| MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity by suppressing SAT1. | MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity by suppressing SAT1.
Zhao G, Liang J, Zhang Y, Shan G, Bian Y, Gu J, Zhan C, Ge D., Free PMC Article | 10/7/2024 |
| MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression. | MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression.
Deng L, Liao L, Zhang YL, Hu SY, Yang SY, Ma XY, Huang MY, Zhang FL, Li DQ. | 04/12/2023 |
| Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus. | Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.
Xu L, Zhao J, Sun Q, Xu X, Wang L, Liu T, Wu Y, Zhu J, Geng L, Deng Y, Awgulewitsch A, Kamen DL, Oates JC, Raj P, Wakeland EK, Scofield RH, Guthridge JM, James JA, Hahn BH, McCurdy DK, Wang F, Zhang M, Tan W, Gilkeson GS, Tsao BP., Free PMC Article | 11/19/2022 |
| ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis. | ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis.
Sui X, Hu N, Zhang Z, Wang Y, Wang P, Xiu G. | 02/12/2022 |
| Dengue virus targets RBM10 deregulating host cell splicing and innate immune response. | Dengue virus targets RBM10 deregulating host cell splicing and innate immune response.
Pozzi B, Bragado L, Mammi P, Torti MF, Gaioli N, Gebhard LG, García Solá ME, Vaz-Drago R, Iglesias NG, García CC, Gamarnik AV, Srebrow A., Free PMC Article | 09/12/2020 |
| Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma. | Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma.
Cai C, Xie X, Zhou J, Fang X, Wang F, Wang M. | 08/29/2020 |
| CRISPR knockin mutants demonstrate the essentiality of the polyamine acetyltransferase activity of SAT1 for its function as a transcriptional regulator | Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.
Thakur VS, Aguila B, Brett-Morris A, Creighton CJ, Welford SM., Free PMC Article | 02/29/2020 |
| SSATX, an alternative splicing variant of the SAT1 gene, is proposed to function as a long non-coding RNA prior to its degradation in melanoma cells. | Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.
Yang Q, Deng Y, Xu Y, Ding N, Wang C, Zhao X, Lou X, Li Y, Zhao H, Fang X. | 09/7/2019 |
| Activation of SAT1 expression induces lipid peroxidation and sensitizes cells to undergo ferroptosis upon reactive oxygen species (ROS)-induced stress, which also leads to suppression of tumor growth in xenograft tumor models. Notably, SAT1 expression is down-regulated in human tumors, and CRISPR-cas9-mediated knockout of SAT1 expression partially abrogates p53-mediated ferroptosis. Moreover, SAT1 induction is correlated | Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.
Ou Y, Wang SJ, Li D, Chu B, Gu W., Free PMC Article | 03/24/2018 |
| our results indicated depletion of polyamines by SSAT signi fi cantly inhibited cell proliferation, migration and invasion through AKT/GSK3beta/beta-catenin signaling pathway in hepatocellular carcinoma and colorectal cancer cells. | Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Wang C, Ruan P, Zhao Y, Li X, Wang J, Wu X, Liu T, Wang S, Hou J, Li W, Li Q, Li J, Dai F, Fang D, Wang C, Xie S., Free PMC Article | 03/10/2018 |
| Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT expression, and the Akt1-mediated pathway. | Extracellular polyamines-induced proliferation and migration of cancer cells by ODC, SSAT, and Akt1-mediated pathway.
Dai F, Yu W, Song J, Li Q, Wang C, Xie S. | 11/18/2017 |
| we used siRNA on SSAT and compared the SSAT level in knockdown and normal cells. Results showed that the monoclonal antibody specifically recognized SSAT. | Monoclonal Antibody Against Spermidine/Spermine N1-Acetyltransferase.
| 04/22/2017 |
| 4H6 was also compared with the commercial antibody. The produced mAbs will be a useful tool for further investigation of SSAT functions in organisms. | Preparation of Antispermidine/Spermine-N1-Acetyltransferase Monoclonal Antibodies.
