| Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development. | Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development.
Kang ZR, Jiang S, Han JX, Gao Y, Xie Y, Chen J, Liu Q, Yu J, Zhao X, Hong J, Chen H, Chen YX, Chen H, Fang JY. | 01/5/2024 |
| BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions. | BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions.
Tian Y, Ma J, Wang H, Yi X, Wang H, Zhang H, Guo S, Yang Y, Zhang B, Du J, Shi Q, Gao T, Guo W, Li C., Free PMC Article | 11/1/2023 |
| Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance. | Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance.
González-Salazar LE, Granados-Portillo O, Medina-Vera I, Pichardo-Ontiveros E, Vigil-Martínez A, Guizar-Heredia R, Palacios-González B, Arteaga-Sánchez L, Hernández-Gómez KG, Avila-Nava A, Serralde-Zúñiga AE, Flores-López A, Noriega LG, Torres N, Olin-Sandoval V, Vázquez-Manjarrez N, Domínguez-Velázquez N, Reyes-García JG, Tovar AR, Guevara-Cruz M. | 12/24/2022 |
| Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. | Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells.
Wang K, Zhang Z, Tsai HI, Liu Y, Gao J, Wang M, Song L, Cao X, Xu Z, Chen H, Gong A, Wang D, Cheng F, Zhu H., Free PMC Article | 01/29/2022 |
| Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults. | Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults.
Vargas-Morales JM, Guizar-Heredia R, Méndez-García AL, Palacios-Gonzalez B, Schcolnik-Cabrera A, Granados O, López-Barradas AM, Vázquez-Manjarrez N, Medina-Vera I, Aguilar-López M, Tovar-Palacio C, Ordaz-Nava G, Rocha-Viggiano AK, Medina-Cerda E, Torres N, Ordovas JM, Tovar AR, Guevara-Cruz M, Noriega LG. | 11/27/2021 |
| Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. | Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth.
Lei MZ, Li XX, Zhang Y, Li JT, Zhang F, Wang YP, Yin M, Qu J, Lei QY., Free PMC Article | 10/9/2021 |
| The crystal structure of the oxidized form of the C318A variant of the human mitochondrial branched-chain aminotransferase was used to better understand the contributions of the individual cysteines and their oxidation states. | Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase.
Herbert D, Gibbs S, Riddick A, Conway M, Dong M., Free PMC Article | 06/13/2020 |
| BCAT2-mediated branched-chain amino acids catabolism is critical for the development of pancreatic ductal adenocarcinoma-harboring KRAS mutations. | BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY. | 04/18/2020 |
| Skeletal muscle amino acid transporter and BCAT2 expression prior to and following interval running or resistance exercise in mode-specific trained males. | Skeletal muscle amino acid transporter and BCAT2 expression prior to and following interval running or resistance exercise in mode-specific trained males.
Roberson PA, Haun CT, Mobley CB, Romero MA, Mumford PW, Martin JS, Roberts MD. | 02/2/2019 |
| Data suggest that both oncogenic mutations and cancer tissue-of-origin influence BCAA (branched-chain amino acid) metabolism in neoplastic tissue and neoplastic expression of cytosolic BCAT1 and mitochondrial BCAT2. (BCAT = branched-chain-amino-acid transaminase) [REVIEW] | Branched-chain amino acid metabolism in cancer.
Ananieva EA, Wilkinson AC., Free PMC Article | 07/21/2018 |
| The mitochondrial isoform human brain BCAT 2 is largely confined to vascular endothelial cells, whereas the cytosolic human brain BCAT 1 is restricted to neurons. | Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.
Hull J, Hindy ME, Kehoe PG, Chalmers K, Love S, Conway ME. | 02/16/2013 |
| BCATc (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (mitochondrial). Furthermore, the CXXC motif of BCATc was estimated to be 80 mV lower, suggesting that BCATm is more oxidizing in nature. | Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase.
Coles SJ, Hancock JT, Conway ME. | 05/19/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| The effect of nitric oxide modification on the functionality of human mitochondrial and cytosolic branched-chain aminotransferases (hBCATm and hBCATc, respectively) was investigated. | S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation.
Coles SJ, Easton P, Sharrod H, Hutson SM, Hancock J, Patel VB, Conway ME. | 01/21/2010 |
| identification of a peroxide-sensitive redox switch at the CXXC motif | Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.
Conway ME, Yennawar N, Wallin R, Poole LB, Hutson SM. | 01/21/2010 |
| ption of the CXXC center results in altered substrate orientation and deprotonation of the amino group of pyridoxamine 5'-phosphate, which inhibits catalysis | Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis.
Yennawar NH, Islam MM, Conway M, Wallin R, Hutson SM. | 01/21/2010 |
| Studies of ketimine and pyridoxamine phosphate forms of BCAT@ reaction intermediates reveal substrate specificity for L-branched chain amino acids via a group of hydrophobic residues that form three hydrophobic surfaces and lock the side chain in place. | Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms.
Yennawar NH, Conway ME, Yennawar HP, Farber GK, Hutson SM. | 01/21/2010 |
| role of cysteine residues in the regulatory CXXC motif | Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.
Conway ME, Poole LB, Hutson SM. | 01/21/2010 |