| TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco. | TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Benmansour R, Tagajdid MR, El Hamzaoui H, Fjouji S, Doghmi N, Houba A, Belbacha I, Elkochri S, Aabi R, Elannaz H, Laraqui A, El Mchichi B, Chmitah T, Touil N, Ennibi K, Eljaoudi R, Elmir E, Amine Lahlou I, Oumzil H., Free PMC Article | 08/16/2024 |
| Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population. | Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.
Zhang M, Liu Z, Zhu Y, Wu K, Zhou L, Peng Y, Pan J, Chen B, Wang X, Chen S., Free PMC Article | 06/25/2024 |
| Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2. | Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
Lesgidou N, Vlassi M. | 03/8/2024 |
| Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. | Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
Yang Z, Xiang Q, Nicholas J., Free PMC Article | 12/20/2023 |
| Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2. | Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
Gracias S, Chazal M, Decombe A, Unterfinger Y, Sogues A, Pruvost L, Robert V, Lacour SA, Lemasson M, Sourisseau M, Li Z, Richardson J, Pellegrini S, Decroly E, Caval V, Jouvenet N., Free PMC Article | 12/18/2023 |
| The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia. | The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
Zhu L, Li X, Liu D, Bai W, Yang H, Cheng Q, Xu L, Fang J. | 07/31/2023 |
| TYK2 single-nucleotide variants associated with the severity of COVID-19 disease. | TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
Zabihi Rizi F, Ghorbani A, Zahtab P, Darbaghshahi NN, Ataee N, Pourhamzeh P, Hamzei B, Dolatabadi NF, Zamani A, Hooshmand M., Free PMC Article | 03/28/2023 |
| Tyk2 Targeting in Immune-Mediated Inflammatory Diseases. | Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
Rusiñol L, Puig L., Free PMC Article | 03/1/2023 |
| Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19. | Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Dieter C, de Almeida Brondani L, Lemos NE, Schaeffer AF, Zanotto C, Ramos DT, Girardi E, Pellenz FM, Camargo JL, Moresco KS, da Silva LL, Aubin MR, de Oliveira MS, Rech TH, Canani LH, Gerchman F, Leitão CB, Crispim D., Free PMC Article | 02/11/2023 |
| Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway. | Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
Loo WJ, Turchin I, Prajapati VH, Gooderham MJ, Grewal P, Hong CH, Sauder M, Vender RB, Maari C, Papp KA. | 02/4/2023 |
| The type 1 diabetes gene TYK2 regulates beta-cell development and its responses to interferon-alpha. | The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T., Free PMC Article | 11/5/2022 |
| Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. | Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
Yarmolinsky J, Amos CI, Hung RJ, Moreno V, Burrows K, Smith-Byrne K, Atkins JR, Brennan P, Colon Cancer Family Registry (CCFR), Colorectal Cancer Transdisciplinary Study (CORECT), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium, McKay JD, Martin RM, Davey Smith G., Free PMC Article | 10/29/2022 |
| Impaired IL-23-dependent induction of IFN-gamma underlies mycobacterial disease in patients with inherited TYK2 deficiency. | Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.
Ogishi M, Arias AA, Yang R, Han JE, Zhang P, Rinchai D, Halpern J, Mulwa J, Keating N, Chrabieh M, Lainé C, Seeleuthner Y, Ramírez-Alejo N, Nekooie-Marnany N, Guennoun A, Muller-Fleckenstein I, Fleckenstein B, Kilic SS, Minegishi Y, Ehl S, Kaiser-Labusch P, Kendir-Demirkol Y, Rozenberg F, Errami A, Zhang SY, Zhang Q, Bohlen J, Philippot Q, Puel A, Jouanguy E, Pourmoghaddas Z, Bakhtiar S, Willasch AM, Horneff G, Llanora G, Shek LP, Chai LYA, Tay SH, Rahimi HH, Mahdaviani SA, Nepesov S, Bousfiha AA, Erdeniz EH, Karbuz A, Marr N, Navarrete C, Adeli M, Hammarstrom L, Abolhassani H, Parvaneh N, Al Muhsen S, Alosaimi MF, Alsohime F, Nourizadeh M, Moin M, Arnaout R, Alshareef S, El-Baghdadi J, Genel F, Sherkat R, Kiykim A, Yücel E, Keles S, Bustamante J, Abel L, Casanova JL, Boisson-Dupuis S., Free PMC Article | 10/1/2022 |
| Novel mutations of TYK2 leading to divergent clinical phenotypes. | Novel mutations of TYK2 leading to divergent clinical phenotypes.
