 |
| Results suggest that the changes of DNA methylation status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer. | Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.
Liu J, Zhang X, Liu A, Zhang D, Su Y, Liu Y, You D, Yuan L, Kong X, Wang X, Sun P., Free PMC Article | 12/30/2017 |
| Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma. | Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma.
Stefanovic M, Tutusaus A, Martinez-Nieto GA, Bárcena C, de Gregorio E, Moutinho C, Barbero-Camps E, Villanueva A, Colell A, Marí M, García-Ruiz C, Fernandez-Checa JC, Morales A., Free PMC Article | 12/24/2016 |
| GCS was upregulated in colorectal carcinoma tissues compared to control tissues. | Expression and significance of glucosylceramide synthase in colorectal carcinoma tissues.
Wang C, Liu JN, Xu L, Mu YL, Sun P. | 08/29/2015 |
| We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women. | Dysregulated sphingolipid metabolism in endometriosis.
Lee YH, Tan CW, Venkatratnam A, Tan CS, Cui L, Loh SF, Griffith L, Tannenbaum SR, Chan JK., Free PMC Article | 01/24/2015 |
| Our data demonstrates a correlation between the expression of the GCS protein and ER-positive/HER-2 negative breast cancer | Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status.
Liu J, Sun P, Sun Y, Liu A, You D, Jiang F, Sun Y., Free PMC Article | 09/6/2014 |
| our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD. | Characterization of variants in the glucosylceramide synthase gene and their association with type 1 Gaucher disease severity.
Alfonso P, Navascués J, Navarro S, Medina P, Bolado-Carrancio A, Andreu V, Irún P, Rodríguez-Rey JC, Pocoví M, España F, Giraldo P. | 07/26/2014 |
| GCS was upregulated in PTCs and might be an independent factor affecting prognosis. | Upregulation of glucosylceramide synthase protein in papillary thyroid carcinoma.
Zhang K, Song YH, Lin XY, Wang QX, Zhang HW, Xu JW. | 06/28/2014 |
| Glucosylceramide synthase mRNA were reduced by 62%. | [NF-κ B mediates the effect of glucosylceramide synthase on P-glycoprotein modulation in a drug-resistance leukemia cell line].
Zhang X, Xie K, Zou J, Li Y, Mu H, Zhang B, Xie P. | 03/29/2014 |
| The results thus show that ARF6 regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels. | ARF6 regulates neuron differentiation through glucosylceramide synthase.
Li L, Ståhlman M, Rutberg M, Håversen L, Fogelstrand P, Andersson L, Levin M, Borén J., Free PMC Article | 10/19/2013 |
| DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells | Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancer.
Zhang X, Wu X, Su P, Gao Y, Meng B, Sun Y, Li L, Zhou Z, Zhou G., Free PMC Article | 05/11/2013 |
| Ceramide glycosylation catalyzed by glucosylceramide synthase is important for cancer stem cells in drug resistance and tumorigenesis. | Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.
Gupta V, Bhinge KN, Hosain SB, Xiong K, Gu X, Shi R, Ho MY, Khoo KH, Li SC, Li YT, Ambudkar SV, Jazwinski SM, Liu YY., Free PMC Article | 01/12/2013 |
| Data indicate that a high expression of glucosylceramide synthase (GCS) seemed to be an indicator of poor prognosis. | Up-regulation of glucosylceramide synthase in urinary bladder neoplasms.
Sun CC, Zhang Z, Zhang SY, Li J, Li ZL, Kong CZ. | 12/8/2012 |