| Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells. | Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells.
Zarychta J, Kowalczyk A, Słowik K, Przywara D, Petniak A, Kondracka A, Wójtowicz-Marzec M, Słyk-Gulewska P, Kwaśniewska A, Kocki J, Gil-Kulik P., Free PMC Article | 11/5/2024 |
| Hypoxia Inducible Factors (HIF1alpha and HIF3alpha) are differentially methylated in preeclampsia placentae and are associated with birth outcomes. | Hypoxia Inducible Factors (HIF1α and HIF3α) are differentially methylated in preeclampsia placentae and are associated with birth outcomes.
Kaur L, Sundrani D, Dave K, Randhir K, Mehendale S, Bayyana S, Kalyanaraman K, Chandak GR, Joshi S. | 09/27/2023 |
| DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A. | DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A.
Dai Y, Xuan G, Yin M., Free PMC Article | 09/19/2023 |
| HIF-3alpha-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop. | HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop.
Gao Q, Ren Z, Jiao S, Guo J, Miao X, Wang J, Liu J., Free PMC Article | 10/29/2022 |
| Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study. | Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study.
Mizuno G, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Fujii R, Tsuboi Y, Teshigawara A, Kageyama I, Osakabe K, Sugimoto K, Ishikawa H, Ichino N, Ohta Y, Ohashi K, Hashimoto S, Suzuki K. | 10/22/2022 |
| Short-chain fatty acids combined with intronic DNA methylation of HIF3A: Potential predictors for diabetic cardiomyopathy. | Short-chain fatty acids combined with intronic DNA methylation of HIF3A: Potential predictors for diabetic cardiomyopathy.
Guo Y, Zou J, Xu X, Zhou H, Sun X, Wu L, Zhang S, Zhong X, Xiong Z, Lin Y, Huang Y, Du Z, Liao X, Zhuang X. | 01/29/2022 |
| Hypoxia inducible factor-3alpha promotes osteosarcoma progression by activating KDM3A-mediated demethylation of SOX9. | Hypoxia inducible factor-3α promotes osteosarcoma progression by activating KDM3A-mediated demethylation of SOX9.
Li ZF, Meng DD, Liu YY, Bi FG, Tian K, Xu JZ, Sun JG, Gu CX, Li Y. | 01/15/2022 |
| Aberrant expression of HIF3A in plasma of patients with non-small cell lung cancer and its clinical significance. | Aberrant expression of HIF3A in plasma of patients with non-small cell lung cancer and its clinical significance.
Wei L, Yuan N, Chen Y, Gong P., Free PMC Article | 01/15/2022 |
| A Functional Polymorphism in HIF-3alpha Is Related to an Increased Risk of Ischemic Stroke. | A Functional Polymorphism in HIF-3α Is Related to an Increased Risk of Ischemic Stroke.
Gu XX, Tang ZZ, He YL, Zeng ZN, Shi WX, Qiao YC, Wei YS., Free PMC Article | 11/22/2021 |
| HIF3A DNA methylation, obesity and weight gain, and breast cancer risk among Mexican American women. | HIF3A DNA methylation, obesity and weight gain, and breast cancer risk among Mexican American women.
Shen J, Song R, Ye Y, Wu X, Chow WH, Zhao H. | 09/4/2021 |
| HIF3A cord blood methylation and systolic blood pressure at 4 years - a population-based cohort study. | HIF3A cord blood methylation and systolic blood pressure at 4 years - a population-based cohort study.
Mansell T, Burgner D, Ponsonby AL, Collier F, Pezic A, Vuillermin P, Juonala M, Ryan J, Saffery R., Free PMC Article | 06/26/2021 |
| Knockdown of MALAT1 Inhibits the Progression of Chronic Periodontitis via Targeting miR-769-5p/HIF3A Axis. | Knockdown of MALAT1 Inhibits the Progression of Chronic Periodontitis via Targeting miR-769-5p/HIF3A Axis.
Chen Q, Cao M, Ge H., Free PMC Article | 05/29/2021 |
| HIF3alpha affects preeclampsia development by regulating EVT growth via activation of the Flt1/JAK/STAT signaling pathway in hypoxia. | HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia.
Qu H, Yu Q, Jia B, Zhou W, Zhang Y, Mu L., Free PMC Article | 04/17/2021 |
| The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism. | The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism.
