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    RMRP RNA component of mitochondrial RNA processing endoribonuclease [ Homo sapiens (human) ]

    Gene ID: 6023, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    RMRP-related short stature: A report of six additional Japanese individuals with cartilage hair hypoplasia and literature review.

    RMRP-related short stature: A report of six additional Japanese individuals with cartilage hair hypoplasia and literature review.
    Uchida N, Ishii T, Nishimura G, Sato T, Kuratsuji G, Nagasaki K, Hosokawa Y, Adachi E, Takasawa K, Kashimada K, Tsujioka Y, Hasegawa T.

    06/28/2024
    Identification of a founder effect involving n.197C>T variant in RMRP gene associated to cartilage-hair hypoplasia syndrome in Brazilian patients.

    Identification of a founder effect involving n.197C>T variant in RMRP gene associated to cartilage-hair hypoplasia syndrome in Brazilian patients.
    Gomes ME, Kehdy F, de Neves-Manta FS, Horovitz DDG, Sanseverino MT, Leal GF, Felix TM, Cavalcanti DP, Llerena JC Jr, Gonzalez S., Free PMC Article

    06/25/2024
    Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.

    Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.
    Ghamari M, Mehrab Mohseni M, Taheri M, Neishabouri SM, Shirvani-Farsani Z.

    02/7/2024
    m[6]A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.

    m(6)A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.
    Lu X, Chen L, Liu S, Cao Y, Huang Z.

    08/28/2023
    Widespread association of ERalpha with RMRP and tRNA genes in MCF-7 cells and breast cancers.

    Widespread association of ERα with RMRP and tRNA genes in MCF-7 cells and breast cancers.
    Malcolm JR, Leese NK, Lamond-Warner PI, Brackenbury WJ, White RJ., Free PMC Article

    03/19/2022
    A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis.

    A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis.
    Robertson N, Shchepachev V, Wright D, Turowski TW, Spanos C, Helwak A, Zamoyska R, Tollervey D., Free PMC Article

    02/26/2022
    Differential expression analysis of CCDC107 and RMRP lncRNA as potential biomarkers in colorectal cancer diagnosis.

    Differential expression analysis of CCDC107 and RMRP lncRNA as potential biomarkers in colorectal cancer diagnosis.
    Ghanizade P, Oroujalian A, Peymani M.

    02/5/2022
    Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.

    Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.
    Yin C, Bai G, Zhang Y, Huang J.

    01/29/2022
    ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma.

    ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma.
    Yu H, Zhang Z.

    01/8/2022
    lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis.

    lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis.
    Xie Z, Liu S, Chu S, Liu Y, Huang B, Zhang Q., Free PMC Article

    01/1/2022
    Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.

    Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
    Chen Y, Hao Q, Wang S, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, Zhou X., Free PMC Article

    12/18/2021
    The long noncoding RNA of RMRP is downregulated by PERK, which induces apoptosis in hepatocellular carcinoma cells.

    The long noncoding RNA of RMRP is downregulated by PERK, which induces apoptosis in hepatocellular carcinoma cells.
    Yukimoto A, Watanabe T, Sunago K, Nakamura Y, Tanaka T, Koizumi Y, Yoshida O, Tokumoto Y, Hirooka M, Abe M, Hiasa Y., Free PMC Article

    11/6/2021
    Promoter Mutation Analysis of Long-Non-coding RNA RMRP Gene in Solid Tumors.

    Promoter Mutation Analysis of Long-Non-coding RNA RMRP Gene in Solid Tumors.
    Son HJ, Mo HY, Choi EJ, Yoo NJ, Lee SH.

    10/9/2021
    LncRNA RMRP knockdown promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-206/CDK9 axis.

    LncRNA RMRP knockdown promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-206/CDK9 axis.
    Lu JF, Qi LG, Zhu XB, Shen YX.

    09/18/2021
    Homozygous n.64C>T mutation in mitochondrial RNA-processing endoribonuclease gene causes cartilage hair hypoplasia syndrome in two siblings.

