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    SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6446, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Cholesterol promotes IFNG mRNA expression in CD4[+] effector/memory cells by SGK1 activation.

    Cholesterol promotes IFNG mRNA expression in CD4(+) effector/memory cells by SGK1 activation.
    Hanin A, Comi M, Sumida TS, Hafler DA., Free PMC Article

    10/16/2024
    MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury.

    MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury.
    Chen D, Li K, Pan L, Chen M, Zhang X, Chen H, Xu J, Cai F.

    08/22/2024
    Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1.

    Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1.
    Lu C, Zheng F, Pan L, Han Q, Wu J, Zhang W.

    08/7/2024
    Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.

    Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
    Zhuang L, Jin G, Wang Q, Ge X, Pei X.

    07/15/2024
    Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression.

    Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression.
    Oda S, Yokoyama A, Kishii R, Nagasawa M.

    06/25/2024
    SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.

    SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
    Wu J, Gong L, Li Y, Liu T, Sun R, Jia K, Liu R, Dong F, Gu X, Li X., Free PMC Article

    02/16/2024
    Proteomics on malignant pleural effusions reveals ERalpha loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.

    Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.
    Mayayo-Peralta I, Debets DO, Prekovic S, Schuurman K, Beerthuijzen S, Almekinders M, Sanders J, Moelans CB, Saleiro S, Wesseling J, van Diest PJ, Henrique R, Jerónimo C, Altelaar M, Zwart W., Free PMC Article

    01/6/2024
    Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.

    Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.
    Zhuang L, Jin G, Qiong W, Ge X, Pei X., Free PMC Article

    01/4/2024
    Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.

    Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
    Di X, Hao Y, Duan Z, Ma Y, Cao Y, Tan Z, Song C, Lin X., Free PMC Article

    11/15/2023
    Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.

    Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
    Chen B, Song Y, Yang X, Yang J, Hao F.

    10/26/2023
    Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.

    Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.
    Bian X, Xue H, Jing D, Wang Y, Zhou G, Zhu F.

    10/24/2023
    Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation.

    Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation.
    Gu W, Zheng H, Canessa CM., Free PMC Article

    09/13/2023
    Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients.

    Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients.
    Zhang J, Miki Y, Iwabuchi E, Xu J, Kanai A, Sagara Y, Ohi Y, Rai Y, Yamaguchi R, Tanaka M, Ishida T, Suzuki T, Sasano H.

    06/29/2023
    [SGK1 as a therapeutic target for central nervous system diseases].

    [SGK1 as a therapeutic target for central nervous system diseases].
    Xing YK, Luo W, Fan MY, Tan YW, Li X.

    06/23/2023
    ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.

    ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
    Li Y, Liu C, Rolling L, Sikora V, Chen Z, Gurwin J, Barabell C, Lin J, Duan C., Free PMC Article

    06/13/2023
    Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2.

    Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2.
    Giannetti F, Barbieri M, Shiti A, Casini S, Sager PT, Das S, Pradhananga S, Srinivasan D, Nimani S, Alerni N, Louradour J, Mura M, Gnecchi M, Brink P, Zehender M, Koren G, Zaza A, Crotti L, Wilde AAM, Schwartz PJ, Remme CA, Gepstein L, Sala L, Odening KE., Free PMC Article

    06/1/2023
    SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.

    SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.
    Hara Y, Lemgart VT, Halland N, Mahdaviani K, Ribeil JA, Lessard S, Hicks A, Light DR., Free PMC Article

    05/30/2023
    The Serum/Glucocorticoid-Regulated Kinase 1 Is Targeted by miR-19a in CD4+ T Cells.

    The Serum/Glucocorticoid-Regulated Kinase 1 Is Targeted by miR-19a in CD4+ T Cells.
    Weidner J, Malmhäll C, Arabkari V, Barrett A, Boberg E, Ekerljung L, Rådinger M., Free PMC Article

    01/21/2023
    Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation.

    Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation.
    Bapat A, Li G, Xiao L, Yeri A, Hulsmans M, Grune J, Yamazoe M, Schloss MJ, Iwamoto Y, Tedeschi J, Yang X, Nahrendorf M, Rosenzweig A, Ellinor PT, Das S, Milan D., Free PMC Article

    01/14/2023
    Expression and clinicopathological significance of glucocorticoid receptor, SGK1, and NDRG1 in hormone-naive prostate carcinoma.

    Expression and clinicopathological significance of glucocorticoid receptor, SGK1, and NDRG1 in hormone-naïve prostate carcinoma.
    Hata S, Shimada H, Sato N, Koshiishi M, Ise K, Ogata T, Yamashita S, Ito A, Sasano H, Nakamura Y.

    11/5/2022
    Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.

    Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.
    Wu Y, Wang H, Li Y, Li Y, Liang Y, Zhong G, Zhang Q.

    10/15/2022
    Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling.

    Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling.
    Araki T, Watanabe Y, Okada Y, Murakami H, Ogo N, Asai A.

    05/14/2022
    SGK1 mutation status can further stratify patients with germinal center B-cell-like diffuse large B-cell lymphoma into different prognostic subgroups.

    SGK1 mutation status can further stratify patients with germinal center B-cell-like diffuse large B-cell lymphoma into different prognostic subgroups.
    Guo B, Huang Y, Duan Y, Liao C, Cen H., Free PMC Article

    04/30/2022
    SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease.

    SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease.
    Lu RQ, Zhang YY, Zhao HQ, Guo RQ, Jiang ZX, Guo R., Free PMC Article

    04/16/2022
    SGK1, autophagy and cancer: an overview.

    SGK1, autophagy and cancer: an overview.
    Ghani MJ.

    03/26/2022
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