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    BRAF B-Raf proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 673, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.

    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
    Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, Rauch J, Kolch W, von Kriegsheim A, Dorotikova A, Andrysik Z, Vichova R, Vacek O, Soucek K, Uldrijan S., Free PMC Article

    10/30/2024
    Follicular cell-derived thyroid carcinomas harboring novel genetic BRAF[NON-V600E] mutations: real-world data obtained using a multigene panel.

    Follicular cell-derived thyroid carcinomas harboring novel genetic BRAF(NON-V600E) mutations: real-world data obtained using a multigene panel.
    von Ammon JL, Machado GJR, da Matta RRC, Telles AC, Carrijo F, Dos Santos BAF, Brandão JCD, da Silva TM, Hecht F, Colozza-Gama GA, Tezzei JH, Cerutti JM, Ramos HE., Free PMC Article

    10/22/2024
    A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC.

    A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC.
    Liu D, Ding K, Yin K, Peng Z, Li X, Pan Y, Jin X, Xu Y., Free PMC Article

    10/10/2024
    BRAF mutation in myeloid neoplasm: incidences and clinical outcomes.

    BRAF mutation in myeloid neoplasm: incidences and clinical outcomes.
    Abuasab T, Mohamed S, Pemmaraju N, Kadia TM, Daver N, DiNardo CD, Ravandi F, Qiao W, Montalban-Bravo G, Borthakur G.

    09/11/2024
    Decoding the Molecular Mechanisms of BRAF [V600E]-Induced Nevi Formation.

    Decoding the Molecular Mechanisms of BRAF (V600E)-Induced Nevi Formation.
    Liang WZ, Liu YX, Xu DD, Jiang WJ, Ran RS.

    09/9/2024
    Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman.

    Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman.
    Al Ghafri A, Sayed SG, Al Badi S, Al Rashdi A, Al Husaini S, Qureshi A, Shalaby A., Free PMC Article

    09/6/2024
    Non-canonical BRAF variants and rearrangements in hairy cell leukemia.

    Non-canonical BRAF variants and rearrangements in hairy cell leukemia.
    Langabeer SE., Free PMC Article

    09/4/2024
    Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).

    Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).
    Booker BD, Markt SC, Schumacher FR, Rose J, Cooper G, Selfridge JE, Koroukian SM.

    08/30/2024
    Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond.

    Heterogeneous pathogenesis of melanoma: BRAF mutations and beyond.
    Colombino M, Casula M, Paliogiannis P, Manca A, Sini MC, Pisano M, Santeufemia DA, Cossu A, Palmieri G.

    08/22/2024
    RICTOR/mTORC2 downregulation in BRAF[V600E] melanoma cells promotes resistance to BRAF/MEK inhibition.

    RICTOR/mTORC2 downregulation in BRAF(V600E) melanoma cells promotes resistance to BRAF/MEK inhibition.
    Ponzone L, Audrito V, Landi C, Moiso E, Levra Levron C, Ferrua S, Savino A, Vitale N, Gasparrini M, Avalle L, Vantaggiato L, Shaba E, Tassone B, Saoncella S, Orso F, Viavattene D, Marina E, Fiorilla I, Burrone G, Abili Y, Altruda F, Bini L, Deaglio S, Defilippi P, Menga A, Poli V, Porporato PE, Provero P, Raffaelli N, Riganti C, Taverna D, Cavallo F, Calautti E., Free PMC Article

    08/15/2024
    Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.

    Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
    Zhang Z, Wu Y, Fu J, Yu X, Su Y, Jia S, Cheng H, Shen Y, He X, Ren K, Zheng X, Guan H, Rao F, Zhao L., Free PMC Article

    08/8/2024
    Unraveling morphology, methylation profiling, and diagnostic challenges in BRAF-Mutant pediatric glial and glioneuronal tumors.

    Unraveling morphology, methylation profiling, and diagnostic challenges in BRAF-Mutant pediatric glial and glioneuronal tumors.
    Alturkustani M., Free PMC Article

    08/5/2024
    KRAS and BRAF genetic alterations in lung cancer: A case - control study.