    Homozygous n.64C>T mutation in mitochondrial RNA-processing endoribonuclease gene causes cartilage hair hypoplasia syndrome in two siblings.
    Lugli L, Ciancia S, Bertucci E, Lucaccioni L, Calabrese O, Madeo S, Berardi A, Iughetti L.

    06/26/2021
    lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1.

    lncRNA RMRP knockdown suppress hepatocellular carcinoma biological activities via regulation miRNA-206/TACR1.
    Hongfeng Z, Andong J, Liwen S, Mingping B, Xiaowei Y, Mingyong L, Aimin Y.

    05/1/2021
    The expression analyses of RMRP, DDX5, and RORC in RRMS patients treated with different drugs versus naive patients and healthy controls.

    The expression analyses of RMRP, DDX5, and RORC in RRMS patients treated with different drugs versus naïve patients and healthy controls.
    Rahmani S, Noorolyai S, Ayromlou H, Khaze Shahgoli V, Shanehbandi D, Baghbani E, Abdoli Shadbad M, Jigari-Asl F, Khamiriyan M, Safaralizadeh R, Baradaran B.

    02/2/2021
    The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2.

    The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2.
    Vakkilainen S, Skoog T, Einarsdottir E, Middleton A, Pekkinen M, Öhman T, Katayama S, Krjutškov K, Kovanen PE, Varjosalo M, Lindqvist A, Kere J, Mäkitie O., Free PMC Article

    10/31/2020
    Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR-1-3p in non-small-cell lung cancer.

    Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR-1-3p in non-small-cell lung cancer.
    Wang Y, Luo X, Liu Y, Han G, Sun D.

    09/12/2020
    Inhibition of RMRP contributed to the improvement of oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced injury-induced neuronal injury, which might be mediated through the inhibition of autophagy and apoptosis pathways.

    Suppression of lncRNA RMRP ameliorates oxygen-glucose deprivation/re-oxygenation-induced neural cells injury by inhibiting autophagy and PI3K/Akt/mTOR-mediated apoptosis.
    Zhou Z, Xu H, Liu B, Dun L, Lu C, Cai Y, Wang H., Free PMC Article

    08/12/2020
    results found that lncRNA RMRP was closely related to the progression of bladder cancer.

    lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206.
    Cao HL, Liu ZJ, Huang PL, Yue YL, Xi JN.

    07/18/2020
    RMRP was highly expressed in neuroblastoma tissues. RMRP knockdown inhibited proliferation, migration and invasion in neuroblastoma cells. TACR1 was a target of miR-206 and RMRP performed as a molecular sponge of miR-206 to sequester miR-206 from TACR1 in neuroblastoma cells. TACR1 overexpression abrogated the inhibitory effect of RMRP downregulation on neuroblastoma cell progression by activating ERK1/2 pathway.

    LncRNA RMRP silence curbs neonatal neuroblastoma progression by regulating microRNA-206/tachykinin-1 receptor axis via inactivating extracellular signal-regulated kinases.
    Pan J, Zhang D, Zhang J, Qin P, Wang J., Free PMC Article

    07/11/2020
    MDWH is caused by RMRP mutations, and it can present with late-onset extraskeletal manifestations, like immunodeficiency and increased risk of malignancy.

    'Metaphyseal dysplasia without hypotrichosis' can present with late-onset extraskeletal manifestations.
    Vakkilainen S, Costantini A, Taskinen M, Wartiovaara-Kautto U, Mäkitie O., Free PMC Article

    06/13/2020
    elevated levels in T-cells of rheumatoid arthritis patients

    The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis.
    Moharamoghli M, Hassan-Zadeh V, Dolatshahi E, Alizadeh Z, Farazmand A.

    04/4/2020
    These results suggested that lncRNA-RMRP promoted the progression of intervertebral disc degeneration (IDD) through targeting miR-206, providing an attractive new therapeutic approach for the treatment of IDD disease.

    LncRNA-RMRP promotes nucleus pulposus cell proliferation through regulating miR-206 expression.
    Wang X, Peng L, Gong X, Zhang X, Sun R, Du J., Free PMC Article

    12/14/2019
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