| Star-PAP controls oncogene expression through primary miRNA 3'-end formation to regulate cellular proliferation and tumour formation. | Star-PAP controls oncogene expression through primary miRNA 3'-end formation to regulate cellular proliferation and tumour formation.
Mohanan NK, Shaji F, Sudheesh AP, Bangalore Prabhashankar A, Sundaresan NR, Laishram RS. | 04/16/2024 |
| Mechanism of U6 snRNA oligouridylation by human TUT1. | Mechanism of U6 snRNA oligouridylation by human TUT1.
Yamashita S, Tomita K., Free PMC Article | 08/16/2023 |
| Star-PAP RNA Binding Landscape Reveals Novel Role of Star-PAP in mRNA Metabolism That Requires RBM10-RNA Association. | Star-PAP RNA Binding Landscape Reveals Novel Role of Star-PAP in mRNA Metabolism That Requires RBM10-RNA Association.
Koshre GR, Shaji F, Mohanan NK, Mohan N, Ali J, Laishram RS., Free PMC Article | 10/23/2021 |
| Crystallographic and biochemical studies of TUT1 revealed the molecular mechanism underlying the specific oligo-uridylylation of the 3'-end of U6 snRNA by TUT1. | Crystal structures of U6 snRNA-specific terminal uridylyltransferase.
Yamashita S, Takagi Y, Nagaike T, Tomita K., Free PMC Article | 12/22/2018 |
| KLHL7 is a novel regulator of the nucleolus associated with TUT1 ubiquitination, and pathogenic KLHL7 mutants may provide valuable information to elucidate a mechanism of retinitis pigmentosa etiology. | KLHL7 promotes TUT1 ubiquitination associated with nucleolar integrity: Implications for retinitis pigmentosa.
Kim J, Tsuruta F, Okajima T, Yano S, Sato B, Chiba T. | 11/26/2017 |
| Star-PAP possesses tumor-suppressing activity. | Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
Yu C, Gong Y, Zhou H, Wang M, Kong L, Liu J, An T, Zhu H, Li Y., Free PMC Article | 10/28/2017 |
| Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. | Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases.
Li W, Li W, Laishram RS, Hoque M, Ji Z, Tian B, Anderson RA., Free PMC Article | 10/14/2017 |
| Star-PAP recognises a unique nucleotide motif on its target mRNA.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. | CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.
Kandala DT, Mohan N, A V, A P S, G R, Laishram RS., Free PMC Article | 06/28/2016 |
| Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. | Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a.
Zhu DQ, Lou YF, He ZG, Ji M. | 03/21/2015 |
| Star-PAP controls E6 mRNA polyadenylation and expression and modulates wild-type p53 levels. | Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16.
Li W, Anderson RA., Free PMC Article | 04/19/2014 |
| The human TUT1 nucleotidyl transferase is a global regulator of microRNA abundance. | The human TUT1 nucleotidyl transferase as a global regulator of microRNA abundance.
Knouf EC, Wyman SK, Tewari M., Free PMC Article | 02/15/2014 |
| Star-PAP and its regulatory molecules form a signaling nexus at the 3'-end of target mRNAs to control the expression of select group of genes including the ones involved in stress responses. (Review) | The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs.
Li W, Laishram RS, Anderson RA., Free PMC Article | 08/10/2013 |
| PIPKIalpha, PI4,5P(2), and PKCdelta regulate Star-PAP control of BIK expression and induction of apoptosis. | Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling.
Li W, Laishram RS, Ji Z, Barlow CA, Tian B, Anderson RA., Free PMC Article | 03/31/2012 |
| The data support a model where Star-PAP binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. | The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA.
Laishram RS, Anderson RA., Free PMC Article | 01/15/2011 |
| These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages. | CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.
Gonzales ML, Mellman DL, Anderson RA., Free PMC Article | 01/21/2010 |
| PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, Star-PAP; the activity of Star-PAP can be specifically regulated by PtdIns4,5P2 | A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.
Mellman DL, Gonzales ML, Song C, Barlow CA, Wang P, Kendziorski C, Anderson RA. | 01/21/2010 |