| SLC13A3 is a major effector downstream of activated beta-catenin in liver cancer pathogenesis. | SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis.
Zhao W, Wang X, Han L, Zhang C, Wang C, Kong D, Zhang M, Xu T, Li G, Hu G, Luo J, Yee SW, Yang J, Stahl A, Chen X, Zhang Y., Free PMC Article | 09/4/2024 |
| Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability. | Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability.
Hussain SI, Muhammad N, Shah SUD, Fardous F, Khan SA, Khan N, Rehman AU, Siddique M, Wasan SA, Niaz R, Ullah H, Khan N, Muhammad N, Mirza MU, Wasif N, Khan S., Free PMC Article | 11/1/2023 |
| Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients. | Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients.
Kumari R, Tiwari S, Atlani M, Anirudhan A, Goel SK, Kumar A. | 07/27/2023 |
| NaDC3-related immunostaining was detected in the basolateral membrane of proximal tubules and in the basolateral membrane and/or luminal membrane of principal cells in connecting segments and collecting ducts | Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.
Breljak D, Ljubojević M, Hagos Y, Micek V, Balen Eror D, Vrhovac Madunić I, Brzica H, Karaica D, Radović N, Kraus O, Anzai N, Koepsell H, Burckhardt G, Burckhardt BC, Sabolić I. | 07/22/2017 |
| OAT1 and NaDC3 in the basolateral membrane and OAT4 in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate. | Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.
Schwob E, Hagos Y, Burckhardt G, Burckhardt BC. | 02/14/2015 |
| In a study addressing genetic, social, and environmental contributors of chronic kidney disease with tubulointerstitial damages in Sri Lanka, SNP rs6066043 of SLC13A3 was found attributable risk of 50%. | An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.
Nanayakkara S, Senevirathna ST, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne ED, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A. | 12/27/2014 |
| study concludes NaDC3 present at the basolateral membrane of proximal tubule cells mediates sodium-dependent glutathione (GSH) uptake; the kinetic data show that NaDC3 is a low-affinity GSH transporter | Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter.
Schorbach L, Krick W, Burckhardt G, Burckhardt BC. | 07/5/2014 |
| The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 | Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.
Kaufhold M, Schulz K, Breljak D, Gupta S, Henjakovic M, Krick W, Hagos Y, Sabolic I, Burckhardt BC, Burckhardt G. | 12/17/2011 |
| The results indicate that SLC13A3 is a direct downstream target of PITX2 transcriptional regulation and that levels of PITX2 and SLC13A3 modulate responses to oxidative stress in ocular cells. | PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.
Strungaru MH, Footz T, Liu Y, Berry FB, Belleau P, Semina EV, Raymond V, Walter MA., Free PMC Article | 12/17/2011 |
| NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1. | High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1.
Liu W, Hong Q, Bai XY, Fu B, Xie Y, Zhang X, Li J, Shi S, Lv Y, Sun X, Chen X., Free PMC Article | 01/29/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.
Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Rich SS, Bowden DW, Mychaleckyj JC., Free PMC Article | 07/16/2008 |
| The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3. | Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.
Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G. | 01/21/2010 |
| We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3. | Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3.
Bai X, Chen X, Feng Z, Hou K, Zhang P, Fu B, Shi S. | 01/21/2010 |