| Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury. | Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury.
Qiu X, Guo Y, Liu MF, Zhang B, Li J, Wei JF, Li M., Free PMC Article | 11/28/2023 |
| Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression. | Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression.
Ma Y, Liu Y, Meng H., Free PMC Article | 11/18/2023 |
| Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs. | Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs.
Said EA, Al-Dughaishi S, Al-Hatmi W, Al-Reesi I, Al-Balushi MS, Al-Bimani A, Al-Busaidi JZ, Al-Riyami M, Al-Khabori M, Al-Kindi S, Procopio FA, Al-Sinawi S, Al-Ansari A, Koh CY, Al-Naamani K, Al-Jabri AA., Free PMC Article | 10/30/2023 |
| Pleiotrophin drives a prometastatic immune niche in breast cancer. | Pleiotrophin drives a prometastatic immune niche in breast cancer.
Ganguly D, Schmidt MO, Coleman M, Ngo TC, Sorrelle N, Dominguez ATA, Murimwa GZ, Toombs JE, Lewis C, Fang YV, Valdes-Mora F, Gallego-Ortega D, Wellstein A, Brekken RA., Free PMC Article | 02/28/2023 |
| Pleiotrophin attenuates the senescence of dental pulp stem cells. | Pleiotrophin attenuates the senescence of dental pulp stem cells.
Zhang L, Xia D, Wang C, Gao F, Hu L, Li J, Jin L. | 12/24/2022 |
| LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant progression and stemness in lung squamous cell carcinoma. | LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant progression and stemness in lung squamous cell carcinoma.
Peng BH, Ji YF, Qiu XJ., Free PMC Article | 07/23/2022 |
| Pleiotrophin Serum Level is Increased in Relapsing-Remitting Multiple Sclerosis and Correlates With Sex, BMI and Treatment. | Pleiotrophin Serum Level is Increased in Relapsing-Remitting Multiple Sclerosis and Correlates With Sex, BMI and Treatment.
Reyes-Mata PM, Rojas-Mayorquín AE, Carrera-Quintanar L, González-Castillo C, Mireles-Ramírez MA, Guerrero-García JJ, Ortuño-Sahagún D. | 03/19/2022 |
| Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on alphanubeta3 integrin expression. | Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on α(ν)β(3) integrin expression.
Lamprou M, Kastana P, Kofina F, Tzoupis Η, Barmpoutsi S, Sajib MS, Koutsioumpa M, Poimenidi E, Zompra AA, Tassopoulos D, Choleva E, Tselios T, Mikelis CM, Papadimitriou E. | 10/2/2021 |
| Discovery of PTN as a serum-based biomarker of pro-metastatic prostate cancer. | Discovery of PTN as a serum-based biomarker of pro-metastatic prostate cancer.
Liu S, Shen M, Hsu EC, Zhang CA, Garcia-Marques F, Nolley R, Koul K, Rice MA, Aslan M, Pitteri SJ, Massie C, George A, Brooks JD, Gnanapragasam VJ, Stoyanova T., Free PMC Article | 10/2/2021 |
| Pleiotrophin interacts with glycosaminoglycans in a highly flexible and adaptable manner. | Pleiotrophin interacts with glycosaminoglycans in a highly flexible and adaptable manner.
Ryan E, Shen D, Wang X., Free PMC Article | 07/24/2021 |
| Structural Characterization of the Interaction between the alphaMI-Domain of the Integrin Mac-1 (alphaMbeta2) and the Cytokine Pleiotrophin. | Structural Characterization of the Interaction between the α(M)I-Domain of the Integrin Mac-1 (α(M)β(2)) and the Cytokine Pleiotrophin.
Feng W, Nguyen H, Shen D, Deng H, Jiang Z, Podolnikova N, Ugarova T, Wang X., Free PMC Article | 05/15/2021 |
| Association of Midkine and Pleiotrophin Gene Polymorphisms With Systemic Lupus Erythematosus Susceptibility in Chinese Han Population. | Association of Midkine and Pleiotrophin Gene Polymorphisms With Systemic Lupus Erythematosus Susceptibility in Chinese Han Population.
