| A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells. | A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells.
Hu R, Hameed UFS, Sun X, Moorthy BS, Zhang W, Jeffrey PD, Zhou L, Ma X, Chen F, Pei J, Giri PK, Mou Y, Swaminathan K, Yuan P., Free PMC Article | 01/14/2023 |
| The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. | The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer.
Nelczyk AT, Ma L, Gupta AD, Gamage HEV, McHenry MT, Henn MA, Kadiri M, Wang Y, Krawczynska N, Bendre S, He S, Shahoei SH, Madak-Erdogan Z, Hsiao SH, Saleh T, Carpenter V, Gewirtz DA, Spinella MJ, Nelson ER., Free PMC Article | 10/1/2022 |
| TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease. | TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease.
Nelson AT, Wang Y, Nelson ER., Free PMC Article | 01/15/2022 |
| Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma. | Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma.
Zhou J, Pei X, Yang Y, Wang Z, Gao W, Ye R, Zhang X, Liu J, Liu Z, Yang X, Tao J, Gu C, Hu W, Chan FL, Li X, Mao J, Wu D., Free PMC Article | 12/18/2021 |
| Tumorigenic effects of TLX overexpression in HEK 293T cells. | Tumorigenic effects of TLX overexpression in HEK 293T cells.
Parris TZ, Vizlin-Hodzic D, Salmela S, Funa K., Free PMC Article | 10/9/2021 |
| Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia. | Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia.
Wang YY, Hsu SH, Tsai HY, Cheng MC. | 02/27/2021 |
| ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner. | ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.
Sobhan PK, Zhai Q, Green LC, Hansford LM, Funa K. | 12/2/2017 |
| The interaction between TLX and TGF-beta may play an important role in the regulation of proliferation and tumor-initiating properties of glioblastoma cells. | Nuclear receptor TLX inhibits TGF-β signaling in glioblastoma.
Johansson E, Zhai Q, Zeng ZJ, Yoshida T, Funa K. | 05/13/2017 |
| TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. | The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs AD, Song H, Ming GL, Shi Y., Free PMC Article | 07/30/2016 |
| TLX downregulation induces TET3 expression and inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells. | Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.
Cui Q, Yang S, Ye P, Tian E, Sun G, Zhou J, Sun G, Liu X, Chen C, Murai K, Zhao C, Azizian KT, Yang L, Warden C, Wu X, D'Apuzzo M, Brown C, Badie B, Peng L, Riggs AD, Rossi JJ, Shi Y., Free PMC Article | 07/2/2016 |
| TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells | Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer.
Lin ML, Patel H, Remenyi J, Banerji CR, Lai CF, Periyasamy M, Lombardo Y, Busonero C, Ottaviani S, Passey A, Quinlan PR, Purdie CA, Jordan LB, Thompson AM, Finn RS, Rueda OM, Caldas C, Gil J, Coombes RC, Fuller-Pace FV, Teschendorff AE, Buluwela L, Ali S., Free PMC Article | 06/11/2016 |
| TLX biological role in mental illness and gliomagenesis | TLX: An elusive receptor.
Benod C, Villagomez R, Webb P. | 06/4/2016 |
| Increased NR2E1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. | The relationship between NR2E1 and subclinical inflammation in newly diagnosed type 2 diabetic patients.
Sun L, Deng H, He L, Hu X, Huang Q, Xue J, Chen J, Shi X, Xu Y. | 04/16/2016 |
| These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro | Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro.
Ni N, Zhang D, Xie Q, Chen J, Wang Z, Deng Y, Wen X, Zhu M, Ji J, Fan X, Luo M, Gu P., Free PMC Article | 10/31/2015 |
| NR2E1 regulates CBX7 and restrains senescence in neural stem cells. | The nuclear receptor NR2E1/TLX controls senescence.
O'Loghlen A, Martin N, Krusche B, Pemberton H, Alonso MM, Chandler H, Brookes S, Parrinello S, Peters G, Gil J., Free PMC Article | 10/24/2015 |
| TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes | Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.
Wu D, Yu S, Jia L, Zou C, Xu Z, Xiao L, Wong KB, Ng CF, Chan FL. | 07/25/2015 |
| The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation. | TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival.
Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K., Free PMC Article | 06/20/2015 |
| TLX is involved in interleukin (IL)-1beta-induced changes in adult hippocampal neurogenesis. | Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.
Ryan SM, O'Keeffe GW, O'Connor C, Keeshan K, Nolan YM. | 05/10/2014 |
| TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene. | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM, Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM., Free PMC Articles: PMC3834829, PMC3834829 | 09/23/2013 |
| Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires an F/YSXXLXXL/Y motif. Interactions of NSD1 with liganded NRs require an overlapping LXXLL motif. | A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM, Chan CM, Fulton J, Montiel-Duarte C, Collins HM, Bharti N, Wadelin FR, Moran PM, Mongan NP, Heery DM., Free PMC Articles: PMC3834829, PMC3834829 | 09/24/2013 |
| No mutations in the NR2E1 gene were found in aniridia patients. | Absence of NR2E1 mutations in patients with aniridia.
Corso-Díaz X, Borrie AE, Bonaguro R, Schuetz JM, Rosenberg T, Jensen H, Brooks BP, Macdonald IM, Pasutto F, Walter MA, Grønskov K, Brooks-Wilson A, Simpson EM., Free PMC Article | 05/18/2013 |
| Enriched expression of TLX in higher-grade human gliomas is observed. | The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.
Zou Y, Niu W, Qin S, Downes M, Burns DK, Zhang CL., Free PMC Article | 01/26/2013 |
| BCL11A is a novel TLX coregulator that might be involved in TLX-dependent gene regulation in the brain. | The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function.
Estruch SB, Buzón V, Carbó LR, Schorova L, Lüders J, Estébanez-Perpiñá E., Free PMC Article | 10/13/2012 |
| Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1. | Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.
Schmouth JF, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt RA, Gregory-Evans K, Wasserman WW, Simpson EM., Free PMC Article | 04/28/2012 |
| Transgenic TLX acts as an essential regulator that ensures the proliferative ability of postnatal neural stem cells by controlling their activation through genetic interaction with p53 and other signaling pathways. | Activation of postnatal neural stem cells requires nuclear receptor TLX.
Niu W, Zou Y, Shen C, Zhang CL., Free PMC Article | 11/26/2011 |