Chen Y, Zhang C. | 04/22/2017 |
| Results show low SAT1 brain expression in depressed suicides and implicate low SAT1 brain expression in major depression independent of suicide | Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide.
Pantazatos SP, Andrews SJ, Dunning-Broadbent J, Pang J, Huang YY, Arango V, Nagy PL, John Mann J., Free PMC Article | 03/5/2016 |
| Data suggest that SAT1 plays role in apoptosis; overexpression of SAT1 in human embryonic kidney cell line leads to a rapid depletion of spermidine and spermine, arrest in cell growth, and mitochondria-mediated apoptosis. | Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells.
Mandal S, Mandal A, Park MH., Free PMC Article | 10/10/2015 |
| Analysis shows a significant direct correlation between SSAT expression in Prostatic Cancer tissues and disease progression. | Expression of spermidine/spermine N(1) -acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis.
Huang W, Eickhoff JC, Mehraein-Ghomi F, Church DR, Wilding G, Basu HS., Free PMC Article | 08/29/2015 |
| Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response | Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.
Zahedi K, Barone S, Wang Y, Murray-Stewart T, Roy-Chaudhury P, Smith RD, Casero RA Jr, Soleimani M., Free PMC Article | 07/25/2015 |
| A role for SAT1 in homologous recombination. | The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM.
Brett-Morris A, Wright BM, Seo Y, Pasupuleti V, Zhang J, Lu J, Spina R, Bar EE, Gujrati M, Schur R, Lu ZR, Welford SM., Free PMC Article | 03/7/2015 |
| The Catabolic enzyme SSAT expression levels was up-regulated in both cell lines; however, the specific SSAT siRNA treatments prevented the EBR-induced apoptosis only in LNCaP (AR+) cells. | Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines.
Obakan P, Arisan ED, Calcabrini A, Agostinelli E, Bolkent S, Palavan-Unsal N. | 02/14/2015 |
| In females, the TC genotype was significantly more frequent in alcohol-dependent patients than in non-alcohol-dependent psychiatric controls. No differences were found among the males. | Putative association between the -1415 T/C polymorphism of spermidine/spermine N1-acetyltransferase (SSAT1) gene and alcohol use disorders in women and men.
Vaquero-Lorenzo C, López-Castromán J, Bermudo-Soriano CR, Saiz-Ruiz J, Fernández-Piqueras J, Baca-García E. | 12/20/2014 |
| study postulates a mechanism for SAT1 and SMOX down-regulation by post-transcriptional activity of miRNAs. | Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.
Lopez JP, Fiori LM, Gross JA, Labonte B, Yerko V, Mechawar N, Turecki G. | 11/29/2014 |
| SAT1 transcription is influenced by lithium and this effect is altered in bipolar disease patients who completed suicide. | Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour.
Squassina A, Manchia M, Chillotti C, Deiana V, Congiu D, Paribello F, Roncada P, Soggiu A, Piras C, Urbani A, Robertson GS, Keddy P, Turecki G, Rouleau GA, Alda M, Del Zompo M. | 07/5/2014 |
| berberine inhibits cellular growth by affecting polyamine metabolism, in particular through the upregulation of the key catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). | Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.
Marverti G, Ligabue A, Lombardi P, Ferrari S, Monti MG, Frassineti C, Costi MP. | 04/12/2014 |
| EBV-positive Akata cells demonstrated decreased SAT1 enzyme activity concomitant with altered intracellular polyamine level. | Downregulation of the polyamine regulator spermidine/spermine N(1)-acetyltransferase by Epstein-Barr virus in a Burkitt's lymphoma cell line.
Shi M, Gan YJ, Davis TO, Scott RS., Free PMC Article | 03/22/2014 |
| SSAT translational control mechanisms | Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.
Perez-Leal O, Barrero CA, Clarkson AB, Casero RA Jr, Merali S., Free PMC Article | 06/30/2012 |