Sun DG, Tian S, Zhang L, Hu Y, Guan CY, Ma X, Xia HF., Free PMC Article | 03/27/2021 |
| LINC01342 promotes the progression of ovarian cancer by absorbing microRNA-30c-2-3p to upregulate HIF3A. | LINC01342 promotes the progression of ovarian cancer by absorbing microRNA-30c-2-3p to upregulate HIF3A.
Zhang C, Liu J, Zhang Y, Luo C, Zhu T, Zhang R, Yao R. | 02/6/2021 |
| Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients. | Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients.
Lee MC, Hsiao TH, Chuang HN, Lee LW, Chi PL, Tsai HM, Mao CL, Hsu CP. | 02/6/2021 |
| Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3alpha. | Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α.
Wang Y, Gong W, Lv S, Qu H, He Y., Free PMC Article | 09/19/2020 |
| expression reduced in psoriatic epidermis | Psoriasis-like skin inflammation is reduced in transgenic mice overexpressing inhibitory PAS domain protein.
Shibuya T, Iinuma S, Honma M, Makino Y, Ishida-Yamamoto A. | 06/6/2020 |
| Pre- and perinatal factors impact HIF3A methylation, including pre-eclampsia. This provides evidence that specific pregnancy complications, previously linked to adverse outcomes for both mother and child, impact the infant epigenome in a molecular pathway critical to several vascular and metabolic conditions. | Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study.
Mansell T, Ponsonby AL, Januar V, Novakovic B, Collier F, Burgner D, Vuillermin P, Ryan J, Saffery R, Barwon Infant Study Investigator Team., Free PMC Article | 05/30/2020 |
| HIF-3alpha showed reduced expression in myofibroblasts from idiopathic pulmonary fibrosis patients. | Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis.
Aquino-Gálvez A, González-Ávila G, Jiménez-Sánchez LL, Maldonado-Martínez HA, Cisneros J, Toscano-Marquez F, Castillejos-López M, Torres-Espíndola LM, Velázquez-Cruz R, Rodríguez VHO, Flores-Soto E, Solís-Chagoyán H, Cabello C, Zúñiga J, Romero Y., Free PMC Article | 01/11/2020 |
| HIF-3alpha translocated to mitochondrial outer membrane under both normoxia and hypoxia, and hypoxia could up-regulate HIF-3alpha mitochondrial translocation | [Expression and Significance of HIF-3α in Mitochondria].
Li L, Zhou YN, Li SF, Long D, Li HS, Feng L, Li YP. | 12/7/2019 |
| Study in human mesenchymal stromal/stem cells revealed robust hypermethylation of histone H3 across HIF3A locus driven by pro-inflammatory cytokines. Experiments in a murine model of arteriotomy highlighted the activation of Hif3alpha expression in infiltrated inflammatory cells, suggesting a new role for Hif3alpha in inflammation in vivo. | Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells.
Cuomo F, Coppola A, Botti C, Maione C, Forte A, Scisciola L, Liguori G, Caiafa I, Ursini MV, Galderisi U, Cipollaro M, Altucci L, Cobellis G., Free PMC Article | 10/26/2019 |
| Study mapped the functional nuclear localization signal (NLS) to the unique C-terminal region of Hif-3alpha and identified two clusters of basic residues critical for its nuclear localization. The two NLS motifs are functionally redundant. These results suggest that Hif-3alpha nuclear localization is mediated through two redundant NLS motifs located in its unique C-terminal region. | Nuclear localization of Hif-3α requires two redundant NLS motifs in its unique C-terminal region.
Yao Q, Zhang P, Lu L, Liu Y, Li Y, Duan C. | 06/8/2019 |
| Expression level of HIF3A is downregulated in gestational diabetes patients. The methylation status of HIF3A promoter region is highly correlated with gestational diabetes. | Methylation of HIF3A promoter CpG islands contributes to insulin resistance in gestational diabetes mellitus.
Zhang Y, Chen Y, Qu H, Wang Y., Free PMC Article | 05/25/2019 |
| MicroRNA-300 is a tumor suppressor microRNA in non-small cell lung cancer by downregulating HIF3alpha expression. | MicroRNA-300 targets hypoxia inducible factor-3 alpha to inhibit tumorigenesis of human non-small cell lung cancer.
Zhang Y, Guo Y, Yang C, Zhang S, Zhu X, Cao L, Nie W, Yu H. | 04/27/2019 |