| Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface. | Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface.
Kioumourtzoglou D, Black HL, Al Tobi M, Livingstone R, Petrie JR, Boyle JG, Gould GW, Bryant NJ., Free PMC Article | 01/3/2024 |
| Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation. | Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation.
Gigon L, Fettrelet T, Miholic M, McLeish KR, Yousefi S, Stojkov D, Simon HU., Free PMC Article | 11/16/2023 |
| Syntaxin 4 is essential for hearing in human and zebrafish. | Syntaxin 4 is essential for hearing in human and zebrafish.
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM., Free PMC Article | 03/24/2023 |
| Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma. | Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma.
He L, Jiang H, Lai Z, Zhong Z, Huang Z., Free PMC Article | 10/23/2021 |
| Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition. | Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.
Perrotta C, Cervia D, Di Renzo I, Moscheni C, Bassi MT, Campana L, Martelli C, Catalani E, Giovarelli M, Zecchini S, Coazzoli M, Capobianco A, Ottobrini L, Lucignani G, Rosa P, Rovere-Querini P, De Palma C, Clementi E., Free PMC Article | 08/17/2019 |
| these results indicate that the activation of beta-ARs induces secretory granules and cell membrane fusion via the interaction of VAMP-2 and syntaxin-4 in a PKA- and F-actin-dependent manner in human submandibular gland. Up-regulated beta-ARs might participate in altering protein secretion in transplanted submandibular gland by promoting the interaction of VAMP-2 with syntaxin-4. | β-adrenoceptor activation increased VAMP-2 and syntaxin-4 in secretory granules are involved in protein secretion of submandibular gland through the PKA/F-actin pathway.
Ding C, Cong X, Zhang Y, Li SL, Wu LL, Yu GY., Free PMC Article | 08/18/2018 |
| Confocal immunofluorescence microscopy revealed a colocalization of syntaxin 4 with a MVB-specific marker, exosomes and hepatitis C virus (HCV) core, which suggests a fraction of syntaxin 4 is associated with exosomes loaded with HCV. Altogether, it is assumed that syntaxin 4 is a novel essential cellular factor for the release of HCV. | Identification of syntaxin 4 as an essential factor for the hepatitis C virus life cycle.
Ren H, Elgner F, Himmelsbach K, Akhras S, Jiang B, Medvedev R, Ploen D, Hildt E. | 06/9/2018 |
| The authors found that activation of dendritic cells by bacterial lipopolysaccharide leads to increased Forster resonance energy transfer-fluorescence of fluorescently labeled syntaxin 4 with VAMP3 specifically at the plasma membrane, indicating increased SNARE complex formation, whereas FRET with other tested SNAREs was unaltered. | Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activation.
Verboogen DRJ, González Mancha N, Ter Beest M, van den Bogaart G., Free PMC Article | 03/10/2018 |
| Data suggest MUNC18C is required for STX4-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 fragment binds to MUNC18C and inhibits interactions of STX4 with synaptosome-associated protein 23 (SNAP23) and vesicle-associated membrane protein 2 (VAMP2). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4) | Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.
Brasher MI, Martynowicz DM, Grafinger OR, Hucik A, Shanks-Skinner E, Uniacke J, Coppolino MG., Free PMC Article | 10/21/2017 |
| The analysis revealed three candidate genes GSK3B, PTPN1, STX4 that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2). | De-regulation of diabetic regulatory genes in psoriasis: Deciphering the unsolved riddle.
AlFadhli S, Al-Zufairi AAM, Nizam R, AlSaffar HA, Al-Mutairi N. | 01/28/2017 |
| When the expression of STX4 mRNA was inhibited with short or small interfering, or silencing, RNA in macrophages, the survival of Brucella melitensis was significantly reduced. | Blocking the expression of syntaxin 4 interferes with initial phagocytosis of Brucella melitensis in macrophages.