    KRAS and BRAF genetic alterations in lung cancer: A case - control study.
    Sawal HA, Shah SI, Malik SS, Mehmood S, Baig M, Rasool E, Masood N.

    08/5/2024
    High levels of soluble CD73 unveil resistance to BRAF inhibitors in melanoma cells.

    High levels of soluble CD73 unveil resistance to BRAF inhibitors in melanoma cells.
    Giraulo C, Orlando L, Morretta E, Voli A, Plaitano P, Cicala C, Potaptschuk E, Müller CE, Tosco A, Monti MC, Morello S.

    08/3/2024
    Association of BRAF or TERT Promoter Mutations and Advanced Papillary Thyroid Carcinoma.

    Association of BRAF or TERT Promoter Mutations and Advanced Papillary Thyroid Carcinoma.
    Toda S, Saito N, Kadoya M, Okubo Y, Yamazaki H, Suganuma N, Iwasaki H, Masudo K, Hoshino D.

    07/16/2024
    Lymph Node Metastasis in Papillary Thyroid Carcinoma, A Study of BRAF V600E and TERT Promoter Mutations.

    Lymph Node Metastasis in Papillary Thyroid Carcinoma, A Study of BRAF V600E and TERT Promoter Mutations.
    Soeratman AR, Kartini D, Andinata B, Harahap AS, Sudarsono NC., Free PMC Article

    07/15/2024
    The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules.

    The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules.
    Lin Y, Cheng Y, Zhang Y, Ren X, Li J, Shi H, Li Y, Luo Y, Wang H.

    07/9/2024
    Spectrum and Frequency of BRAF Mutations in Skin Melanomas in the Dalmatian Region of Croatia.

    Spectrum and Frequency of BRAF Mutations in Skin Melanomas in the Dalmatian Region of Croatia.
    Bezić J, Tomić I, Pavić M.

    07/5/2024
    Associations of BRAF[V600E] mutation with the American College of Radiology Thyroid Imaging Reporting and Data System and clinicopathological characteristics in pediatric patients with papillary thyroid carcinoma.

    Associations of BRAF(V600E) mutation with the American College of Radiology Thyroid Imaging Reporting and Data System and clinicopathological characteristics in pediatric patients with papillary thyroid carcinoma.
    Tan Y, Zhong J, Zheng T, Fu Y, Liu M, Wang G.

    07/2/2024
    BRAF Mutations in Patients with Myeloid Neoplasms: A Cancer Center Multigene Next-Generation Sequencing Analysis Experience.

    BRAF Mutations in Patients with Myeloid Neoplasms: A Cancer Center Multigene Next-Generation Sequencing Analysis Experience.
    Fei F, Caporale C, Chang L, Fortini BK, Ali H, Bell D, Stein A, Marcucci G, Telatar M, Afkhami M., Free PMC Article

    07/2/2024
    KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients.

    KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients.
    El Zaitouni S, Laraqui A, Ghaouti M, Benzekri A, Kettani F, Bajjou T, Sekhsokh Y, Benmokhtar S, Jafari M, Baba W, Oukabli M, El Annaz H, Abi R, Tagajdid MR, El Kochri S, Lahlou IA, Ameziane El Hassani R, Ennibi K., Free PMC Article

    06/28/2024
    Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.

    Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.
    Li X, Chi X, Huang P, Liang Q, Liu J.

    06/10/2024
    Genetic trio of BRAF and TERT alterations and rs2853669TT in papillary thyroid cancer aggressiveness.

    Genetic trio of BRAF and TERT alterations and rs2853669TT in papillary thyroid cancer aggressiveness.
    Liu R, Zhu G, Tan J, Shen X, Xing M., Free PMC Article

    06/5/2024
    Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma.

    Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma.
    Aya F, Lanuza-Gracia P, González-Pérez A, Bonnal S, Mancini E, López-Bigas N, Arance A, Valcárcel J.

    05/10/2024
    Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study.

    Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study.
    Kim C, Agarwal S, Bychkov A, Hang JF, Harahap AS, Hirokawa M, Kakudo K, Keelawat S, Liu CY, Liu Z, Nguyen TP, Rana C, Vuong HG, Zhu Y, Jung CK.

    05/3/2024
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