| Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors. | Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.
Madsen JJ, Petersen JE, Christensen DP, Hansen JB, Schwartz TW, Frimurer TM, Olsen OH., Free PMC Article | 01/3/2024 |
| IFN-alpha/beta-mediated NK2R expression is related to the malignancy of colon cancer cells. | IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells.
Xiang H, Toyoshima Y, Shen W, Wang X, Okada N, Kii S, Sugiyama K, Nagato T, Kobayashi H, Ikeo K, Hashimoto S, Tanino M, Taketomi A, Kitamura H., Free PMC Article | 08/13/2022 |
| Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK1 and NK2 tachykinin receptors. | Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.
Dai L, Perera DS, Burcher E, Liu L. | 06/5/2021 |
| This study revealed for the first time an increase of Mast Cells -nerve association and NK2R expression on Mast Cells during Allergic Rhinitis as well as nerve fibres containing receptors for mass cells. | Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis.
Le DD, Schmit D, Heck S, Omlor AJ, Sester M, Herr C, Schick B, Daubeuf F, Fähndrich S, Bals R, Frossard N, Al Kadah B, Dinh QT. | 02/10/2018 |
| expressed in mural granulosa and cumulus cells | Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
García-Ortega J, Pinto FM, Prados N, Bello AR, Almeida TA, Fernández-Sánchez M, Candenas L. | 07/8/2017 |
| Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata. | Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.
González-Santana A, Marrero-Hernández S, Dorta I, Hernández M, Pinto FM, Báez D, Bello AR, Candenas L, Almeida TA. | 06/10/2017 |
| Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells | Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells.
Ohtake J, Kaneumi S, Tanino M, Kishikawa T, Terada S, Sumida K, Masuko K, Ohno Y, Kita T, Iwabuchi S, Shinohara T, Tanino Y, Takemura T, Tanaka S, Kobayashi H, Kitamura H. | 05/7/2016 |
| The occurrence of a profound alteration in NK receptor expression in RMDD is a novel finding that suggests NK-1R and NK-2R pathways as possible players in major depressive disorder. | Recurrent major depressive disorder: Imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes.
Bardelli C, Amoruso A, Manzetti E, Fresu LG, Valsesia R, Zeppegno P, Brunelleschi S. | 06/22/2013 |
| This study aims to explore the associations of polymorphisms in tachykinin, precursor 1 (TAC1), tachykinin receptor 1 (TACR1), and tachykinin receptor 2 (TACR2) genes and their interactions with the risk of colorectal cancer among Chinese population. | Association of genetic variants in tachykinins pathway genes with colorectal cancer risk.
Yu Y, Pan Y, Jin M, Zhang M, Zhang S, Li Q, Jiang X, Liu H, Guo J, Liu H, Chen K. | 03/23/2013 |
| NK2R-dependent neuropeptide signaling regulates Ag-specific T cell responses via activation of DC function | Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Kitamura H, Kobayashi M, Wakita D, Nishimura T. | 06/16/2012 |
| This study demonistrated that no association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. | No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.
Friedrich P, Feulner TM, Laws SM, Eckart K, Perneczky R, Kurz A, Förstl H, Riemenschneider M, Friedrich P, Feulner TM, Laws SM, Eckart K, Perneczky R, Kurz A, Förstl H, Riemenschneider M. | 07/23/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesPharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment.
Ye YM, Lee HY, Kim SH, Jee YK, Lee SK, Lee SH, Park HS. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough.
Kim TB, Oh SY, Park HK, Jeon SG, Chang YS, Lee KY, Cho YS, Chae IH, Kim YK, Cho SH, Moon HB, Min KU, Kim YY. | 08/12/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R. | 03/25/2009 |
| The prevalence of the TACR2 mRNA alpha isoform strongly suggests a major involvement of tachykinin NK(2) receptor in the regulation of human colonic functions. | Expression of the tachykinin receptor mRNAs in healthy human colon.
Jaafari N, Hua G, Adélaïde J, Julé Y, Imbert J. | 01/21/2010 |
| polymorphisms leading to the Ile23Thr and Arg375His amino acid exchanges are highly prevalent in the human TACR2 gene, but do affect the potency of the endogenous agonist NKA or small molecule antagonists with respect to intracellular Ca(2+) signalling | Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants.
