| USP5 enhances SGTA mediated protein quality control. | USP5 enhances SGTA mediated protein quality control.
Hill J, Nyathi Y., Free PMC Article | 08/6/2022 |
| SGTA associates with intracellular aggregates in neurodegenerative diseases. | SGTA associates with intracellular aggregates in neurodegenerative diseases.
Kubota S, Doi H, Koyano S, Tanaka K, Komiya H, Katsumoto A, Ikeda S, Hashiguchi S, Nakamura H, Fukai R, Takahashi K, Kunii M, Tada M, Takeuchi H, Tanaka F., Free PMC Article | 12/11/2021 |
| SGTA associates with nascent membrane protein precursors. | SGTA associates with nascent membrane protein precursors.
Leznicki P, High S., Free PMC Article | 05/8/2021 |
| The SGTA is a co-chaperone that, in collaboration with the complex of BAG6, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment. | The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.
Benarroch R, Austin JM, Ahmed F, Isaacson RL., Free PMC Article | 11/23/2019 |
| the results provide novel insights into the structural complexity of SGTA and provide a new basis for mechanistic studies of substrate binding and release at the C-terminal region. | Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL., Free PMC Article | 05/18/2019 |
| evidence that the interaction can mediate the association of Rpn13 and SGTA in a cellular context. | SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.
Thapaliya A, Nyathi Y, Martínez-Lumbreras S, Krysztofinska EM, Evans NJ, Terry IL, High S, Isaacson RL., Free PMC Article | 05/12/2018 |
| Coimmunoprecipitation studies indicated that non-glycosylated tetherin is stabilized through the formation of a ternary SGTA/Vpu/tetherin complex. Although the results do not provide support for a physiological function of SGTA in HIV-1 replication, they demonstrate that SGTA overexpression regulates tetherin expression and stability, thus providing insights into the function of SGTA in endoplasmic reticulum translocation | The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.
Waheed AA, MacDonald S, Khan M, Mounts M, Swiderski M, Xu Y, Ye Y, Freed EO., Free PMC Article | 01/20/2018 |
| study demonstrates a critical role of Hsc70 in SV40 endoplasmic reticulum-to-cytosol penetration and reveal how SGTA controls Hsc70 to impact this process | SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.
Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B., Free PMC Article | 07/29/2017 |
| the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation. | Binding of SGTA to Rpn13 selectively modulates protein quality control.
Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S., Free PMC Article | 06/4/2016 |
| data suggest that SGTA regulates the cellular fate of a range of hydrophobic polypeptides should they become exposed to the cytosol. | SGTA regulates the cytosolic quality control of hydrophobic substrates.
Wunderley L, Leznicki P, Payapilly A, High S., Free PMC Article | 09/5/2015 |
| Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT). | Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.
Darby JF, Krysztofinska EM, Simpson PJ, Simon AC, Leznicki P, Sriskandarajah N, Bishop DS, Hale LR, Alfano C, Conte MR, Martínez-Lumbreras S, Thapaliya A, High S, Isaacson RL., Free PMC Article | 07/25/2015 |
| SGTA overexpression may be involved in the pathogenesis of breast cancer which might serve as a future target for novel treatment in breast cancer. | Expression and prognostic role of SGTA in human breast carcinoma correlates with tumor cell proliferation.
Zhu T, Ji Z, Xu C, Peng Z, Gu L, Zhang R, Liu Y. | 07/25/2015 |
| Our data suggest a role for SGTA at distinct steps in the chaperone-dependent modulation of androgen, glucocorticoid, and progesterone receptor activity. | The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.
Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB., Free PMC Article | 10/11/2014 |
| SGTA depletion decreased cyclin A and cyclin B levels. | Expression of SGTA correlates with prognosis and tumor cell proliferation in human hepatocellular carcinoma.
Lu C, Liu G, Cui X, Zhang J, Wei L, Wang Y, Yang X, Liu Y, Cong X, Lv L, Ni R, Huang X. | 10/4/2014 |
| A role of SGTA in Non-Hodgkin's lymphoma (NHL) cell proliferation, adhesion and drug resistance, and it may pave the way for a novel therapeutic approach for cell adhesion-mediated drug resistance in NHL. | Expression of small glutamine-rich TPR-containing protein A (SGTA) in Non-Hodgkin's Lymphomas promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR).
Wang Y, Huang Y, Xu X, Tang J, Huang X, Zhu J, Liu J, Miao X, Wu Y, Yang F, Ji L, He S. | 09/27/2014 |
| High expression of SGTA in esophageal squamous cell carcinoma correlates with proliferation and poor prognosis. | High expression of SGTA in esophageal squamous cell carcinoma correlates with proliferation and poor prognosis.
Yang X, Cheng L, Li M, Shi H, Ren H, Ding Z, Liu F, Wang Y, Cheng C. | 09/6/2014 |
| Univariate analysis showed that the low SGTB expression was associated with poor prognosis (P<0.001) | Decreased expression of Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) correlated with prognosis of Hepatocellular carcinoma.
Zhang J, Lu C, He S, Wan C, Zhang Y, Cheng C. | 03/22/2014 |
| showed a significant increase in the AR:SGTA ratio in cancerous lesions compared to patient-matched benign prostatic hyperplasia tissue | Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation.
Trotta AP, Need EF, Selth LA, Chopra S, Pinnock CB, Leach DA, Coetzee GA, Butler LM, Tilley WD, Buchanan G. | 12/14/2013 |
| High Small glutamine-rich tetratricopeptide repeat-containing protein alpha expression is associated with non-small-cell lung cancer tumorigenesis. | Expression and clinical role of small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) as a novel cell cycle protein in NSCLC.
Xue Q, Lv L, Wan C, Chen B, Li M, Ni T, Liu Y, Liu Y, Cong X, Zhou Y, Ni R, Mao G. | 11/2/2013 |
| SGTA is present in human ovaries and has the potential to modulate androgen receptor signalling, but it may not be differentially expressed in polycystic ovary syndrome. | Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome.
Butler MS, Yang X, Ricciardelli C, Liang X, Norman RJ, Tilley WD, Hickey TE. | 07/27/2013 |
| SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. | SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
Xu Y, Cai M, Yang Y, Huang L, Ye Y., Free PMC Article | 06/8/2013 |
| Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. | Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Chartron JW, VanderVelde DG, Clemons WM Jr., Free PMC Article | 06/8/2013 |
| Homodimerizaion of SGTA is dependent on the structural integrity of amino acids 1-80, and a core evolutionary conserved peptide within this region (amino acids 21-40) necessary for an effect of SGTA on the activity of the androgen receptor. | Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client.
Trotta AP, Need EF, Butler LM, Selth LA, O'Loughlin MA, Coetzee GA, Tilley WD, Buchanan G. | 02/16/2013 |
| A BAG6/SGTA cycle operates during protein maturation and quality control in the cytosol. | SGTA antagonizes BAG6-mediated protein triage.
Leznicki P, High S., Free PMC Article | 02/2/2013 |
| findings show that the HERV-K(HML-2) Rec protein binds to hSGT and interferes with its role as a negative regulator of the androgen receptor (AR), resulting in enhanced AR activity | The Rec protein of HERV-K(HML-2) upregulates androgen receptor activity by binding to the human small glutamine-rich tetratricopeptide repeat protein (hSGT).
Hanke K, Chudak C, Kurth R, Bannert N. | 02/2/2013 |