| Dominant alleles of RAD51, TP53 and XRCC1 combined genotypes indicated a strong protective role against hereditary breast cancer. | Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women.
Krivokuca AM, Cavic MR, Malisic EJ, Rakobradovic JD, Kolarevic-Ivankovic D, Tomasevic ZI, Brankovic-Magic MV. | 04/8/2017 |
| Intramolecular binding of the rad9 C-terminus in the checkpoint clamp Rad9-Hus1-Rad1 is closely linked with its DNA binding. | Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding.
Takeishi Y, Iwaya-Omi R, Ohashi E, Tsurimoto T., Free PMC Article | 11/7/2015 |
| Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies. | Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Querol-Audí J, Yan C, Xu X, Tsutakawa SE, Tsai MS, Tainer JA, Cooper PK, Nogales E, Ivanov I., Free PMC Article | 08/25/2012 |
| The RAD1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins. | 9-1-1: PCNA's specialized cousin.
Eichinger CS, Jentsch S. | 04/7/2012 |
| CK2 plays a crucial role in the ATR-dependent checkpoint pathway through its ability to phosphorylate Ser-341 and Ser-387 of the Rad9 subunit of the Rad9-Hus1-Rad1 complex | Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.
Takeishi Y, Ohashi E, Ogawa K, Masai H, Obuse C, Tsurimoto T. | 11/27/2010 |
| 9-1-1 complex is a component of the mismatch repair involved in MNNG-induced damage response. | Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1.
Bai H, Madabushi A, Guan X, Lu AL., Free PMC Article | 08/2/2010 |
| Rad9-Rad1-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase. | Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9-Rad1-Hus1 complex.
Park MJ, Park JH, Hahm SH, Ko SI, Lee YR, Chung JH, Sohn SY, Cho Y, Kang LW, Han YS. | 01/25/2010 |
| The DNA binding domain (DBD) within the hLigI catalytic fragment interacts with both PCNA and the heterotrimeric cell-cycle checkpoint clamp, hRad9-hRad1-hHus1 (9-1-1). | The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.
Song W, Pascal JM, Ellenberger T, Tomkinson AE., Free PMC Article | 01/21/2010 |
| The interdomain connecting loops (IDC loop) of hRad9, hHus1, and hRad1 are largely divergent and unique structural features of the 9-1-1 complex that are proposed to contribute to DNA damage recognition. | Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex.
Xu M, Bai L, Gong Y, Xie W, Hang H, Jiang T., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAn approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. | 11/5/2008 |
| Human thymine DNA glycosylase activity is significantly stimulated by hHus1, hRad1, hRad9 separately, and by the 9-1-1 complex. | The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL., Free PMC Article | 01/21/2010 |
| Jab1 physically associates with the 9-1-1 complex; this association is mediated through direct interaction between Jab1 and Rad1, one of the subunits of the 9-1-1 complex | Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex.
Huang J, Yuan H, Lu C, Liu X, Cao X, Wan M., Free PMC Article | 01/21/2010 |
| we report successful tri-cistronic cloning, overexpression and purification of a three-protein complex of Rad9, Rad1 and Hus1 using a single hexa-histidine tag. | Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex.
Singh VK, Nurmohamed S, Davey SK, Jia Z. | 01/21/2010 |
| The long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA. | The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.
Smirnova E, Toueille M, Markkanen E, Hübscher U., Free PMC Article | 01/21/2010 |
| Human NEIL1 DNA glycosylase activity is significantly stimulated by hRad1 and by the Rad9/Rad1/Hus1 heterotrimer. | The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase.
Guan X, Bai H, Shi G, Theriot CA, Hazra TK, Mitra S, Lu AL., Free PMC Article | 01/21/2010 |
| The human Rad9/Rad1/Hus1 complex interacts with and stimulates DNA polymerase beta activity. | The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.
Toueille M, El-Andaloussi N, Frouin I, Freire R, Funk D, Shevelev I, Friedrich-Heineken E, Villani G, Hottiger MO, Hübscher U., Free PMC Article | 01/21/2010 |
| PCNA and the Rad9/Rad1/Hus1 complex can independently bind and activate Fen1; acetylation of Fen1 by p300-HAT abolished the stimulatory effect of the complex but not that of PCNA, suggesting a possible mechanism of regulation of this repair pathway | The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.
Friedrich-Heineken E, Toueille M, Tännler B, Bürki C, Ferrari E, Hottiger MO, Hübscher U. | 01/21/2010 |
| RAD1 is a potential intrinsic chaperone in the stabilization of HUS1 for the heterotrimeric (RAD9-RAD1-HUS1) checkpoint complex formation. | Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation.
Hirai I, Sasaki T, Wang HG. | 01/21/2010 |
| complex with rad9 and hus1 is a damage-specific activator of flap endonuclease 1 | The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.
Wang W, Brandt P, Rossi ML, Lindsey-Boltz L, Podust V, Fanning E, Sancar A, Bambara RA., Free PMC Article | 01/21/2010 |
| These data provide in vivo evidence that the human 9-1-1 complex participates in DNA repair in addition to its previously described role in DNA damage sensing. | The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.
Brandt PD, Helt CE, Keng PC, Bambara RA. | 01/21/2010 |
| Rad9, Hus1, and Rad1 heterotrimeric complex chromatin binding is a proximal event in the checkpoint signaling cascade | Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Roos-Mattjus P, Vroman BT, Burtelow MA, Rauen M, Eapen AK, Karnitz LM. | 01/21/2010 |
| human DNA ligase I is stimulated by the Rad9-rad1-Hus1 checkpoint complex | Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.
Wang W, Lindsey-Boltz LA, Sancar A, Bambara RA. | 01/21/2010 |