Ahlstedt I, Engberg S, Smith J, Perrey C, Moody A, Morten J, Lagerström-Fermér M, Drmota T, von Mentzer B, Påhlman I, Lindström E. | 01/21/2010 |
| all three subtypes of NKRs are expressed in native human airway smooth muscle cells & IP3 levels are the primary mediators of NKR-stimulated initial [Ca2+]i increases, whereas store-operated Ca2+ channels mediate sustained phase of the [Ca2+]i increase. | Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
Mizuta K, Gallos G, Zhu D, Mizuta F, Goubaeva F, Xu D, Panettieri RA Jr, Yang J, Emala CW Sr., Free PMC Article | 01/21/2010 |
| NK2 receptors are involved in the neuroneuronal and neuromuscular processes regulating human colonic motility. | Qualitative and quantitative analysis of tachykinin NK2 receptors in chemically defined human colonic neuronal pathways.
Jaafari N, Khomitch-Baud A, Gilhodes JC, Hua G, Julé Y. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesInterleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R. No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.
Friedrich P, Feulner TM, Laws SM, Eckart K, Perneczky R, Kurz A, Förstl H, Riemenschneider M, Friedrich P, Feulner TM, Laws SM, Eckart K, Perneczky R, Kurz A, Förstl H, Riemenschneider M. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B. Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation.
Garcia-Barcelo M, King SK, Miao X, So MT, Holden WT, Moore JH, Sutcliffe JR, Hutson JM, Tam PK. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough.
Park HK, Oh SY, Kim TB, Bahn JW, Shin ES, Lee JE, Oh HB, Kim YK, Park T, Cho SH, Min KU, Kim YY. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 03/13/2008 |
| Increased proportion of alveolar macrophages expressing neurokinin 2 receptor may be involved in the pathogenesis of COPD. | Increased neurokinin-2 receptor expression in alveolar macrophages of smokers with COPD.
Miotto D, Boschetto P, Cavallesco G, Zeni E, Querzoli P, Pedriali M, Chiarelli S, Fabbri LM, Mapp CE. | 01/21/2010 |
| Data indicate that presynaptic and postsynaptic neuroneuronal and neuromuscular regulatory processes mediated by tachykinins via NK2r may occur for modulating human colonic motility. | Distribution pattern of tachykinin NK2 receptors in human colon: involvement in the regulation of intestinal motility.
Jaafari N, Khomitch-Baud A, Christen MO, Julé Y. | 01/21/2010 |
| protease-activated receptor 2 agonists induced a contraction of murine intestinal smooth muscle that was mediated by nerves and requires both neurokinin 1 and 2 receptors | PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Zhao A, Shea-Donohue T. | 01/21/2010 |
| NK2 receptors are compartmentalized at the plasma membrane | Dynamic confinement of NK2 receptors in the plasma membrane. Improved FRAP analysis and biological relevance.
Cézanne L, Lecat S, Lagane B, Millot C, Vollmer JY, Matthes H, Galzi JL, Lopez A. | 01/21/2010 |
| Identification of a tachykinin NK(2) receptor splice variant. | Identification of a tachykinin NK(2) receptor splice variant and its expression in human and rat tissues.
Candenas ML, Cintado CG, Pennefather JN, Pereda MT, Loizaga JM, Maggi CA, Pinto FM. | 01/21/2010 |
| Tachykinin NK2 receptors mediate smooth muscle contraction in human corpus cavernosum and spongiosum. | Tachykinin NK1 and NK2 receptors mediate inhibitory vs excitatory motor responses in human isolated corpus cavernosum and spongiosum.
Patacchini R, Barbagli G, Palminteri E, Lazzeri M, Turini D, Maggi CA., Free PMC Article | 01/21/2010 |
| Preprotachykinin-I peptides mediate autocrine proliferation of the neuroblastoma cells through both NK-1 and NK-2 receptors. | Autocrine proliferation of neuroblastoma cells is partly mediated through neurokinin receptors: relevance to bone marrow metastasis.
Mukerji I, Ramkissoon SH, Reddy KK, Rameshwar P. | 01/21/2010 |