| Identification of MKI67, TPR , and TCHH Mutations as Prognostic Biomarkers for Patients With Defective Mismatch Repair Colon Cancer Stage II/III. | Identification of MKI67, TPR , and TCHH Mutations as Prognostic Biomarkers for Patients With Defective Mismatch Repair Colon Cancer Stage II/III.
Lv J, Li W, Wang X, Guo L, Wang D, Zhang Y, Yu J, Chen T, Niu B, Wang X, Liu Z. | 11/1/2023 |
| Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells. | Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells.
Chen M, Long Q, Borrie MS, Sun H, Zhang C, Yang H, Shi D, Gartenberg MR, Deng W., Free PMC Article | 01/8/2022 |
| Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma. | Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.
Dewi FRP, Jiapaer S, Kobayashi A, Hazawa M, Ikliptikawati DK, Hartono, Sabit H, Nakada M, Wong RW., Free PMC Article | 11/27/2021 |
| ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR. | ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.
Gunkel P, Iino H, Krull S, Cordes VC., Free PMC Article | 11/22/2021 |
| Cancer-related SRCAP and TPR mutations in colon cancers. | Cancer-related SRCAP and TPR mutations in colon cancers.
Moon SW, Mo HY, Choi EJ, Yoo NJ, Lee SH. | 10/16/2021 |
| The human nucleoporin Tpr protects cells from RNA-mediated replication stress. | The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
Kosar M, Giannattasio M, Piccini D, Maya-Mendoza A, García-Benítez F, Bartkova J, Barroso SI, Gaillard H, Martini E, Restuccia U, Ramirez-Otero MA, Garre M, Verga E, Andújar-Sánchez M, Maynard S, Hodny Z, Costanzo V, Kumar A, Bachi A, Aguilera A, Bartek J, Foiani M., Free PMC Article | 07/17/2021 |
| TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes. | TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes.
Lee ES, Wolf EJ, Ihn SSJ, Smith HW, Emili A, Palazzo AF., Free PMC Article | 02/6/2021 |
| TPR contributes to the organization of the nuclear lamina and in cooperation with lamin B1 and lamin A-C guards the interphase assembly of nuclear pore complexes. | Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution.
Fišerová J, Maninová M, Sieger T, Uhlířová J, Šebestová L, Efenberková M, Čapek M, Fišer K, Hozák P., Free PMC Article | 05/25/2019 |
| TPR is necessary for both formation and maintenance of senescence-associated heterochromatin foci | Nuclear pore density controls heterochromatin reorganization during senescence.
Boumendil C, Hari P, Olsen KCF, Acosta JC, Bickmore WA., Free PMC Article | 03/2/2019 |
| Fusion of TPR(2-142) protein to the MET intracellular domain strongly and selectively stabilizes the alphaG helix of the MET kinase domain.TPR has an ability to induce dimerization and activation of fusion kinases. | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Pal K, Bandyopadhyay A, Zhou XE, Xu Q, Marciano DP, Brunzelle JS, Yerrum S, Griffin PR, Vande Woude G, Melcher K, Xu HE., Free PMC Article | 03/24/2018 |
| Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area. | AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint.
López-Soop G, Rønningen T, Rogala A, Richartz N, Blomhoff HK, Thiede B, Collas P, Küntziger T., Free PMC Article | 03/10/2018 |
| Report mutual regulation between Tpr and Aurora A and further confirm the importance of nucleoporin function in spindle pole organization, bipolar spindle assembly, and mitosis. | Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.
Kobayashi A, Hashizume C, Dowaki T, Wong RW., Free PMC Article | 02/27/2016 |
| Tpr maintains a chromatin environment favourable for HIV replication. | Chromatin organization at the nuclear pore favours HIV replication.
Lelek M, Casartelli N, Pellin D, Rizzi E, Souque P, Severgnini M, Di Serio C, Fricke T, Diaz-Griffero F, Zimmer C, Charneau P, Di Nunzio F., Free PMC Article | 02/20/2016 |
| SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. | Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.
Jaberi A, Hooker E, Guillemette J, Papillon J, Kristof AS, Cybulsky AV. | 12/5/2015 |
| Protein kinase A phosphorylates the S2094 residue and that the site is hyperphosphorylated during mitosis. | Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function.
Rajanala K, Sarkar A, Jhingan GD, Priyadarshini R, Jalan M, Sengupta S, Nandicoori VK., Free PMC Article | 05/16/2015 |
| analysis of interactions between CRM1 and the nuclear pore protein Tpr and snurportin | The interaction of CRM1 and the nuclear pore protein Tpr.
Zhao CL, Mahboobi SH, Moussavi-Baygi R, Mofrad MR., Free PMC Article | 01/17/2015 |
| Tpr is a kinetochore-independent, rate-limiting factor required to mount and sustain a robust SAC response. | Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis.
Schweizer N, Ferrás C, Kern DM, Logarinho E, Cheeseman IM, Maiato H., Free PMC Article | 04/12/2014 |
| Tpr import is mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in Tpr with nanomolar affinity | Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.
Snow CJ, Dar A, Dutta A, Kehlenbach RH, Paschal BM., Free PMC Article | 07/20/2013 |
| Tpr depletion increased p53 nuclear accumulation and facilitated autophagy. | Regulation of autophagy by nucleoporin Tpr.
Funasaka T, Tsuka E, Wong RW., Free PMC Article | 04/27/2013 |
| Exon 23 of the translocated promoter region gene was fused to exon 13 of FGFR1 resulting in 8p11 myeloproliferative syndrome. | Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11 myeloproliferative syndrome.
Li F, Zhai YP, Tang YM, Wang LP, Wan PJ. | 12/8/2012 |
| Perinuclear localization of Tpr at the nucleopore complex is crucial for regulating intron containing mRNA export. | Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.
Rajanala K, Nandicoori VK., Free PMC Article | 06/2/2012 |
| Depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately induces a senescent-like phenotype dependent on the presence of p53. | Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells.
David-Watine B., Free PMC Article | 12/10/2011 |
| Tpr plays an important role in quality control of mRNA trafficked on the Nxf1 pathway. | The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway.
Coyle JH, Bor YC, Rekosh D, Hammarskjold ML., Free PMC Article | 09/3/2011 |
| Tpr has a role as a determinant of perinuclear organization, with a direct role in forming a morphologically distinct nuclear sub-compartment and delimiting heterochromatin distribution | Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.
Krull S, Dörries J, Boysen B, Reidenbach S, Magnius L, Norder H, Thyberg J, Cordes VC., Free PMC Article | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |