| Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors. | Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.
Joshi P, Ayyagari V, Kandel S, Modur V, Iqbal MF, Robinson K, Gao J, Rao K., Free PMC Article | 06/5/2024 |
| Expression of Rab25 is down-regulated in the foreskin of children with hypospadias. | Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Zhang Q, Zhang Z, He X, Liu Z, Shen L, Long C, Wei G, Liu X. | 11/3/2023 |
| Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25. | Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.
Hu CH, Yang XJ, Yu L, Wang LY, Zhao XC, Han CH. | 05/8/2021 |
| Loss of Rab25 promotes the development and neoplastic transition of skin squamous cell carcinoma through dysregulation of integrin trafficking. | Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.
Jeong H, Lim KM, Kim KH, Cho Y, Lee B, Knowles BC, Roland JT, Zwerner JP, Goldenring JR, Nam KT., Free PMC Article | 04/18/2020 |
| Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma | Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma.
Gu Y, Zou YM, Lei D, Huang Y, Li W, Mo Z, Hu Y., Free PMC Article | 07/6/2019 |
| Rab25 overexpression induced erlotinib resistance, whereas Rab25 knockdown reversed this refractoriness in vitro and in vivo. Moreover, Rab25 interacts with beta1 integrin and promotes its trafficking to the cytoplasmic membrane. | Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β-catenin pathway in NSCLC.
Wang J, Zhou P, Wang X, Yu Y, Zhu G, Zheng L, Xu Z, Li F, You Q, Yang Q, Zhuo W, Sun J, Chen Z., Free PMC Article | 06/23/2019 |
| Rab25 modulates cancer cell invasion through coordinated regulation of beta1-integrin to activation of EGFR and expression of VEGF-A to increase the level of Snail protein and subsequent Fascin expression. | Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY., Free PMC Article | 01/26/2019 |
| ZEB2 directly binds to E-box sequences in the RAB25 promoter.ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 during epithelial-to-mesenchymal transition. | ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.
Skrypek N, Bruneel K, Vandewalle C, De Smedt E, Soen B, Loret N, Taminau J, Goossens S, Vandamme N, Berx G., Free PMC Article | 12/29/2018 |
| Results indicated that miR-577 suppressed EMT by inhibiting Rab25 expression in breast cancer (BC). MiR-577 and Rab25 are considered potential targets of BC treatment. | MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25.
Yin C, Mou Q, Pan X, Zhang G, Li H, Sun Y., Free PMC Article | 12/22/2018 |
| Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions | Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB., Free PMC Article | 01/20/2018 |
| Our results suggest that Rab25 tumourigenic potential and chemoresistance relies on HIF1 activity in aggressive and metastatic ovarian cancer | Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.
Gomez-Roman N, Sahasrabudhe NM, McGregor F, Chalmers AJ, Cassidy J, Plumb J., Free PMC Article | 12/16/2017 |
| The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line. | Rab11 family expression in the human placenta: Localization at the maternal-fetal interface.
Taglauer ES, Artemiuk PA, Hanscom SR, Lindsay AJ, Wuebbolt D, Breathnach FM, Tully EC, Khan AR, McCaffrey MW., Free PMC Article | 10/14/2017 |
| Data show that Rab25 is responsible for RIN1-induced EGFR signaling and tumor malignancy in clear cell renal cell carcinoma cell. | RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25.
Feng ZH, Fang Y, Zhao LY, Lu J, Wang YQ, Chen ZH, Huang Y, Wei JH, Liang YP, Cen JJ, Pan YH, Liao B, Chen W, Luo JH., Free PMC Article | 09/30/2017 |
| Promoter methylation results in downregulation of RAB25 expression in oropharyngeal squamous cell carcinoma. Decreased Rsb25 expression is associated with lymph node metastasis. | RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.
Clausen MJ, Melchers LJ, Mastik MF, Slagter-Menkema L, Groen HJ, Laan BF, van Criekinge W, de Meyer T, Denil S, van der Vegt B, Wisman GB, Roodenburg JL, Schuuring E., Free PMC Article | 06/3/2017 |
| Rab25 may act as a tumor promoter. | Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells.
Ding B, Cui B, Gao M, Li Z, Xu C, Fan S, He W., Free PMC Article | 03/25/2017 |
| Rab25 was upregulated in hepatocellular carcinoma tissues and cells compared with normal liver tissues and cell lines. Rab25 overexpression correlated with advanced tumor stage and nodal metastasis.Rab25 depletion blocked cell growth rate, inhibited colony formation, downregulated AKT phosphorylation, inhibited the Wnt signaling pathway and its target genes, and negatively regulated the invading ability of HCC cells. | Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion.
Geng D, Zhao W, Feng Y, Liu J. | 02/4/2017 |
| Data show that both rab G-Protein RAB25 and RNA-binding protein ESRP1 were suppressed by transcription factor ZEB1, which was in turn regulated via epigenetic mechanisms. | Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Kikuchi M, Yamashita K, Waraya M, Minatani N, Ushiku H, Kojo K, Ema A, Kosaka Y, Katoh H, Sengoku N, Enomoto T, Tanino H, Sawanobori M, Watanabe M., Free PMC Article | 12/17/2016 |
| Rab25 expression is a potential prognostic index for advanced NSCLC patients and its inhibition may improve chemosensitization in NSCLC treatment. | Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer.
Ma YF, Yang B, Li J, Zhang T, Guo JT, Chen L, Li M, Chu J, Liang CY, Liu Y. | 04/16/2016 |
| These results showed that high levels of Rab25 expression were significantly correlated with renal cell carcinoma invasion classification (P < 0.01), lymph-node metastasis (P < 0.001), and pathological stage (P < 0.01). | Rab25 upregulation correlates with the proliferation, migration, and invasion of renal cell carcinoma.
Li Y, Jia Q, Zhang Q, Wan Y. | 05/30/2015 |
| High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma. | High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.
Téllez-Gabriel M, Arroyo-Solera I, León X, Gallardo A, López M, Céspedes MV, Casanova I, López-Pousa A, Quer M, Mangues MA, Barnadas A, Mangues R, Pavón MA., Free PMC Article | 09/6/2014 |
| the crystal structure of Rab25 in complex with the C-terminal region of FIP2, which consists of a central dimeric FIP2 coiled-coil that mediates a heterotetrameric Rab25-(FIP2)2-Rab25 complex. | Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase.
Lall P, Horgan CP, Oda S, Franklin E, Sultana A, Hanscom SR, McCaffrey MW, Khan AR. | 02/22/2014 |
| Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3beta/Snail signaling. | Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling.
Zhang J, Wei J, Lu J, Tong Z, Liao B, Yu B, Zheng F, Huang X, Chen Z, Fang Y, Li B, Chen W, Xie D, Luo J. | 12/14/2013 |
| These findings suggest that Rab25 plays an important role in tumor migration and metastasis, and that understanding its function may lead to the development of new strategies to prevent metastasis in oral cancer patients. | Rab25 regulates invasion and metastasis in head and neck cancer.
Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, Molinolo A, Gutkind JS, Weigert R., Free PMC Article | 09/28/2013 |
| Rab25 controls intestinal cell polarity through the regulation of gene expression | Rab25 regulates integrin expression in polarized colonic epithelial cells.
Krishnan M, Lapierre LA, Knowles BC, Goldenring JR., Free PMC Article | 09/14/2013 |
| RAB25 has been implicated in various cancers, with reports presenting it as both an oncogene and a tumour-suppressor gene. [Review] | Rab25 in cancer: a brief update.
Mitra S, Cheng KW, Mills GB., Free PMC Article | 05/11/2013 |