| Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma. | Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma.
Youssef SS, El-Araby RE, Abbas EAE, Hassany M, Elbaz T. | 03/31/2023 |
| Hypoxia-inducible factor 1alpha induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/beta-catenin transcriptional cofactor BCL9. | Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9.
Orikasa S, Kawashima N, Tazawa K, Hashimoto K, Sunada-Nara K, Noda S, Fujii M, Akiyama T, Okiji T., Free PMC Article | 03/5/2022 |
| The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus promote breast cancer growth, invasion, and metastasis. | The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.
Vafaizadeh V, Buechel D, Rubinstein N, Kalathur RKR, Bazzani L, Saxena M, Valenta T, Hausmann G, Cantù C, Basler K, Christofori G., Free PMC Article | 01/1/2022 |
| Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer. | Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
Chatziandreou I, Psaraki A, Paschidis K, Lazaris AC, Saetta AA. | 11/27/2021 |
| BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. | BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
Wang X, Feng M, Xiao T, Guo B, Liu D, Liu C, Pei J, Liu Q, Xiao Y, Rosin-Arbesfeld R, Shi Y, Zhou Y, Yang M, Feng YX, Jiang Y, Shao Z, Yu K, Zhu D. | 11/6/2021 |
| LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/beta-catenin signaling. | LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling.
Guan B, Ma J, Yang Z, Yu F, Yao J. | 08/21/2021 |
| miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2. | miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2.
Liu D, Chen C, Cui M, Zhang H., Free PMC Article | 07/24/2021 |
| MiR-30c exerts tumor suppressive functions in colorectal carcinoma by directly targeting BCL9. | MiR-30c exerts tumor suppressive functions in colorectal carcinoma by directly targeting BCL9.
Zhao DW, Li MM, Han JP, Wang Y, Jiang LX, Chang HL. | 09/12/2020 |
| In response to spontaneous calcium transients or cellular stress, BCL9 is recruited adjacent to the interchromosomal regions, where it stabilizes the mRNA of calcium signaling and neural associated genes by interacting with paraspeckle proteins. | BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins.
Jiang M, Kang Y, Sewastianik T, Wang J, Tanton H, Alder K, Dennis P, Xin Y, Wang Z, Liu R, Zhang M, Huang Y, Loda M, Srivastava A, Chen R, Liu M, Carrasco RD., Free PMC Article | 04/25/2020 |
| Investigated targeting the protein interactions of catenin beta 1 and B-cell lymphoma 9 protein (BCL9) binding using peptides designed by peptidomimetic drug design. | Inhibition of β-catenin/B cell lymphoma 9 protein-protein interaction using α-helix-mimicking sulfono-γ-AApeptide inhibitors.
Sang P, Zhang M, Shi Y, Li C, Abdulkadir S, Li Q, Ji H, Cai J., Free PMC Article | 04/4/2020 |
| results revealed a novel role of BCL9 in controlling mitotic Wnt signalling to promote cell division and growth. | CDK1-mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling.
Chen J, Rajasekaran M, Xia H, Kong SN, Deivasigamani A, Sekar K, Gao H, Swa HL, Gunaratne J, Ooi LL, Xie T, Hong W, Hui KM., Free PMC Article | 10/5/2019 |
| The gene BCL9 is overexpressed in malignant adrenocortical tumors and promotes clonal ACC cell growth. These findings suggest that BCL9 overexpression may serve as an alternative driver of constitutive Wnt/beta-Catenin activation in ACC and could represent a potential molecular and diagnostic marker of tumor malignancy. | BCL9 Upregulation in Adrenocortical Carcinoma: A Novel Wnt/β-Catenin Activating Event Driving Adrenocortical Malignancy.
Brown TC, Nicolson NG, Korah R, Carling T. | 09/7/2019 |
| SNHG16 promotes BCL9 expression by sponging miR-1301 to facilitate the proliferation, migration and invasion of OS cells. | LncRNA SNHG16 promotes proliferation, migration and invasion of osteosarcoma cells by targeting miR-1301/BCL9 axis.
Wang X, Hu K, Chao Y, Wang L. | 08/31/2019 |
| miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9, and significantly affects the development of H. pylori-induced gastric cancer, shedding new light on the mechanisms underlying H. pylori-associated gastric cancer. | miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models.
Liu X, Ji Q, Zhang C, Liu X, Liu Y, Liu N, Sui H, Zhou L, Wang S, Li Q., Free PMC Article | 02/23/2019 |
| We found that miR-532 was significantly upregulated in patients with intervertebral disc degeneration and plays a pro-apoptotic role in human intervertebral disc nucleus pulposus cells. Further, Bcl-9 was confirmed to be a direct target of miR-532 and might be a potential target for disc degeneration therapy. | MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis.
