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    RAN RAN, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5901, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children.

    Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children.
    Lin Q, Chen W, Tan J, Qian S, Su H, Zhao L, Yuan L, Ruan J, Huang X, Zhou H., Free PMC Article

    07/24/2024
    Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation.

    Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation.
    Gao W, Zhou J, Huang J, Zhang Z, Chen W, Zhang R, Kang T, Liao D, Zhong L.

    03/19/2024
    B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer.

    B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer.
    Garg R, Endzhievskaya S, Williamson M., Free PMC Article

    02/16/2024
    Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer.

    Development and validation of Ran as a prognostic marker in stage I and stage II primary breast cancer.
    El-Tanani M, Platt-Higgins A, Nsairat H, Matalka II, Ahmed KA, Zhang SD, Alshaer W, Awidi A, Matchett KB, Aljabali AA, Mishra V, Serrano-Aroca Á, Tambuwala MM, Rudland PS.

    08/16/2023
    Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.

    Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.
    Alquraan KM, Khabour OF.

    08/11/2023
    Matrix metalloproteinase 2 is a target of the RAN-GTP pathway and mediates migration, invasion and metastasis in human breast cancer.

    Matrix metalloproteinase 2 is a target of the RAN-GTP pathway and mediates migration, invasion and metastasis in human breast cancer.
    El-Tanani M, Platt-Higgins A, Lee YF, Al Khatib AO, Haggag Y, Sutherland M, Zhang SD, Aljabali AAA, Mishra V, Serrano-Aroca Á, Tambuwala MM, Rudland PS.

    11/19/2022
    Mechanistic convergence across initiation sites for RAN translation in fragile X associated tremor ataxia syndrome.

    Mechanistic convergence across initiation sites for RAN translation in fragile X associated tremor ataxia syndrome.
    Zhang Y, Glineburg MR, Basrur V, Conlon K, Wright SE, Krans A, Hall DA, Todd PK., Free PMC Article

    07/30/2022
    RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression.

    RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression.
    Liu X, Chen J, Long X, Lan J, Liu X, Zhou M, Zhang S, Zhou J., Free PMC Article

    03/26/2022
    NEAT1 Boosts the Development of Thoracic Aortic Aneurysm Through Targeting miR-324-5p/RAN.

    NEAT1 Boosts the Development of Thoracic Aortic Aneurysm Through Targeting miR-324-5p/RAN.
    Gao C, Sun J, Zhang Z, Xu Z.

    03/19/2022
    Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.

    Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.
    Elsheikh S, Kouzoukakis I, Fielden C, Li W, Lashin SE, Khair N, Raposo TP, Fadhil W, Rudland P, Aleskandarany M, Patel P, El-Tanani M, Ilyas M.

    01/22/2022
    RAN and YBX1 are required for cell proliferation and IL-4 expression and linked to poor prognosis in oral squamous cell carcinoma.

    RAN and YBX1 are required for cell proliferation and IL-4 expression and linked to poor prognosis in oral squamous cell carcinoma.
    Che X, Liu M, Li D, Li Z, Guo J, Jia R.

    11/13/2021
    Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.

    Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.
    Zhong Y, Cao L, Ma H, Wang Q, Wei P, Yang J, Mo Y, Cao L, Shuai C, Peng S., Free PMC Article

    11/13/2021
    Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.

    Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.
    Fawzy MS, Abu AlSel BT, Toraih EA., Free PMC Article

    10/23/2021
    More than a zip code: global modulation of cellular function by nuclear localization signals.

    More than a zip code: global modulation of cellular function by nuclear localization signals.
    Chang CC, Hsia KC.

    10/16/2021
    TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.

    TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
    Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogné B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Bellen HJ, Tan QK., Free PMC Article

    09/18/2021
    Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.

    Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.
    Tsuchiya K, Hayashi H, Nishina M, Okumura M, Sato Y, Kanemaki MT, Goshima G, Kiyomitsu T.

    09/4/2021
    Restoration of microRNA-197 expression suppresses oncogenicity in fibrosarcoma through negative regulation of RAN.

    Restoration of microRNA-197 expression suppresses oncogenicity in fibrosarcoma through negative regulation of RAN.
    Jain N, Das B, Mallick B.

    08/21/2021
    Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit.

    Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit.
    Huang S, Dougherty LL, Avasthi P., Free PMC Article

    08/7/2021
    Mixed-lineage leukemia protein modulates the loading of <i>let-7a</i> onto AGO1 by recruiting RAN.

    Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN.
    Zhu S, Chen Z, Jiang D, Wang R, Cheng X, Li D, Xv Q, Zhao F, Kim W, Guo G, Zhao C, Lou Z, Liu H., Free PMC Article

    06/12/2021
    Ran promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells.

    Ran promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells.
    Zhang C, Zhao X, Du W, Shen J, Li S, Li Z, Wang Z, Liu F.

    04/3/2021
    Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.

    Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
    Wang X, Li D, Sun L, Shen G, Liu H, Guo H, Ge M, Liang J, Chen P, Zhou J, Cao T, Wang Q, Gao X, Tong M, Hu S, Nie Y, Fan D, Wang X, Zhao X, Lu Y., Free PMC Article

    03/20/2021
    Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.

    Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
    Swart AL, Steiner B, Gomez-Valero L, Schütz S, Hannemann M, Janning P, Irminger M, Rothmeier E, Buchrieser C, Itzen A, Panse VG, Hilbi H., Free PMC Article

    03/13/2021
    RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.

    RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
    Jazurek-Ciesiolka M, Ciesiolka A, Komur AA, Urbanek-Trzeciak MO, Krzyzosiak WJ, Fiszer A.

    03/6/2021
    EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma.

    EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma.
    Dell'Anno I, Barbarino M, Barone E, Giordano A, Luzzi L, Bottaro M, Migliore L, Agostini S, Melani A, Melaiu O, Catalano C, Cipollini M, Silvestri R, Corrado A, Gemignani F, Landi S., Free PMC Article

    02/20/2021
    LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.

    LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
    Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C., Free PMC Article

    02/6/2021
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