| Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen. | Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen.
Salama MA, Anwar Ismail A, Islam MS, K G AR, Al Kawas S, Samsudin AR, A C SA., Free PMC Article | 07/16/2024 |
| Prostaglandin E2 EP receptors in cardiovascular disease: An update. | Prostaglandin E2 EP receptors in cardiovascular disease: An update.
Bryson TD, Harding P. | 01/22/2022 |
| No significant differences in EP1 intensity were detected for histological, stage, grading, metastatic and recurrent subtypes in endometrial cancer. | Prostaglandin E2 receptor EP1 in healthy and diseased human endometrium.
Zhu J, Mayr D, Kuhn C, Mahner S, Jeschke U, von Schönfeldt V. | 05/19/2018 |
| COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival | Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival.
Yang HJ, Jiang JH, Yang YT, Yang XD, Guo Z, Qi YP, Zeng FH, Zhang KL, Chen NZ, Xiang BD, Li LQ., Free PMC Article | 07/1/2017 |
| Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema | Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
Plaza-Serón Mdel C, Ayuso P, Pérez-Sánchez N, Doña I, Blanca-Lopez N, Flores C, Galindo L, Molina A, Perkins JR, Cornejo-García JA, Agúndez JA, García-Martín E, Campo P, Canto G, Blanca M. | 03/18/2017 |
| suppression of EP1 prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels | Retinoic acid morpholine amide (RAMA) inhibits expression of Fas ligand through EP1 receptor in colon cancer cells.
Chen SX, Du SY, Wang YT, Zhao HC, Zhang YL, Yao L. | 02/18/2017 |
| A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1. | Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2.
Sood R, Flint-Ashtamker G, Borenstein D, Barki-Harrington L., Free PMC Article | 04/2/2016 |
| NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Immunohistochemistry showed p65, FoxC2, EP1 receptor and beta1-integrin were all highly expressed in the HCC cases | Prostaglandin E2 stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway.
Bai X, Wang J, Guo Y, Pan J, Yang Q, Zhang M, Li H, Zhang L, Ma J, Shi F, Shu W, Wang Y, Leng J., Free PMC Article | 11/7/2015 |
| COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation. | Prostaglandin receptor EP₁-mediated differential degradation of cyclooxygenases involves a specific lysine residue.
Spector-Chotiner A, Shraga-Heled N, Sood R, Rimon G, Barki-Harrington L. | 03/15/2014 |
| through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7. | Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S. | 11/30/2013 |
| PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells. | Prostaglandin E2 receptor EP1 phosphorylate CREB and mediates MMP2 expression in human cholangiocarcinoma cells.
Sun B, Rong R, Jiang H, Zhang H, Wang Y, Bai X, Zhang M, Ma J, Xia S, Shu W, Zhang L, Leng J. | 11/16/2013 |
| Our study suggests that the PGE EP1 receptor regulates FAK phosphorylation by activating the PKC/c-Src and EGFR signal pathways, which may coordinately regulate adhesion and migration in HCC | Prostaglandin E₂ receptor EP1-mediated phosphorylation of focal adhesion kinase enhances cell adhesion and migration in hepatocellular carcinoma cells.
Bai X, Wang J, Zhang L, Ma J, Zhang H, Xia S, Zhang M, Ma X, Guo Y, Rong R, Cheng S, Shu W, Wang Y, Leng J. | 11/2/2013 |
| PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction | NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4).
Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Kracht M, Püschel GP., Free PMC Article | 07/6/2013 |
| Suggest that the anti-carcinogenic effects of EGCG in hepatocellular carcinoma might be mediated, at least partially, through the suppressing EP(1) receptor expression and PGE(2) production. | Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro.
Jin J, Chang Y, Wei W, He YF, Hu SS, Wang D, Wu YJ., Free PMC Article | 09/1/2012 |
| new role for the EP(1) receptor in resolving inflammation through down-regulation of COX-2. | Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation.
Haddad A, Flint-Ashtamker G, Minzel W, Sood R, Rimon G, Barki-Harrington L., Free PMC Article | 07/28/2012 |
| Neuroblastoma express all four forms of PGE(2) receptors. | Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
Rasmuson A, Kock A, Fuskevåg OM, Kruspig B, Simón-Santamaría J, Gogvadze V, Johnsen JI, Kogner P, Sveinbjörnsson B., Free PMC Article | 06/9/2012 |
| A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation. | Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
Singh P, Hoggatt J, Hu P, Speth JM, Fukuda S, Breyer RM, Pelus LM., Free PMC Article | 05/5/2012 |
| The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility. | The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.
Arulkumaran S, Kandola MK, Hoffman B, Hanyaloglu AC, Johnson MR, Bennett PR. | 04/14/2012 |
| Data indicate that not only Cox-2 but also EP1 and EP3 could be important targets for chemosensitization and inhibition of metastasis in breast cancers that are resistant to chemotherapy. | Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells.
Kang JH, Song KH, Jeong KC, Kim S, Choi C, Lee CH, Oh SH., Free PMC Article | 02/11/2012 |
| EP1 functions as a suppressor of tumor metastasis; loss of nuclear EP1 is associated with poorer overall survival and may contribute to disparities in outcome in different populations. | Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities.
Ma X, Kundu N, Ioffe OB, Goloubeva O, Konger R, Baquet C, Gimotty P, Reader J, Fulton AM., Free PMC Article | 09/17/2011 |
| We could not find an association of EP1 gene with suicide in the Japanese population | Association study of EP1 gene polymorphisms with suicide completers in the Japanese population.
Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y, Hishimoto A. | 09/17/2011 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
Grilo A, Sáez-Rosas MP, Santos-Morano J, Sánchez E, Moreno-Rey C, Real LM, Ramírez-Lorca R, Sáez ME. | 12/5/2010 |
| the PGE(2) and EP1 interaction enhanced migration of oral cancer cells through an increase in ICAM-1 production | Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells.
Yang SF, Chen MK, Hsieh YS, Chung TT, Hsieh YH, Lin CW, Su JL, Tsai MH, Tang CH., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway. | Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells.
Liu JF, Fong YC, Chang CS, Huang CY, Chen HT, Yang WH, Hsu CJ, Jeng LB, Chen CY, Tang CH., Free PMC Article | 05/31/2010 |