Sun Z, Jian Y, Fu H, Li B. | 02/16/2019 |
| Specific regulation of BCL9 expression by HIF-1alpha may prove to be an underlying crosstalk between Wnt/beta-catenin signaling and hypoxia signaling pathways. | Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma.
Xu W, Zhou W, Cheng M, Wang J, Liu Z, He S, Luo X, Huang W, Chen T, Yan W, Xiao J., Free PMC Article | 10/20/2018 |
| Results find that BCL9 is upregulated in osteosarcoma (OS) tissues and promotes OS proliferation, migration and invasion. BCL9 is a downstream target of miR-1301 in OS cells. In addition, BCL9 restoration could reversed the functional effects of miR-1301 overexpression on OS cell proliferation, migration and invasion. These results revealed the important role of BCL9 in OS tumor progression. | MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9.
Wang L, Hu K, Chao Y. | 10/20/2018 |
| High BCL9 expression is associated with cisplatin-resistance in non-small cell lung cancer. | BCL9 promotes epithelial mesenchymal transition and invasion in cisplatin resistant NSCLC cells via β-catenin pathway.
Zhang Y, Zhang Q, Chen H, Wang C. | 09/8/2018 |
| results from this study demonstrated that hypoxia induced BCL-9 expression in human CRC cells mainly through HIF-1alpha, which could be an important underlying mechanism for increased BCL-9 expression in CRC. | HIF-1α activates hypoxia-induced BCL-9 expression in human colorectal cancer cells.
Tan Z, Huang Q, Zang J, Teng SF, Chen TR, Wei HF, Song DW, Liu TL, Yang XH, Fu CG, Hu ZQ, Zhou W, Yan WJ, Xiao JR., Free PMC Article | 03/10/2018 |
| SOX7 inhibits oncogenic beta-catenin-mediated transcription by disrupting the beta-catenin/BCL9 interaction. | SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction.
Fan R, He H, Yao W, Zhu Y, Zhou X, Gui M, Lu J, Xi H, Deng Z, Fan M. | 02/24/2018 |
| The authors used CRISPR/Cas9 genome engineering of Drosophila legless (lgs) and human BCL9 and B9L to show that the C-terminus downstream of their adaptor elements is crucial for Wnt responses. | Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.
van Tienen LM, Mieszczanek J, Fiedler M, Rutherford TJ, Bienz M., Free PMC Article | 02/10/2018 |
| MEF2D-BCL9-positive patients had B-cell precursor immunophenotype and were characterized as being older in age, being resistant to chemotherapy, having very early relapse, and having leukemic blasts that mimic morphologically mature B-cell leukemia with markedly high expression of HDAC9. | MEF2D-BCL9 Fusion Gene Is Associated With High-Risk Acute B-Cell Precursor Lymphoblastic Leukemia in Adolescents.
Suzuki K, Okuno Y, Kawashima N, Muramatsu H, Okuno T, Wang X, Kataoka S, Sekiya Y, Hamada M, Murakami N, Kojima D, Narita K, Narita A, Sakaguchi H, Sakaguchi K, Yoshida N, Nishio N, Hama A, Takahashi Y, Kudo K, Kato K, Kojima S. | 07/22/2017 |
| it was demonstrated that miR218 modulated a novel molecular target and the present study provided novel insights into potential mechanisms of RCC oncogenesis. | Differentially expressed microRNA-218 modulates the viability of renal cell carcinoma by regulating BCL9.
Wang J, Ying Y, Bo S, Li G, Yuan F. | 04/8/2017 |
| findings indicate that BCL9 most likely does not harbor a common genetic variant that can increase the risk for schizophrenia in the Japanese population | Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population.
Kimura H, Tanaka S, Kushima I, Koide T, Banno M, Kikuchi T, Nakamura Y, Shiino T, Yoshimi A, Oya-Ito T, Xing J, Wang C, Takasaki Y, Aleksic B, Okada T, Ikeda M, Inada T, Iidaka T, Iwata N, Ozaki N., Free PMC Article | 12/3/2016 |
| BCL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer | BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer.
Moor AE, Anderle P, Cantù C, Rodriguez P, Wiedemann N, Baruthio F, Deka J, André S, Valenta T, Moor MB, Győrffy B, Barras D, Delorenzi M, Basler K, Aguet M., Free PMC Article | 10/22/2016 |