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    STAT6 signal transducer and activator of transcription 6 [ Homo sapiens (human) ]

    Gene ID: 6778, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases.

    STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases.
    Tolomeo M, Cascio A.

    11/4/2024
    The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters.

    The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters.
    de Juan A, Tabtim-On D, Coillard A, Becher B, Goudot C, Segura E.

    10/25/2024
    NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.

    NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.
    Eschbacher KL, Tran QT, Moskalev EA, Jenkins S, Fritchie K, Stoehr R, Caron A, Link MJ, Brown PD, Guajardo A, Brat DJ, Wu A, Santagata S, Louis DN, Brastianos PK, Kaplan AB, Alexander B, Rossi S, Ferrarese F, Raleigh DR, Nguyen MP, Gross J, Velazquez Vega J, Rodriguez F, Perry A, Martinez-Lage M, Orr BA, Haller F, Giannini C., Free PMC Article

    10/23/2024
    Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.

    Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.
    Deng C, Huo M, Chu H, Zhuang X, Deng G, Li W, Wei H, Zeng L, He Y, Liu H, Li J, Zhang C, Chen H., Free PMC Article

    03/13/2024
    STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment.

    STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment.
    Benoit A, Abraham MJ, Li S, Kim J, Estrada-Tejedor R, Bakadlag R, Subramaniam N, Makhani K, Guilbert C, Tu R, Salaciak M, Klein KO, Coyle KM, Hilton LK, Santiago R, Dmitrienko S, Assouline S, Morin RD, Del Rincon SV, Johnson NA, Mann KK., Free PMC Article

    03/11/2024
    Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.

    Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
    Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S., Free PMC Article

    02/29/2024
    Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond.

    Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond.
    STAT6 Gain-of-Function International Consortium. Electronic address: sturvey@bcchr.ca, STAT6 Gain-of-Function International Consortium.

    02/15/2024
    STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.

    STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
    Yuan T, Xia Y, Pan S, Li B, Ye Z, Yan X, Hu W, Li L, Song B, Yu W, Li H, Rao T, Lin F, Zhou X, Cheng F.

    11/30/2023
    Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma.

    Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma.
    Minskaia E, Maimaris J, Jenkins P, Albuquerque AS, Hong Y, Eleftheriou D, Gilmour KC, Grace R, Moreira F, Grimbacher B, NIHR Bioresource-Rare Diseases Consortium, Morris EC, Burns SO., Free PMC Article

    09/15/2023
    Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.

    Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
    Hou Y, Zheng S, Zou F, Wang D, Da H, Zhou Y, Fan X, Liu J, Zhao H, He J, Li H, Sun X, Liu Y.

    08/30/2023
    LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.

    LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
    Li Y, Guo J, Zhang H, Li Z, Ren Y, Jiang Y, Liu X, Hu X., Free PMC Article

    07/24/2023
    Learning while treating: Gain-of-function STAT6 variants in severe allergic disease.

    Learning while treating: Gain-of-function STAT6 variants in severe allergic disease.
    Smith TD, Doherty TA., Free PMC Article

    06/7/2023
    Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation.

    Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T(H)9 cells to promote allergic inflammation.
    Son A, Meylan F, Gomez-Rodriguez J, Kaul Z, Sylvester M, Falduto GH, Vazquez E, Haque T, Kitakule MM, Wang C, Manthiram K, Qi CF, Cheng J, Gurram RK, Zhu J, Schwartzberg P, Milner JD, Frischmeyer-Guerrerio PA, Schwartz DM., Free PMC Article

    06/5/2023
    ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.

    ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.
    Kochanowsky JA, Chandrasekaran S, Sanchez JR, Thomas KK, Koshy AA., Free PMC Article

    05/8/2023
    Signal Transducer and Activator of Transcription 6 Changes and Protein Frustration by Single Amino Acid Substitutions: Implications for Cancer Progression.

    Signal Transducer and Activator of Transcription 6 Changes and Protein Frustration by Single Amino Acid Substitutions: Implications for Cancer Progression.
    Alharethi SH, Kamal T, Alharbi B, Alhassan HH, Hakami MA, Alotaibi BS, Rub MA, Marwani HM, Alamry KA, Asiri AM, Azum N.

    04/14/2023
    Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling.

    Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling.
    Brusilovsky M, Rochman M, Shoda T, Kotliar M, Caldwell JM, Mack LE, Besse JA, Chen X, Weirauch MT, Barski A, Rothenberg ME., Free PMC Article

    04/7/2023
    IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.

    IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
    Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q., Free PMC Article

    03/24/2023
    Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.

    Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
    Sharma M, Leung D, Momenilandi M, Jones LCW, Pacillo L, James AE, Murrell JR, Delafontaine S, Maimaris J, Vaseghi-Shanjani M, Del Bel KL, Lu HY, Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO, Meyts I, Casanova JL, Lyons JJ, Parvaneh N, Nguyen ATV, Cancrini C, Heimall J, Ahmed H, McKinnon ML, Lau YL, BĂ©ziat V, Turvey SE., Free PMC Article

    03/10/2023
    A germline STAT6 gain-of-function variant is associated with early-onset allergies.

    A germline STAT6 gain-of-function variant is associated with early-onset allergies.
    Suratannon N, Ittiwut C, Dik WA, Ittiwut R, Meesilpavikkai K, Israsena N, Ingrungruanglert P, Dalm VASH, van Daele PLA, Sanpavat A, Chaijitraruch N, Schrijver B, Buranapraditkun S, Porntaveetus T, Swagemakers SMA, IJspeert H, Palaga T, Suphapeetiporn K, van der Spek PJ, Hirankarn N, Chatchatee P, Martin van Hagen P, Shotelersuk V.

    02/11/2023
    Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle.

    Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle.
    Shirakura T, Yamada Y, Nakata S, Asayama B, Seo Y, Tanikawa S, Kato T, Komoribayashi N, Kubo N, Monma N, Okura N, Tanaka S, Oda Y, Hirato J, Yokoo H, Nobusawa S.

    01/11/2023
    SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21.

    SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21.
    Yu D, Zhao Z, Wang L, Qiao S, Yang Z, Wen Q, Zhu G., Free PMC Article

    11/12/2022
    Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities?

    Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities?
    Stevens TM, Rooper LM, Bacchi CE, Fernandes IL, Antonescu CR, Gagan J, Bishop JA., Free PMC Article

    09/3/2022
    Patterns of Inflammatory Cell Infiltration and Expression of STAT6 in the Lungs of Patients With COVID-19: An Autopsy Study.

    Patterns of Inflammatory Cell Infiltration and Expression of STAT6 in the Lungs of Patients With COVID-19: An Autopsy Study.
    Cao W, Birkenbach M, Chen S., Free PMC Article

    05/14/2022
    STAT6 is not expressed in Kaposi sarcoma.

    STAT6 is not expressed in Kaposi sarcoma.
    Karpathiou G, Habougit C, Peoc'h M.

    03/19/2022
    REPORT-Association analysis of STAT6 SNP with asthma in Pakistani population.

    REPORT-Association analysis of STAT6 SNP with asthma in Pakistani population.
    Riaz A, Akhter Z, Iqbal M, Ahsan Riaz M.

    02/5/2022
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