| METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer. | METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer.
Cui Y, Pu M, Gong Y, Li R, Wang X, Ye J, Huang H, Liao D, Yang Y, Yin A, Li J, Deng Y, Tian Z, Pu R. | 10/25/2024 |
| Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3. | Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3.
Hu M, Dai C, Sun X, Chen Y, Xu N, Lin Z, Xu S, Cheng C, Tan Z, Bian S, Zheng W. | 02/28/2024 |
| BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1. | BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1.
Wang P, Sun J, Sun C, Zhao H, Zhang Y, Chen J., Free PMC Article | 06/30/2023 |
| BTF3-mediated regulation of BMI1 promotes colorectal cancer through influencing epithelial-mesenchymal transition and stem cell-like traits. | BTF3-mediated regulation of BMI1 promotes colorectal cancer through influencing epithelial-mesenchymal transition and stem cell-like traits.
Zhou W, Yun Z, Wang T, Li C, Zhang J. | 01/8/2022 |
| BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C. | BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C.
Zhang Y, Gao X, Yi J, Sang X, Dai Z, Tao Z, Wang M, Shen L, Jia Y, Xie D, Cheng H, Liu Z, Liu P., Free PMC Article | 10/2/2021 |
| miR802 inhibits the epithelialmesenchymal transition, migration and invasion of cervical cancer by regulating BTF3. | miR‑802 inhibits the epithelial‑mesenchymal transition, migration and invasion of cervical cancer by regulating BTF3.
Wu X, Liu L, Zhang H., Free PMC Article | 04/24/2021 |
| BTF3 promotes stemness and inhibits TypeInterferon signaling pathway in triple-negative breast cancer. | BTF3 promotes stemness and inhibits TypeⅠInterferon signaling pathway in triple-negative breast cancer.
Wang H, Gao L, Qi M, Su P, Xiong X, Zhao J, Hu J, Han B. | 04/24/2021 |
| BTF3 is positively related to CRC and BTF3-siRNA attenuated the tumorigenicity of colorectal cancer cells via MAD2L2, MCM3 and PLK1 activity reduction. | Positive expression of basic transcription factor 3 predicts poor survival of colorectal cancer patients: possible mechanisms involved.
Liu Q, Wu J, Lu T, Fang Z, Huang Z, Lu S, Dai C, Li M., Free PMC Article | 07/18/2020 |
| Expression of BTF3 is upregulated in hypopharyngeal squamous cell carcinoma and this upregulation is positively correlated with lymph node metastasis of this malignancy. | Upregulation of BTF3 affects the proliferation, apoptosis, and cell cycle regulation in hypopharyngeal squamous cell carcinoma.
Zhang Y, Gross N, Li Z, Yin G, Zhong Q, Liu C, Huang Z. | 02/15/2020 |
| Study showed that BTF3 is overexpressed in prostate cancer (PCa) tissues and correlates with stem-like traits. Cancer stem-like characteristics in PCa including self-renewal and metastatic potential were impaired by BTF3 loss. BTF3 could stabilize BMI1, a crucial regulator of prostate stem cell self-renewal. More importantly, data revealed that BTF3 is highly predictive of poor prognosis. | BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1.
Hu J, Sun F, Chen W, Zhang J, Zhang T, Qi M, Feng T, Liu H, Li X, Xing Y, Xiong X, Shi B, Zhou G, Han B., Free PMC Article | 11/30/2019 |
| TCGA analysis reveals high expression levels of BTF3 in luminal/ER + breast cancer and cell line models harboring ERalpha overexpression. Concordantly, BTF3 expression is highly and strongly associated with ESR1 expression in multiple breast cancer cohorts. | Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα.
Ding J, Wang X, Zhang Y, Sang X, Yi J, Liu C, Liu Z, Wang M, Zhang N, Xue Y, Shen L, Zhao W, Luo F, Liu P, Cheng H. | 10/12/2019 |
| Findings provide a novel understanding of the mechanism of gastric cancer and highlight the important role of BTF3/FOXM1 in tumor growth and BTF3/JAK2/STAT3 in EMT and metastasis | Basic Transcription Factor 3 Is Required for Proliferation and Epithelial-Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer.
Zhang DZ, Chen BH, Zhang LF, Cheng MK, Fang XJ, Wu XJ., Free PMC Article | 03/3/2018 |
| BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue | Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue.
Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Masters JR, Ahmed A., Free PMC Article | 09/6/2014 |
| may have a functional role in protecting against caries | Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries.
Shimizu T, Deeley K, Briseño-Ruiz J, Faraco IM Jr, Poletta FA, Brancher JA, Pecharki GD, Küchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Yildirim M, Mereb JC, Resick JM, Brandon CA, Cooper ME, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Orioli IM, Castilla EE, Marazita ML, Vieira AR., Free PMC Article | 03/15/2014 |
| BTF3 expression is associated with enhanced cell proliferation, reduced cell cycle regulation and apoptosis and its silencing decreased colony forming and proliferation of gastric cancer cells. | Basic transcription factor 3 is involved in gastric cancer development and progression.
Liu Q, Zhou JP, Li B, Huang ZC, Dong HY, Li GY, Zhou K, Nie SL., Free PMC Article | 01/18/2014 |
| BTF3 overexpression may be an early event in colorectal cancer development and could be useful biomarker for the early stage of colorectal cancers (CRC); BTF3 has positive correlations with NF-kappaB, RAD50, MRE11, NBS1 and AEG-1 and might influence complex signal pathways in CRC | Clinicopathological significance of BTF3 expression in colorectal cancer.
Wang CJ, Frånbergh-Karlson H, Wang DW, Arbman G, Zhang H, Sun XF. | 09/28/2013 |
| BTF3 interacts with ERalpha that has been activated either by 17beta-estradiol (ligand-dependent activation) or by epidermal growth factor (ligand-independent activation). | Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha.
Green CD, Thompson PD, Johnston PG, El-Tanani MK. | 01/21/2010 |
| BTF3 is overexpressed in pancreatic ductal adenocarcinoma , where it acts as a transcriptional regulator rather than a direct modulator of apoptosis. | Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells.
Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J. | 01/21/2010 |
| In addition to RNA polymerase II (otherwise RNA pol II, RNA polymerase B), four general transcription factors are required for initiation of transcription: BTF1 (also referred to as TFIID) which has recently been cloned from yeast, BTF2, BTF3 and STF. | Sequencing and expression of complementary DNA for the general transcription factor BTF3.
Zheng XM, Black D, Chambon P, Egly JM. | 11/10/2005 |