| Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. | Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.
Noura M, Matsuo H, Yasuda T, Tsuzuki S, Kiyoi H, Hayakawa F. | 02/5/2024 |
| TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer. | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.
Smith C, Goyal A, Weichenhan D, Allemand E, Mayakonda A, Toprak U, Riedel A, Balducci E, Manojkumar M, Pejkovska A, Mücke O, Sollier E, Bakr A, Breuer K, Lutsik P, Hermine O, Spicuglia S, Asnafi V, Plass C, Touzart A., Free PMC Article | 05/5/2023 |
| Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. | Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells.
Thoms JAI, Truong P, Subramanian S, Knezevic K, Harvey G, Huang Y, Seneviratne JA, Carter DR, Joshi S, Skhinas J, Chacon D, Shah A, de Jong I, Beck D, Göttgens B, Larsson J, Wong JWH, Zanini F, Pimanda JE. | 12/11/2021 |
| Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL). | Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).
Shaw TI, Dong L, Tian L, Qian C, Liu Y, Ju B, High A, Kavdia K, Pagala VR, Shaner B, Pei D, Easton J, Janke LJ, Porter SN, Ma X, Cheng C, Pruett-Miller SM, Choi J, Yu J, Peng J, Gu W, Look AT, Downing JR, Zhang J., Free PMC Article | 12/11/2021 |
| MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia. | MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia.
Sun H, Zhang Z, Luo W, Liu J, Lou Y, Xia S., Free PMC Article | 11/27/2021 |
| SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome. | SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.
Laukkanen S, Oksa L, Nikkilä A, Lahnalampi M, Parikka M, Seki M, Takita J, Degerman S, de Bock CE, Heinäniemi M, Lohi O. | 05/8/2021 |
| Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1. | Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1.
Banerjee A, Tripathi A, Duggal S, Banerjee A, Vrati S., Free PMC Article | 04/24/2021 |
| The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis. | The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis.
Meyer A, Herkt S, Kunze-Schumacher H, Kohrs N, Ringleb J, Schneider L, Kuvardina ON, Oellerich T, Häupl B, Krueger A, Seifried E, Bonig H, Lausen J., Free PMC Article | 03/28/2021 |
| The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2. | The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2.
Siegwart LC, Schwemmers S, Wehrle J, Koellerer C, Seeger T, Gründer A, Pahl HL. | 12/12/2020 |
| among the many factors wired within this complex regulatory network, ETV2, SCL and RUNX1 are the central components. All three factors are absolutely required for blood cell generation, each one controlling a precise step of specification from the mesoderm germ layer to fully functional blood progenitors | Transcriptional control of blood cell emergence.
Menegatti S, de Kruijf M, Garcia-Alegria E, Lacaud G, Kouskoff V., Free PMC Article | 06/20/2020 |
| Manipulation of CTCF boundary can alter TAL1 TAD and oncogenic transcription networks in leukemogenesis. | Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.
Li Y, Liao Z, Luo H, Benyoucef A, Kang Y, Lai Q, Dovat S, Miller B, Chepelev I, Li Y, Zhao K, Brand M, Huang S., Free PMC Article | 05/23/2020 |
| Data indicate a T-cell acute lymphocytic leukaemia 1 (TAL1) /FUSE binding protein 1 (FUBP1) transcriptional relationship, whose physiological function in haematopoiesis is connected to proper erythropoiesis. | FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation.
Steiner M, Schneider L, Yillah J, Gerlach K, Kuvardina ON, Meyer A, Maring A, Bonig H, Seifried E, Zörnig M, Lausen J., Free PMC Article | 11/23/2019 |
| the forward programming of human pluripotent stem cells through overexpression of GATA1, FLI1, and TAL1 leads to the production of a population of progenitors that can differentiate into megakaryocyte or erythroblasts. | Transcription Factor Levels after Forward Programming of Human Pluripotent Stem Cells with GATA1, FLI1, and TAL1 Determine Megakaryocyte versus Erythroid Cell Fate Decision.
Dalby A, Ballester-Beltrán J, Lincetto C, Mueller A, Foad N, Evans A, Baye J, Turro E, Moreau T, Tijssen MR, Ghevaert C., Free PMC Article | 09/21/2019 |
| Which was expressed in normal thymocytes but repressed in TAL1-positive T-ALL cells. | Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.
Ngoc PCT, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG, Sanda T., Free PMC Article | 06/15/2019 |
| suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-cell acute lymphoblastic leukaemia | Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
Gustafsson BM, Mattsson K, Bogdanovic G, Leijonhufvud G, Honkaniemi E, Ramme K, Ford AM. | 05/25/2019 |
| TAL1 acts as a downstream gene mediating the function of MEIS2 during early hematopoiesis. | MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1.
Wang M, Wang H, Wen Y, Chen X, Liu X, Gao J, Su P, Xu Y, Zhou W, Shi L, Zhou J., Free PMC Article | 04/20/2019 |
| discuss the transcriptional regulatory network and downstream target genes, including protein-coding genes and non-coding RNAs, controlled by TAL1 in normal hematopoiesis and T-cell leukemogenesis. | Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia.
Tan TK, Zhang C, Sanda T. | 02/9/2019 |
| TAL1 mediates the function of MEIS1 in hemogenic endothelial progenitors specification. In addition, MEIS1 is vital for megakaryopoiesis and thrombopoiesis from hPSCs. Mechanistically, FLI1 acts as a downstream gene necessary for the function of MEIS1 during megakaryopoiesis | MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Wang H, Liu C, Liu X, Wang M, Wu D, Gao J, Su P, Nakahata T, Zhou W, Xu Y, Shi L, Ma F, Zhou J., Free PMC Article | 01/19/2019 |
| HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. | Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE., Free PMC Article | 04/28/2018 |
| NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR | Erythroid activator NF-E2, TAL1 and KLF1 play roles in forming the LCR HSs in the human adult β-globin locus.
Kim YW, Yun WJ, Kim A. | 09/30/2017 |
| mutations of SF3B1 may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1 | Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.
Jin S, Su H, Tran NT, Song J, Lu SS, Li Y, Huang S, Abdel-Wahab O, Liu Y, Zhao X., Free PMC Article | 09/9/2017 |
| a novel role of FOXP3 as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity. | FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.
Fleskens V, Mokry M, van der Leun AM, Huppelschoten S, Pals CE, Peeters J, Coenen S, Cardoso BA, Barata JT, van Loosdregt J, Coffer PJ. | 09/2/2017 |
| Review emphasizes recent findings that shed light into the intricacies of TAL1 (epi)genetic regulation and the transcription network orchestrated by this major T-cell oncogene.[reiew] | Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.
Correia NC, Arcangeli ML, Pflumio F, Barata JT. | 08/12/2017 |
| Deletions of TAL1 is associated with acute T-lymphoblastic leukemia. | Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K. | 07/22/2017 |
| SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. | SCL/TAL1: a multifaceted regulator from blood development to disease.
Porcher C, Chagraoui H, Kristiansen MS. | 04/29/2017 |