Wang P, Mao YM, Zhao CN, Wang JB, Li XM, Ye DQ, Pan HF., Free PMC Article | 05/15/2021 |
| Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis. | Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis.
Zhang X, Wang S, Lin G, Wang D. | 05/15/2021 |
| Long noncoding RNA OIP5-AS1 mediates resistance to doxorubicin by regulating miR-137-3p/PTN axis in osteosarcoma. | Long noncoding RNA OIP5-AS1 mediates resistance to doxorubicin by regulating miR-137-3p/PTN axis in osteosarcoma.
Sun X, Tian C, Zhang H, Han K, Zhou M, Gan Z, Zhu H, Min D. | 03/6/2021 |
| RNA binding protein GNL3 up-regulates IL24 and PTN to promote the development of osteoarthritis. | RNA binding protein GNL3 up-regulates IL24 and PTN to promote the development of osteoarthritis.
Zhu Z, Xie J, Manandhar U, Yao X, Bian Y, Zhang B. | 02/27/2021 |
| Pleiotrophin: Activity and mechanism. | Pleiotrophin: Activity and mechanism.
Wang X., Free PMC Article | 02/2/2021 |
| Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population. | Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population.
Lv Y, Sun Y, Dai D, Luan ZL, Lu HY, Li CJ, Luo YY. | 12/19/2020 |
| Mechanistically, PTN promoted chronic myelogenous leukemia stem cell survival and TKI resistance via induction of Jun and the unfolded protein response. | Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.
Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP., Free PMC Article | 07/25/2020 |
| PTN levels in the serum could be a new effective biomarker for the diagnosis and prognosis of SCLC. | Serum pleiotrophin as a diagnostic and prognostic marker for small cell lung cancer.
Xu C, Wang Y, Yuan Q, Wang W, Chi C, Zhang Q, Zhang X., Free PMC Article | 06/27/2020 |
| Pleiotrophin can be considered as an interesting molecule to promote re-endothelialisation. | Pleiotrophin: Analysis of the endothelialisation potential.
Copes F, Ramella M, Fusaro L, Mantovani D, Cannas M, Boccafoschi F. | 11/23/2019 |
| The data reveal that CDK5 is activated by PTN, in an RPTPbeta-zeta-dependent manner, regulates PTN-induced cell migration and is an attractive target for the inhibition of PTN pro-angiogenic properties. | Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.
Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Lamprou M, Skoura A, Megalooikonomou V, Papadimitriou E., Free PMC Article | 10/5/2019 |
| esults point to a possible important role of PTN in RA and OA. We firstly report a serological pattern of PTN in the sera and synovial fluids of RA patients. | Pleiotrophin, the angiogenic and mitogenic growth factor: levels in serum and synovial fluid in rheumatoid arthritis and osteoarthritis : And correlation with clinical, laboratory and radiological indices.
Fadda SMH, Bassyouni IH, Khalifa RH, Elsaid NY. | 09/14/2019 |
| the mechanism of chemoresistance by chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis depended on the NF-kappaB pathway | Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.
Huang P, Ouyang DJ, Chang S, Li MY, Li L, Li QY, Zeng R, Zou QY, Su J, Zhao P, Pei L, Yi WJ., Free PMC Article | 05/18/2019 |
| The high expression of PTN is significantly relevant to the advanced TNM stage and poor OS in tumor patients. PTN can serve as a promising biomarker to predict unfavorable survival outcomes, and it may be a potential target for tumor treatment. | A meta-analysis on the role of pleiotrophin (PTN) as a prognostic factor in cancer.
Zhou J, Yang Y, Zhang Y, Liu H, Dou Q., Free PMC Article | 04/20/2019 |
| There was a relationship between the expression levels of both proteins and survival time. CREB3L1 and PTN expression levels serve as biomarkers with utility in grading gliomas. Absence of CREB3L1 and presence of PTN in brain glioma cells correlate with survival time of the glioma patients. | CREB3L1 and PTN expressions correlate with prognosis of brain glioma patients.
Liu LQ, Feng LF, Nan CR, Zhao ZM., Free PMC Article | 03/9/2019 |