| CRTAM promotes antitumor immune response in triple negative breast cancer by enhancing CD8+ T cell infiltration. | CRTAM promotes antitumor immune response in triple negative breast cancer by enhancing CD8+ T cell infiltration.
Zheng S, Yang B, Li L, Chen M, Zhang L, Chi W, Shao ZM, Xiu B, Chi Y, Wu J. | 02/27/2024 |
| Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to Characterize a Monoclonal Antibody. | Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to Characterize a Monoclonal Antibody.
Barragan-Galvez JC, Gonzalez-Orozco M, Hernandez-Flores A, Maravillas-Montero JL, Chavez-Guerrero Y, Ortiz-Navarrete V. | 01/16/2021 |
| The findings suggest, for the first time, that the tumor microenvironment in acute lymphoblastic leukemia directly contribute to exhaustion of NK cell functions by the CRTAM/Necl-2 interaction, and that the potential regulatory role of exhausted-like NK cells may favor malignant progression at the expense of anti-tumor responses. | CRTAM(+) NK cells endowed with suppressor properties arise in leukemic bone marrow.
Ramírez-Ramírez D, Padilla-Castañeda S, Galán-Enríquez CS, Vadillo E, Prieto-Chávez JL, Jiménez-Hernández E, Vilchis-Ordóñez A, Sandoval A, Balandrán JC, Pérez-Tapia SM, Ortiz-Navarrete V, Pelayo R. | 05/9/2020 |
| These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene. | CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
Takeuchi A, Badr Mel S, Miyauchi K, Ishihara C, Onishi R, Guo Z, Sasaki Y, Ike H, Takumi A, Tsuji NM, Murakami Y, Katakai T, Kubo M, Saito T., Free PMC Article | 05/14/2016 |
| CRTAM is negatively regulated by ZEB1 in T cells. | CRTAM is negatively regulated by ZEB1 in T cells.
Rojas-Marquez C, Valle-Rios R, Lopez-Bayghen E, Ortiz-Navarrete V. | 08/15/2015 |
| Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. | A genome-wide association study for malignant mesothelioma risk.
Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ. | 04/19/2014 |
| The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. | Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2.
Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF. | 02/22/2014 |
| The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 on tumor cells. | CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells.
Dessarthe B, Thedrez A, Latouche JB, Cabillic F, Drouet A, Daniel P, de La Pintière CT, Catros V, Toutirais O. | 08/3/2013 |
| Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. | Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.
Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, Celedón JC, Avila L, Soto-Quiros ME, Weiss ST., Free PMC Article | 04/14/2012 |
| Results show that CRTAM is a molecule involved in epithelial cell adhesion. | CRTAM: A molecule involved in epithelial cell adhesion.
Garay E, Patiño-López G, Islas S, Alarcón L, Canche-Pool E, Valle-Rios R, Medina-Contreras O, Granados G, Chávez-Munguía B, Juaristi E, Ortiz-Navarrete V, González-Mariscal L. | 02/26/2011 |
| CRTAM expression is driven by the JNK-AP-1 signaling pathway. | Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes.
Valle-Rios R, Patiño-Lopez G, Medina-Contreras O, Canche-Pool E, Recillas-Targa F, Lopez-Bayghen E, Zlotnik A, Ortiz-Navarrete V. | 01/21/2010 |
| NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 | The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.
Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. | 01/21/2010 |
| Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system | Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.
Galibert L, Diemer GS, Liu Z, Johnson RS, Smith JL, Walzer T, Comeau MR, Rauch CT, Wolfson MF, Sorensen RA, Van der Vuurst de Vries AR, Branstetter DG, Koelling RM, Scholler J, Fanslow WC, Baum PR, Derry JM, Yan W. | 01/21/2010 |