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    RPL22 ribosomal protein L22 [ Homo sapiens (human) ]

    Gene ID: 6146, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver.

    CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver.
    Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Ji Z, Wang S, Belmonte JCI, Qu J, Zhang W, Wei T, Liu GH., Free PMC Article

    11/13/2024
    L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.

    L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
    Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X., Free PMC Article

    04/9/2022
    RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.

    RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
    Zeng J, Zhang Y, Zhang H, Zhang Y, Gao L, Tong X, Xie Y, Hu Q, Chen C, Ding S, Lu J., Free PMC Article

    12/18/2021
    Post-transcriptional regulation of C-C motif chemokine ligand 2 expression by ribosomal protein L22 during LPS-mediated inflammation.

    Post-transcriptional regulation of C-C motif chemokine ligand 2 expression by ribosomal protein L22 during LPS-mediated inflammation.
    Das AS, Basu A, Kumar R, Borah PK, Bakshi S, Sharma M, Duary RK, Ray PS, Mukhopadhyay R.

    05/15/2021
    Intratumoral Heterogeneity of RPL22 Frameshift Mutation in Colorectal Cancers.

    Intratumoral Heterogeneity of RPL22 Frameshift Mutation in Colorectal Cancers.
    Lee JH, An CH, Kim MS, Yoo NJ, Lee SH.

    10/24/2020
    RPL22/eL22 can interact with and inhibit CDK4-Cyclin D1 to decrease RB phosphorylation.

    Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
    Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F., Free PMC Article

    04/18/2020
    considering the high mutation frequency found, our data point toward an important role for RPL22 in microsatellite instability carcinogenesis

    High frequency of RPL22 mutations in microsatellite-unstable colorectal and endometrial tumors.
    Ferreira AM, Tuominen I, van Dijk-Bos K, Sanjabi B, van der Sluis T, van der Zee AG, Hollema H, Zazula M, Sijmons RH, Aaltonen LA, Westers H, Hofstra RM.

    07/25/2015
    Study revealved that RPL22 binds CK2alpha in lung cancer cells.

    Interaction of ribosomal protein L22 with casein kinase 2α: a novel mechanism for understanding the biology of non-small cell lung cancer.
    Yang M, Sun H, He J, Wang H, Yu X, Ma L, Zhu C.

    01/17/2015
    Down-regulation of RPL22 might be involved in the carcinogenesis of NSCLC.

    Down-regulation of ribosomal protein L22 in non-small cell lung cancer.
    Yang M, Sun H, Wang H, Zhang S, Yu X, Zhang L.

    04/19/2014
    RPL22 is frequently mutated in MSI-high endometrioid endometrial cancers. The A8 mutation identified was not reported in the whole exome sequences analyzed by the TCGA.

    Frequent mutations in the RPL22 gene and its clinical and functional implications.
    Novetsky AP, Zighelboim I, Thompson DM Jr, Powell MA, Mutch DG, Goodfellow PJ., Free PMC Article

    06/29/2013
    Rpl22 inactivation promotes neoplastic transformation by inducing expression of Lin28B

    Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
    Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL., Free PMC Article

    01/5/2013
    Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 binding

    Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 binding.
    Houmani JL, Davis CI, Ruf IK., Free PMC Article

    01/21/2010
    The EBER in situ hybridization showed negative results despite racial or geographical factors might influence the peculiar susceptibility of individuals of Asian ancestry to Epstein-Barr virus-associated lymphoepithelioma-like carcinoma.

    EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients.
    Chen KC, Chiang HS, Fang CL.

    01/21/2010
    Multiple domains of EBER 1 recruit ribosomal protein L22.

    Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22.
    Fok V, Mitton-Fry RM, Grech A, Steitz JA., Free PMC Article

    01/21/2010
    The EBER-ISH as an independent prognostic factor of NPC regardless of histopathology.

    Analysis of prognostic factors of nasopharyngeal carcinoma: impact of in situ hybridization for Epstein-Barr virus encoded small RNA 1.
    Nakao K, Mochiki M, Nibu K, Sugasawa M, Uozaki H.

    01/21/2010
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