Castañeda-Ramírez A, González-Rodríguez D, Hernández-Pineda JA, Verdugo-Rodríguez A., Free PMC Article | 05/21/2016 |
| Syntaxin-4 has a role in mediating exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells | Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.
Xie L, Zhu D, Dolai S, Liang T, Qin T, Kang Y, Xie H, Huang YC, Gaisano HY. | 03/12/2016 |
| Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion. | SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.
Williams KC, McNeilly RE, Coppolino MG., Free PMC Article | 02/28/2015 |
| upregulation of Syntaxin 4 is sufficient to significantly improve insulin secretory function to human type 2 diabetes islets retaining low levels of residual function | Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.
Oh E, Stull ND, Mirmira RG, Thurmond DC., Free PMC Article | 07/12/2014 |
| STX4 is implicated in the antibody secretion. | Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells.
Gómez-Jaramillo L, Delgado-Pérez L, Reales E, Mora-López F, Mateos RM, García-Poley A, Brieva JA, Campos-Caro A. | 03/29/2014 |
| Syntaxin-4 plays a vital role in exocytosis of IgE from plasma cells. Knock-down of syntaxin-4, but not VAMP3 dramatically reduced IgE secretion from U266 plasma cells causing it to accumulate in the cell. | Syntaxin-4 is essential for IgE secretion by plasma cells.
Rahman A, Decourcey J, Larbi NB, Loughran ST, Walls D, Loscher CE. | 12/7/2013 |
| These results revealed, for the first time, the extracellular role of syntaxin4 and shed light on the division of the extracellular effects exerted by epimorphin and syntaxin4 on keratinocyte cornification. | The impact of extracellular syntaxin4 on HaCaT keratinocyte behavior.
Kadono N, Miyazaki T, Okugawa Y, Nakajima K, Hirai Y. | 04/7/2012 |
| siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells reduced cell surface expression of alpha5beta1 and alpha3beta1 integrins | Syntaxins 3 and 4 mediate vesicular trafficking of α5β1 and α3β1 integrins and cancer cell migration.
Day P, Riggs KA, Hasan N, Corbin D, Humphrey D, Hu C. | 01/14/2012 |
| Syntaxin 4 activation and insulin release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis | Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis.
Wiseman DA, Kalwat MA, Thurmond DC., Free PMC Article | 07/2/2011 |
| Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons. | Role of syntaxin 4 in activity-dependent exocytosis and synaptic plasticity in hippocampal neurons.
Mohanasundaram P, Shanmugam MM. | 01/29/2011 |
| Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. | Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
Perrotta C, Bizzozero L, Cazzato D, Morlacchi S, Assi E, Simbari F, Zhang Y, Gulbins E, Bassi MT, Rosa P, Clementi E., Free PMC Article | 01/15/2011 |
| dysferlin and syntaxin-4 similarly transit a common endosomal pathway in skeletal muscle cells. | Reduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathway.
Evesson FJ, Peat RA, Lek A, Brilot F, Lo HP, Dale RC, Parton RG, North KN, Cooper ST., Free PMC Article | 10/23/2010 |
| Stx4 defines an exocytic zone that directs membrane fusion for postsynaptic plasticity, revealing a novel specialization for local membrane traffic in dendritic spines. | Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines.
Kennedy MJ, Davison IG, Robinson CG, Ehlers MD., Free PMC Article | 05/10/2010 |
| syntaxin 4 is involved in the intracellular transport of MT1-MMP toward the plasma membrane | Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.
Miyata T, Ohnishi H, Suzuki J, Yoshikumi Y, Ohno H, Mashima H, Yasuda H, Ishijima T, Osawa H, Satoh K, Sunada K, Kita H, Yamamoto H, Sugano K. | 01/21/2010 |
| Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cells | Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.
Saito T, Okada S, Yamada E, Ohshima K, Shimizu H, Shimomura K, Sato M, Pessin JE, Mori M. | 01/21/2010 |