Lv G, Sun G, Wu P, Du X, Zeng T, Wen W, Zhou L, An Y, Tang X, He T, Zhao X, Du H. | 07/2/2022 |
| Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia. | Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncada-Velez M, Kendir-Demirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, COVID Human Genetic Effort, Bayhan GI, Keles S, Kiykim A, Hancerli S, Haerynck F, Florkin B, Hatipoglu N, Ozcelik T, Morelle G, Zatz M, Ng LFP, Lye DC, Young BE, Leo YS, Dalgard CL, Lifton RP, Renia L, Meyts I, Jouanguy E, Hammarström L, Pan-Hammarström Q, Boisson B, Bastard P, Su HC, Boisson-Dupuis S, Abel L, Rice CM, Zhang SY, Cobat A, Casanova JL., Free PMC Article | 06/25/2022 |
| Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients. | Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.
Akbari M, Akhavan-Bahabadi M, Shafigh N, Taheriazam A, Hussen BM, Sayad A, Fathi M, Taheri M, Ghafouri-Fard S, Fathi M., Free PMC Article | 04/23/2022 |
| The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus. | The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus.
Pellenz FM, Dieter C, Duarte GCK, Canani LH, de Souza BM, Crispim D., Free PMC Article | 03/12/2022 |
| Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia. | Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia.
Tavakoli Shirazi P, Eadie LN, Page EC, Heatley SL, Bruning JB, White DL. | 11/22/2021 |
| Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population. | Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.
Liu C, Yan S, Chen H, Wu Z, Li L, Cheng L, Li H, Li Y., Free PMC Article | 09/25/2021 |
| TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients. | TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.
Mori H, Takahashi H, Mine K, Higashimoto K, Inoue K, Kojima M, Kuroki S, Eguchi T, Ono Y, Inuzuka S, Soejima H, Nagafuchi S, Anzai K., Free PMC Article | 08/7/2021 |
| TYK2 Variants in B-Acute Lymphoblastic Leukaemia. | TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
Turrubiartes-Martínez E, Bodega-Mayor I, Delgado-Wicke P, Molina-Jiménez F, Casique-Aguirre D, González-Andrade M, Rapado I, Camós M, Díaz-de-Heredia C, Barragán E, Ramírez-Orellana M, Aguado B, Figuera Á, Martínez-López J, Fernández-Ruiz E., Free PMC Article | 07/24/2021 |
| Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population. | Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population.
Peng Y, Chen B, Sheng X, Qian Y., Free PMC Article | 05/29/2021 |
| JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. | JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma.
Meng L, Ding L, Yu Y, Li W., Free PMC Article | 05/8/2021 |
| Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years. | Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years.
Kerner G, Laval G, Patin E, Boisson-Dupuis S, Abel L, Casanova JL, Quintana-Murci L., Free PMC Article | 03/27/2021 |
| A New Patient with Inherited TYK2 Deficiency. | A New Patient with Inherited TYK2 Deficiency.
Sarrafzadeh SA, Mahloojirad M, Casanova JL, Badalzadeh M, Bustamante J, Boisson-Dupuis S, Pourpak Z, Nourizadeh M, Moin M., Free PMC Article | 02/13/2021 |